US4352793A
Expired / Lapsed
US
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Pharmaceutical composition comprising bencyclane fumarate and cyclodextrin
Assignee: Sumitomo Chemical Co Ltd
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Filing: 1980-04-08
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Granted: 1982-10-05
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Expires: 2000-04-08
Abstract
Abstract A composition comprising as the pharmaceutically active ingredient bencyclane fumarate and cyclodextrin. As compared with prior bencyclane fumarate preparations, this composition can greatly decrease the adverse effects of bencyclane fumarate and, in addition, offers considerable advantages from the viewpoints of method of use and method of production of preparation.
Inventors
- 👤 Yoshiya Yamahira
- 👤 Takeshi Noguchi
- 👤 Keiji Fujioka
- 👤 Tetsuo Noguchi
- 👤 Shigeji Sato
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 04:58
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/135; A61K47/00; A61K47/50; A61K47/69; A61K47/6949; A61K47/6951; B; B82; B82Y; B82Y5/00
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
32 words
A pharmaceutical composition having anticonvulsant and vasodilatory activity comprising as a pharmaceutically active ingredient an effective amount of bencyclane fumarate and cyclodextrin in a molar ratio ranging between about 1:5 and 5:1.
Claim 2
Dependent Claim
32 words
A pharmaceutical composition having anticonvulsant and vasodilatory activity comprising as a pharmaceutically active ingredient an effective amount of bencyclane fumarate and cyclodextrin in a molar ratio ranging between about 1:5 and 5:1.
Claim 3
Dependent Claim
18 words
A composition according to claim 1 wherein said composition comprises an inclusion compound of bencyclane fumarate and cyclodextrin.
Claim 4
Dependent Claim
13 words
A composition according to claim 1 or 2 wherein said cyclodextrin is β-cyclodextrin.
Claim 5
Dependent Claim
13 words
A composition according to claim 1 or 2 wherein said cyclodextrin is γ-cyclodextrin.
Claim 6
Dependent Claim
27 words
A composition according to claim 1 or 2 wherein the ratio of bencyclane fumarate to cyclodextrin is in the range of about 1:2 to 2:1 by mole.
Claim 7
Dependent Claim
21 words
A composition according to claim 1 or 2 wherein the ratio of bencyclane fumarate to cyclodextrin is about 1:1 by mole.
Claim 8
Dependent Claim
22 words
A process for producing the composition of claim 1, the process comprising mixing together bencyclane fumarate and cyclodextrin in said molar ratio.
Claim 9
Dependent Claim
35 words
A process according to claim 7, wherein the method of mixing comprises kneading bencyclane fumarate and cyclodextrin together with water or a solvent mixture comprising water and at least one organic solvent miscible with water.
Claim 10
Dependent Claim
34 words
A process according to claim 7, wherein the method of mixing comprises dissolving bencyclane fumarate and cyclodextrin into water or a solvent mixture comprising water and at least one organic solvents miscible with water.
Claim 11
Dependent Claim
30 words
A process according to claim 8 or 9, wherein said organic solvent miscible with water is selected from the group consisting of methanol, ethanol, acetone, n-propyl alcohol and isopropyl alcohol.
Claim 12
Dependent Claim
19 words
A process according to claim 7, wherein the method of mixing comprises mixing and pulverizing bencyclane fumarate and cyclodextrin.
Claim 13
Dependent Claim
31 words
A process according to any one of claims 7-9 and 11, wherein said bencyclane fumarate and said cyclodextrin are used in an amount expressed by a molar ratio of about 1:1.
Claim 14
Dependent Claim
16 words
A process according to any one of claims 7-9 and 11, wherein said cyclodextrin is β-cyclodextrin.
Claim 15
Dependent Claim
16 words
A process according to any one of claims 7-9 and 11, wherein said cyclodextrin is γ-cyclodextrin.
Claim 16
Dependent Claim
8 words
An inclusion compound of bencyclane fumarate and β-cyclodextrin.
Claim 17
Dependent Claim
8 words
An inclusion compound of bencyclane fumarate and β-cyclodextrin.
Claim 18
Dependent Claim
18 words
An inclusion compound according to claim 15, wherein the ratio of bencyclane fumarate to β-cyclodextrin is about 1:1.
Claim 19
Dependent Claim
25 words
A composition according to claim 3 wherein the ratio of bencyclane fumarate to cyclodextrin is in the range of about 1:2 to 2:1 by mole.
Claim 20
Dependent Claim
25 words
A composition according to claim 4 wherein the ratio of bencyclane fumarate to cyclodextrin is in the range of about 1:2 to 2:1 by mole.
Claim 21
Dependent Claim
19 words
A composition according to claim 3 wherein the ratio of bencyclane fumarate to cyclodextrin is about 1:1 by mole.
Claim 22
Dependent Claim
19 words
A composition according to claim 4 wherein the ratio of bencyclane fumarate ty cyclodextrin is about 1:1 by mole.
Claim 23
Dependent Claim
19 words
A composition according to claim 5 wherein the ratio of bencyclane fumarate to cyclodextrin is about 1:1 by mole.
References Cited (Backward Citations)
US4228160A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-10-04 | 1986-04-05 | 1986-10-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-10-04 | 1990-04-05 | 1990-10-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-10-04 | 1994-04-05 | 1994-10-05 | $7700.00 | Window Closed / Lapsed |