US4349531A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Novel dosage form
Assignee: Hoffmann La Roche Inc
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Filing: 1979-10-04
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Granted: 1982-09-14
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Expires: 1999-10-04
Abstract
Abstract Pharmaceutical dosage forms comprising an edible web having deposited thereon or at least partially thereon a particulate medicament, the webs being thereafter fabricated and finished to pharmaceutically elegant solid dosage forms having no medicament exposed on an exterior surface. The dosage forms have a consistency of release of medicament which can be controlled to exacting specifications. The disclosed solid dosage forms are prepared by high speed automated equipment and the process by which they are made is characterized by non-destructive quality control analysis and performance evaluation both conducted on-line and integrated into the manufacturing operation. Included in the scope of the disclosed invention are certain apparatus and methods of manufacture.
Inventors
- 👤 Arthur R. Mlodozeniec
- 👤 Arthur H. Goldberg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 21:09
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2072; A61J; A61J3/00; A61K9/2095; A61K9/28; A61K9/70; A61F; A61F13/00; A61F13/02; A61F13/0276; A61F2013/0296
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
167 words
A solid pharmaceutical unit dosage form comprising a laminate composed of a plurality of layers of an edible, therapeutically inert web, at lest two of said layers having a composition comprising one or more medicaments loaded to one or more surfaces in a finely particulate form, said layers of web being arranged in said laminate so that substantially no medicament is loaded to an outer surface thereof, said laminate being sealed only at the contiguous edges so as to completely internalize said medicament, and wherein at least two layers in said laminate consist of a heat sealable polymeric composition comprising an organic film-forming ingredient and a plasticizer therefor and at least one layer in said laminate consists of a paper composition comprising one or more fibrous materials and at least one non-fibrous modifier therefor, the top and bottom layers of said laminate being polymeric with the proviso that there be no more than six of said paper composition webs interspersed between each pair of said polymeric layers.
Claim 2
Dependent Claim
167 words
A solid pharmaceutical unit dosage form comprising a laminate composed of a plurality of layers of an edible, therapeutically inert web, at lest two of said layers having a composition comprising one or more medicaments loaded to one or more surfaces in a finely particulate form, said layers of web being arranged in said laminate so that substantially no medicament is loaded to an outer surface thereof, said laminate being sealed only at the contiguous edges so as to completely internalize said medicament, and wherein at least two layers in said laminate consist of a heat sealable polymeric composition comprising an organic film-forming ingredient and a plasticizer therefor and at least one layer in said laminate consists of a paper composition comprising one or more fibrous materials and at least one non-fibrous modifier therefor, the top and bottom layers of said laminate being polymeric with the proviso that there be no more than six of said paper composition webs interspersed between each pair of said polymeric layers.
Claim 3
Dependent Claim
23 words
A solid unit dosage form in accordance with claim 1 wherein said non-fibrous modifier in said paper composition comprises an organic film-forming ingredient.
Claim 4
Dependent Claim
33 words
A solid unit dosage form in accordance with claim 2 wherein said film-forming ingredient in said polymeric composition and said paper composition is selected from the group consisting of hydroxypropylcellulose and sodium carboxymethylcellulose.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-09-13 | 1986-03-15 | 1986-09-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-09-13 | 1990-03-15 | 1990-09-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-09-13 | 1994-03-15 | 1994-09-14 | $7700.00 | Window Closed / Lapsed |