Patent US2426204A successfully refreshed from Google Patents.
US4350682A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Cartilage extraction processes and products
Assignee: CATRIX RESEARCH LIMIED PARTNERSHIP A OF DE LP
•
Filing: 1980-04-04
•
Granted: 1982-09-21
•
Expires: 2000-04-04
Abstract
Abstract A biologically active cartilage product is prepared by heating a mixture of crude animal or fish cartilage in water under pressure to form an aqueous cartilage extract, removing suspended matter from the extract and concentrating the extract under vacuum. The product may be dried to form a fine granular material.
Inventors
- 👤 Leslie L. Balassa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:52
CPC Classifications
A; A61; A61Q; A61Q1/00; A61Q1/02; A61Q1/04; A61Q1/06; A61K; A61K35/00; A61K35/12; A61K35/32; A61K35/56; A61K35/60; A61K8/00; A61K8/18; A61K8/96; A61K8/98; A61K8/981; A61K9/00; A61K9/02; A61Q19/00; Y; Y10; Y10S; Y10S424/00; Y10S424/05
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
125 words
The method of producing a biologically active cartilage product which consists of: admixing pieces of raw cartilage derived from a cartilage bearing animal, fish or reptile, with water in the ratio from about 1:100 to 100:1, cartilage to water, heating said admixture in a confined space to a predetermined pressure between 10 and about 60 pounds per square inch at a temperature in the range between about 50° C. and 150° C., maintaining said admixture at said pressure and temperature for a period of time between about five minutes and five hours to form an aqueous cartilage extract containing suspended solid material, and separating said suspended solid material from said aqueous cartilage extract to yield a separated solid material and a separated aqueous cartilage extract.
Claim 2
Independent Claim
125 words
The method of producing a biologically active cartilage product which consists of: admixing pieces of raw cartilage derived from a cartilage bearing animal, fish or reptile, with water in the ratio from about 1:100 to 100:1, cartilage to water, heating said admixture in a confined space to a predetermined pressure between 10 and about 60 pounds per square inch at a temperature in the range between about 50° C. and 150° C., maintaining said admixture at said pressure and temperature for a period of time between about five minutes and five hours to form an aqueous cartilage extract containing suspended solid material, and separating said suspended solid material from said aqueous cartilage extract to yield a separated solid material and a separated aqueous cartilage extract.
Claim 3
Dependent Claim
31 words
The method of claim 1 which comprises concentrating said separated aqueous cartilage extract under a vacuum, said concentrated aqueous cartilage extract having a solids content of between about 45% and 65%.
Claim 4
Dependent Claim
19 words
The method of claim 1 wherein said pressure is between about 10 and about 30 pounds per square inch.
Claim 5
Dependent Claim
16 words
The method of claim 1 wherein said time period is between about 1 and 5 hours.
Claim 6
Dependent Claim
13 words
The method of claim 4 which comprises drying the separated aqueous cartilage extract.
Claim 7
Dependent Claim
28 words
The method of claim 5 wherein said drying step comprises contacting said separated aqueous cartilage extract with a liquid and precipitating the cartilage extract as a wet solid.
Claim 8
Dependent Claim
34 words
The method of claim 6 wherein said drying step comprises removing moisture from said separated aqueous cartilage extract by subjecting said extract to a temperature below 0° C. in the presence of a vacuum.
Claim 9
Dependent Claim
23 words
The method of claim 5 which comprises concentrating said separated aqueous cartilage extract under a vacuum of between about 10 and 100 torr.
Claim 10
Dependent Claim
20 words
The method of claim 5 which comprises drying said separated aqueous cartilage extract by azeotropic distillation with a hydrocarbon azeotrope.
Claim 11
Dependent Claim
21 words
The method of claim 2 wherein said raw cartilage includes a small percentage of the original fat and adhering proteinaceous tissue.
Claim 12
Dependent Claim
16 words
The method of claim 5 wherein said raw cartilage is derived from a cartilage bearing animal.
Claim 13
Dependent Claim
13 words
The method of claim 11 wherein said animal is of the bovine genus.
Claim 14
Dependent Claim
14 words
The method of claim 5 wherein said raw cartilage is derived from a fish.
