US4353896A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Penetrating topical medicament
Assignee: Individual
•
Filing: 1981-06-08
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Granted: 1982-10-12
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Expires: 2001-06-08
Abstract
Abstract An improved topical medicament useful in treating athletic injuries or other painful subdermal conditions is provided which includes a penetrating solvent such as dimethylsulfoxide (DMSO) along with, in preferred forms, a corticosteroid (e.g., hydrocortisone acetate), a counterirritant/analgesic such as methyl salicylate, and one or more emulsifiers, a rubifacient and an alcoholic carrier. The medicaments hereof, when applied topically, are absorbed through the skin and serve to transport the corticosteroid and/or analgesic to a site of inflammation. The preferred salicylate component is converted to the analgesic salicyic acid and active metabolites in the bloodstream to serve as a pain killing agent (i.e., a prostaglandin inhibitor). The compositions hereof may be in the form of lotions, creams or aerosols, depending upon desired end use.
Inventors
- 👤 Michael A. Levy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 18:05
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0014; A61K31/00; A61K31/56; A61K31/57; A61K31/60; A61K47/00; A61K47/06; A61K47/20
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
83 words
A penetrating topical medicament, comprising: from about 0.5 to 5% by volume of a member selected from the group consisting of the corticosteroids, derivatives of the corticosteroids, and mixtures thereof; from about 10 to 35% by volume of a substance selected from the group consisting of methyl salicylate, triethanolamine salicylate, salicyamide, oil of eucalyptus menthol and mixtures thereof; and from about 5 to 50% by volume of a medium for transporting said at least said member through the skin to a subcutaneous site.
Claim 2
Dependent Claim
83 words
A penetrating topical medicament, comprising: from about 0.5 to 5% by volume of a member selected from the group consisting of the corticosteroids, derivatives of the corticosteroids, and mixtures thereof; from about 10 to 35% by volume of a substance selected from the group consisting of methyl salicylate, triethanolamine salicylate, salicyamide, oil of eucalyptus menthol and mixtures thereof; and from about 5 to 50% by volume of a medium for transporting said at least said member through the skin to a subcutaneous site.
Claim 3
Dependent Claim
33 words
The medicament as set forth in claim 1, including an agent selected from the group consisting of sodium lauryl sulfate, stearyl alcohol, cetyl alcohol, glycerol monostearate, polyethylene glycol, bentonite, tragacanth, and mixtures thereof.
Claim 4
Dependent Claim
22 words
The medicament as set forth in claim 1, said agent being present at a level of up to about 15% by volume.
Claim 5
Dependent Claim
11 words
The medicament as set forth in claim 1, including a rubefacient.
Claim 6
Dependent Claim
12 words
The medicament as set forth in claim 4, said rubefacient being camphor.
Claim 7
Dependent Claim
22 words
The medicament as set forth in claim 4, said rubefacient being present at a level of up to about 5% by volume.
Claim 8
Dependent Claim
21 words
The medicament as set forth in claim 1, said member being selected from the group consisting of hydrocortisone and derivatives thereof.
Claim 9
Dependent Claim
13 words
The medicament as set forth in claim 1, said medium being dimethyl sulfoxide.
Claim 10
Dependent Claim
14 words
The medicament as set forth in claim 1, said medium being a lower alcohol.
Claim 11
Dependent Claim
40 words
A penetrating topical medicament, comprising: from about 5 to 90% by volume of dimethyl sulfoxide; and from about 10 to 35% by volume of a member selected from the group consisting of methyl salicylate, triethanolamine salicylate, salicyamide and mixtures thereof.
Claim 12
Dependent Claim
40 words
A penetrating topical medicament, comprising: from about 5 to 90% by volume of dimethyl sulfoxide; and from about 10 to 35% by volume of a member selected from the group consisting of methyl salicylate, triethanolamine salicylate, salicyamide and mixtures thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-10-11 | 1986-04-12 | 1986-10-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-10-11 | 1990-04-12 | 1990-10-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-10-11 | 1994-04-12 | 1994-10-12 | $7700.00 | Window Closed / Lapsed |