Patent US3481509A successfully refreshed from Google Patents.
US4349529A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Diagnostic and therapeutic capsules and method of producing
Assignee: Bracco International BV
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Filing: 1980-04-14
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Granted: 1982-09-14
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Expires: 2000-04-14
Abstract
Abstract An article of manufacture comprising a pharmaceutical radioactive capsule formed essentially of a non-toxic, water soluble material adapted to being ingested and rapidly disintegrating on contact with fluids of the gastro-intestinal tract, and having a filler material supporting a pharmaceutically useful radioactive compound absorbable from the gastro-intestinal tract said filler material being supported by said capsule. And a method of filling a pharmaceutical radioactive capsule comprising providing filler material supporting a pharmaceutically useful radioactive compound and transporting said filler material carrying a pharmaceutically useful radioactive compound into the chamber of said capsule.
Inventors
- 👤 Nabil A. Morcos
- 👤 Thomas A. Haney
- 👤 Paul W. Wedeking
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 10:45
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/12; A61K51/1262; A61K9/00; A61K9/48; A61K9/4841; A61K9/485; A61K9/4866; A61K2121/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
156 words
An article of manufacture comprising, a pharmaceutical capsule formed essentially of a nontoxic, water soluble material adapted to being ingested and rapidly disintegrating on contact with fluids of the gastro-intestinal tract and a polyethylene glycol filler material having a pharmaceutically useful radioactive iodine and a reducing agent dispersed therein, said capsule having a central axis and an inner surface, said inner surface defining a volume within said capsule, said filler material being supported by said inner surface of said capsule, a major portion of said volume within said capsule containing said filler material, said filler material having a shape which is coextensive with the inner surface of said capsule, said filler material extending radially across the central axis of said capsule, said filler material containing a major portion of said radioactive iodine within the interior of said filler material, whereby said major portion of said radioactive compound does not contact said inner surface of said capsule.
Claim 2
Dependent Claim
156 words
An article of manufacture comprising, a pharmaceutical capsule formed essentially of a nontoxic, water soluble material adapted to being ingested and rapidly disintegrating on contact with fluids of the gastro-intestinal tract and a polyethylene glycol filler material having a pharmaceutically useful radioactive iodine and a reducing agent dispersed therein, said capsule having a central axis and an inner surface, said inner surface defining a volume within said capsule, said filler material being supported by said inner surface of said capsule, a major portion of said volume within said capsule containing said filler material, said filler material having a shape which is coextensive with the inner surface of said capsule, said filler material extending radially across the central axis of said capsule, said filler material containing a major portion of said radioactive iodine within the interior of said filler material, whereby said major portion of said radioactive compound does not contact said inner surface of said capsule.
Claim 3
Dependent Claim
15 words
The article of claim 1 wherein said radioactive iodine is iodine 131 or iodine 123.
Claim 4
Dependent Claim
15 words
The article of claim 1 wherein said capsule is methyl cellulose, polyvinyl alcohol or gelatin.
Claim 5
Dependent Claim
17 words
The article of claim 1 wherein said reducing agent is sodium thiosulfate, sodium sulfite or sodium bisulfite.
Claim 6
Dependent Claim
26 words
The article of claim 1 further comprising a base dispersed throughout said filler material, and said reducing agent is sodium thiosulfate, sodium sulfite or sodium bisulfite.
Claim 7
Independent Claim
85 words
A method of filling a pharmaceutical capsule having an inner surface defining a volume within said capsule, said capsule being formed essentially of a nontoxic, water soluble material adapted to being ingested and rapidly disintegrating on contact with fluids in the gastrointestinal tract comprising providing a polyethylene glycol filler material having a pharmaceutically useful radioactive iodine and a reducing agent dispersed therein and transporting said filler material into said capsule, whereby a major portion of said volume within said capsule is filled with filler material.
Claim 8
Independent Claim
85 words
A method of filling a pharmaceutical capsule having an inner surface defining a volume within said capsule, said capsule being formed essentially of a nontoxic, water soluble material adapted to being ingested and rapidly disintegrating on contact with fluids in the gastrointestinal tract comprising providing a polyethylene glycol filler material having a pharmaceutically useful radioactive iodine and a reducing agent dispersed therein and transporting said filler material into said capsule, whereby a major portion of said volume within said capsule is filled with filler material.
Claim 9
Dependent Claim
25 words
The method of claim 6 wherein said filler material is heated prior to said transporting and said filler material further has a base dispersed therein.
Claim 10
Dependent Claim
31 words
The method of claim 7 wherein said filler is heated to 50° to 60° C. prior to said transporting, and said polyethylene glycol additionally has a base dispersed throughout said filler.
Claim 11
Dependent Claim
31 words
The method of claim 6 wherein said filler material is dissolved in a solvent prior to said transporting and both said filler material and said solvent are transported into said capsule.
Claim 12
Dependent Claim
13 words
The method of claim 9 further comprising removing said solvent from said capsule.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-09-13 | 1986-03-15 | 1986-09-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-09-13 | 1990-03-15 | 1990-09-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-09-13 | 1994-03-15 | 1994-09-14 | $7700.00 | Window Closed / Lapsed |