Tricyclic-substituted piperidine antihistamines

Claim 1

A compound represented by the formula ##STR14## wherein n is 1 or 2; R 2 is hydrogen or C 1 to C 3 alkyl; X is hydrogen or halogen; Z is an alklyene chain having 0 to 2 carbon atoms in the chain, said 2 carbon chain optionally having one double bond, said chain optionally having either a carbonyl oxygen or a hydroxy group as a substituent; and Y is --COOR or --SO 2 R, with the proviso that when Y is --COOR, R is C 1 to C 12 alkyl, substituted C 1 to C 12 alkyl, C 2 to C 12 alkenyl, substituted C 2 to C 12 alkenyl, phenyl, substituted phenyl, C 7 to C 10 phenylalkyl or C 7 to C 10 phenylalkyl wherein the phenyl moiety is substituted, or R is -2, -3, or -4 piperidyl or N-substituted piperidyl, wherein the substituents on said substituted C 1 to C 12 alkyl and on said substituted C 2 to C 12 alkenyl are selected from amino or substituted amino and the substituents on said substituted amino are selected from C 1 to C 6 alkyl, the substituents on said substituted phenyl and on said substituted phenyl moiety of the C 7 to C 10 phenylalkyl are selected from C 1 to C 4 alkyl and halo, and the substituent on said N-substituted piperidyl is C 1 to C 4 alkyl, and with the proviso that when Y is --SO 2 R, R is C 1 to C 12 alkyl, C 2 to C 12 alkenyl, phenyl, substituted pheny, C 7 to C 10 phenylalkyl, C 7 to C 10 phenylalkyl wherein the phenyl moiety is substituted, wherein the substituents on said substituted phenyl and said substituted phenyl moiety of the C 7 to C 10 phenylalkyl are selected from C 1 to C 4 alkyl and halo.