Claim 15
Dependent Claim
11 words
The method of claim 13 wherein said fish is a shark.
Claim 16
Dependent Claim
17 words
The method of claim 13 wherein said separated aqueous cartilage extract is a gel at room temperature.
Claim 17
Dependent Claim
119 words
A biologically active cartilage product prepared by the process of claim 1 separating substantially all of the organs, skin and integument from cartilage derived from a cartilage bearing animal reptile or fish, admixing said cartilage with water in the ratio between 1:100 and 100:1 cartilage to water, extracting said mixture of cartilage and water at a temperature between about 105° and 125° C. and at a pressure of between about 10 and 60 pounds per square inch for a predetermined time between about 5 minutes and 5 hours, to form an aqueous cartilage extract containing suspended solid material, and further comprises concentrating the solid free aqueous extract under a vacuum, and drying said concentrated extract to a dry product.
Claim 18
Dependent Claim
21 words
The product of claim 16 wherein the concentrating step is conducted by agitating said extract in a thin film evaporator device.
Claim 19
Independent Claim
100 words
The method of producing a biologically active cartilage product which comprises: admixing raw cartilage which has not been subjected to acid pepsin digestion with water, said admixture being in the ratio from 1:100 to 100:1 cartilate to water, heating said admixture to a temperature of between about 50° C. and 125° C. under a pressure of between about 10 and about 30 pounds per square inch, maintaining said admixture at said temperature and pressure for between about 5 minutes and 5 hours to form an aqueous extract containing suspended solid materials, and separating said suspended solid materials from said extract.
Claim 20
Independent Claim
100 words
The method of producing a biologically active cartilage product which comprises: admixing raw cartilage which has not been subjected to acid pepsin digestion with water, said admixture being in the ratio from 1:100 to 100:1 cartilate to water, heating said admixture to a temperature of between about 50° C. and 125° C. under a pressure of between about 10 and about 30 pounds per square inch, maintaining said admixture at said temperature and pressure for between about 5 minutes and 5 hours to form an aqueous extract containing suspended solid materials, and separating said suspended solid materials from said extract.
Claim 21
Dependent Claim
32 words
A shaped lipstick comprising the dried extract of claim 18 and at least one lipstick base selected from the group consisting of hydrogenated vegetable oils, lanolin waxes, lanolin alcohols, beeswax and petrolatum.
Claim 22
Dependent Claim
26 words
A shaped rectal suppository comprising from about 2% to about 5% of the biologically active cartilage product of claim 18, and a hydrogenated vegetable oil base.
Claim 23
Dependent Claim
23 words
The method of claim 18 which comprises separating said suspended solid materials from said extract by filtering said extract through a filter press.
Claim 24
Dependent Claim
19 words
The method of claim 18 which comprises separating said suspended solid materials from said extract by centrifuging said extract.
Claim 25
Dependent Claim
26 words
The method of claim 18 which comprises concentrating said extract by dehydration to form a dry material, and grinding said dry material to a fine powder.
Claim 26
Dependent Claim
17 words
A pharmaceutical formulation comprising a pharmaceutically acceptable liquid and the biologically active cartilage product of claim 20.
Claim 27
Dependent Claim
23 words
The method of claim 2 which comprises combining said separated aqueous cartilage extract with an excess of isopropanol to precipitate a solid material.
Claim 28
Dependent Claim
15 words
The method of claim 1 which comprises subdividing said raw cartilage prior to said admixing.
Claim 29
Dependent Claim
18 words
The method of claim 1 which comprises conducting said heating step in the presence of an oxidizing atmosphere.
References Cited (Backward Citations)
US2320098A
Cited
US3033755A
Cited
FR3186M
Cited
USRE28093E
Cited
CH476495A
Cited
US3400199A
Cited
US3476855A
Cited
US3478146A
Cited
US3551560A
Cited
US3703575A
Cited
US3772432A
Cited
US3966908A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-09-20 | 1986-03-22 | 1986-09-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-09-20 | 1990-03-22 | 1990-09-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-09-20 | 1994-03-22 | 1994-09-21 | $7700.00 | Window Closed / Lapsed |