Imidazole hydrazone derivatives

Abstract

Abstract Compounds corresponding to the following general formula: ##STR1## wherein Ar and Ar 1 , which may be the same or different, each represents an aromatic radical which may be substituted one or more times by halogen and/or nitro and/or lower alkyl and/or trihalomethyl and/or cyano and/or lower alkoxy and/or di-lower alkyl-amino, the alkyl groups optionally completing a ring optionally incorporating a further heteroatom, and/or lower alkyl sulphonyl; Alk 1 and Alk 2 , which may be the same or different, each represents an alkylene group containing from one to eight carbon atoms which may be substituted one or more times by aryl and/or cycloalkyl and/or lower alkyl and if two such alkyl groups are present, they may complete a ring optionally containing a heteroatom and in which imidazole ring may be further substituted; and m represents 0 or 1; provided that not both Ar and Ar 1 represent phenyl; and acid addition salts thereof. Such compounds are prepared by reaction of a compound corresponding to the following general formula: ##STR2## with a compound of the formula: Ar.sup.1 --NH--NH.sub.2 The compounds have an anti-fungal activity as well as an antianaerobic and anti-thrombotic activity.

Inventors

• 👤 Peter J. Fellner
• 👤 Brendan J. Hamill
• 👤 Paul W. Manley

Bibliographic Details