US4351769A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antibiotic composition of matter
Assignee: Pharmacia and Upjohn Co
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Filing: 1980-08-25
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Granted: 1982-09-28
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Expires: 2000-08-25
Abstract
Abstract Novel antibiotic U-61,732 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Saccharopolyspora hirsuta strain 367, NRRL 12045. This antibiotic is active against gram-positive bacteria, for example, Staphylococcus aureus. Also disclosed are the 11-acyl esters of U-61,732. Thus, these compounds can be used in various environments to eradicate or control such bacteria.
Inventors
- 👤 Howard A. Whaley
- 👤 John H. Coats
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 04:42
CPC Classifications
C; C07; C07D; C07D493/00; C07D493/02; C07D493/10; C12; C12N; C12N1/00; C12N1/20; C12N1/205; C12P; C12P17/00; C12P17/18; C12P17/181; C12R; C12R2001/00; C12R2001/01
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
48 words
A compound of the formula ##STR3## wherein R is H or an hydrocarbon carboxylic acid acyl of from 2 to 18 carbon atoms, inclusive; or a halo-, nitro-, hydroxy-, amino-, cyano-, thiocyano-, or loweralkoxy-substituted hydrocarbon carboxylic acid acyl of from 2 to 18 carbon atoms, inclusive; and loweralkoxycarbonyl.
Claim 2
Dependent Claim
48 words
A compound of the formula ##STR3## wherein R is H or an hydrocarbon carboxylic acid acyl of from 2 to 18 carbon atoms, inclusive; or a halo-, nitro-, hydroxy-, amino-, cyano-, thiocyano-, or loweralkoxy-substituted hydrocarbon carboxylic acid acyl of from 2 to 18 carbon atoms, inclusive; and loweralkoxycarbonyl.
Claim 3
Dependent Claim
164 words
A compound of the formula ##STR4## wherein R has the formula ##STR5## wherein X is selected from the group consisting of N, S and O; R 1 , R 2 and R 3 are the same or different and are selected from the group consisting of H, OH, halogen, NO 2 , alkyl of 1 to 8 carbons, inclusive, NH 2 , NR 4 R 5 , wherein R 4 and R 5 are selected from the group consisting of H, OH, and alkyl and substituted alkyl, wherein the alkyl is from 1 to 8 carbon atoms, inclusive, and the substituent on substituted alkyl is selected from the group consisting of OH, halogen, O alkyl, S alkyl, O hydrocarbon carboxylic acid acyl, and N hydrocarbon carboxylic acid acyl, wherein the hydrocarbon carboxylic acid acyl is from 2 to 18 carbon atoms, inclusive; or a halo-, nitro-, hydroxy-, amino-, cyano-, thiocyano-, or loweralkoxy-substituted hydrocarbon carboxylic acid acyl of from 2 to 18 carbon atoms, inclusive.
Claim 4
Dependent Claim
164 words
A compound of the formula ##STR4## wherein R has the formula ##STR5## wherein X is selected from the group consisting of N, S and O; R 1 , R 2 and R 3 are the same or different and are selected from the group consisting of H, OH, halogen, NO 2 , alkyl of 1 to 8 carbons, inclusive, NH 2 , NR 4 R 5 , wherein R 4 and R 5 are selected from the group consisting of H, OH, and alkyl and substituted alkyl, wherein the alkyl is from 1 to 8 carbon atoms, inclusive, and the substituent on substituted alkyl is selected from the group consisting of OH, halogen, O alkyl, S alkyl, O hydrocarbon carboxylic acid acyl, and N hydrocarbon carboxylic acid acyl, wherein the hydrocarbon carboxylic acid acyl is from 2 to 18 carbon atoms, inclusive; or a halo-, nitro-, hydroxy-, amino-, cyano-, thiocyano-, or loweralkoxy-substituted hydrocarbon carboxylic acid acyl of from 2 to 18 carbon atoms, inclusive.
Claim 5
Dependent Claim
57 words
A compound of the formula ##STR6## wherein R the formulae ##STR7## wherein Y is selected from the group consisting of N, S and O; ##STR8## can be at any one of the unoccupied ring carbon atoms; and R 1 is as defined in claim 2 and can be on any one of the unoccupied ring carbon atoms.
Claim 6
Dependent Claim
10 words
Antibiotic U-61,732 of the formula, according to claim 1 ##STR9##
References Cited (Backward Citations)
US4148883A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-09-27 | 1986-03-29 | 1986-09-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-09-27 | 1990-03-29 | 1990-09-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-09-27 | 1994-03-29 | 1994-09-28 | $7700.00 | Window Closed / Lapsed |