US4356173A
Expired / Lapsed
US
⏱️ 0.0 years remaining
IgM Derivatives and process for the preparation thereof
Assignee: Teijin Ltd
•
Filing: 1981-04-17
•
Granted: 1982-10-26
•
Expires: 2001-04-17
Abstract
Abstract IgM derivatives into which acyl groups expressed by the following formula (I) are introduced to make their anticomplement activity weak by acylating the free amino groups existing in IgM up to 1-90% (acylation percentage) --COR (I) where R indicates an alkyl group having 1 to 4 carbon atoms, or a carboxylated alkyl group expressed by --(CH 2 )mCOOH (m is 2 or 3) or --CH═CHCOOH. These IgM derivatives can be used for making immunoglobulin preparations for intravenous injection use.
Inventors
- 👤 Shuzi Miura
- 👤 Tsunemasa Yoshida
- 👤 Shoji Ono
- 👤 Yasuhiko Masuho
- 👤 Shuzo Sawada
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 20:28
CPC Classifications
C; C07; C07K; C07K16/00; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S424/00; Y10S424/806; Y10S530/00; Y10S530/863
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
65 words
IgM derivatives into which acyl groups expressed by the following formula (I) are introduced to make their anticomplement activity weak by acylating the free amino groups existing in IgM up to 1-30% (acylation percentage) --COR (I) where R indicates an alkyl group having 1 to 4 carbon atoms, or a carboxylated alkyl group expressed by --(CH 2 )mCOOH (m is 2 or 3) or --CH═CHCOOH.
Claim 2
Dependent Claim
65 words
IgM derivatives into which acyl groups expressed by the following formula (I) are introduced to make their anticomplement activity weak by acylating the free amino groups existing in IgM up to 1-30% (acylation percentage) --COR (I) where R indicates an alkyl group having 1 to 4 carbon atoms, or a carboxylated alkyl group expressed by --(CH 2 )mCOOH (m is 2 or 3) or --CH═CHCOOH.
Claim 3
Dependent Claim
21 words
IgM derivatives according to claim 1, wherein the anticomplement value of a solution of 1% IgM derivative is 50% or less.
Claim 4
Dependent Claim
96 words
A process for the preparation of I g M derivatives whose anticomplement activity is weakened comprising acylating 1 to 30% (acylation percentage) of the free amino groups existing in I g M with an acylating agent in an amount of 0.5 to 20% based on the weight of the I g M which contains acyl groups expressed by the following formula (I) in their molecules --COR (I) where R indicates an alkyl group having 1 to 4 carbon atoms, or a carboxylated alkyl group expressed by --(CH 2 )mCOOH (m is 2 or 3) or --CH═CHCOOH.
Claim 5
Dependent Claim
96 words
A process for the preparation of I g M derivatives whose anticomplement activity is weakened comprising acylating 1 to 30% (acylation percentage) of the free amino groups existing in I g M with an acylating agent in an amount of 0.5 to 20% based on the weight of the I g M which contains acyl groups expressed by the following formula (I) in their molecules --COR (I) where R indicates an alkyl group having 1 to 4 carbon atoms, or a carboxylated alkyl group expressed by --(CH 2 )mCOOH (m is 2 or 3) or --CH═CHCOOH.
Claim 6
Dependent Claim
99 words
An immunoglobulin preparation for intravenous injection use which contains 20% by weight or more of I g M derivatives into which acyl groups expressed by the following formula (I) are introduced to make their anticomplement activity weak by acylating the free amino groups existing in I g M up to 1-90% (acylation percentage) --COR (I) where R indicates an alkyl group having 2 to 4 carbon atoms, or a carboxylated alkyl group expressed by --(CH 2 )mCOOH (m is 2 or 3) or --CH═CHCOOH, wherein the balance composition comprises serum proteins or derivatives thereof other than I g M.
Claim 7
Dependent Claim
99 words
An immunoglobulin preparation for intravenous injection use which contains 20% by weight or more of I g M derivatives into which acyl groups expressed by the following formula (I) are introduced to make their anticomplement activity weak by acylating the free amino groups existing in I g M up to 1-90% (acylation percentage) --COR (I) where R indicates an alkyl group having 2 to 4 carbon atoms, or a carboxylated alkyl group expressed by --(CH 2 )mCOOH (m is 2 or 3) or --CH═CHCOOH, wherein the balance composition comprises serum proteins or derivatives thereof other than I g M.
Claim 8
Dependent Claim
39 words
A process as in claim 3, wherein the acylating agent is selected from the group consisting of acetic acid, propionic acid, butyric acid, valeric acid, succinic acid, glutaric acid, maleic acid, or an anhydride, acid chloride or ester thereof.
Claim 9
Dependent Claim
12 words
The process of claim 3, wherein said acylating is conducted in water.
Claim 10
Dependent Claim
34 words
The process of claim 6, wherein said acylating is at a pH of 6 to 10, at a temperature of 50° C. or lower and for a time of 5 minutes to 5 hours.
Claim 11
Dependent Claim
19 words
The process of claim 7, wherein said acylating is conducted with stirring which does not cause denaturation of globulin.
Claim 12
Dependent Claim
24 words
The process of claim 8, wherein after acylating is completed the I g M derivative is obtained by dialyzing the reaction mixture against water.
Claim 13
Dependent Claim
15 words
A preparation as claimed in claim 4, wherein the acylation percentage is 1 to 30%.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-10-25 | 1986-04-26 | 1986-10-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-10-25 | 1990-04-26 | 1990-10-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-10-25 | 1994-04-26 | 1994-10-26 | $7700.00 | Window Closed / Lapsed |