Autoclavable emulsion containing silver sulphadiazine

Claim 2

A heat sterilized, mobile, drop-forming, ophthalmic oil-in-water emulsion which comprises an aqueous solution of 0.04 to 0.25% of a pharmaceutically acceptable salt of polyacrylic acid lightly cross-linked with triallyl sucrose, a pharmacologically acceptable vegetable or mineral oil and a therapeutically effective amount of finely divided silver sulphadiazine.

Claim 3

An emulsion as claimed in claim 1 which has been sterilized by autoclaving.

Claim 4

An emulsion as claimed in claim 2 which comprises 0.05 to 0.2 wt.% of polyacrylic acid lightly cross-linked with triallyl sucrose.

Claim 5

An emulsion as claimed in claim 3 in which the viscosity of the emulsion is in the range of 50 to 150 cps.

Claim 6

A heat sterilized, mobile, drop-forming, ophthalmic oil-in-water emulsion which comprises an aqueous solution containing 0.06 to 0.16% of a pharmaceutically acceptable salt of a cross-linked polyacrylic acid lightly cross-linked with triallyl sucrose, 5 to 15% of a pharmacologically acceptable vegetable or mineral oil, 0.6 to 1.4% of finely divided silver sulphadiazine and 0.75 to 1.5% of emulsifier selected from the group consisting of sorbitan fatty acid esters, polyoxyethylated sorbitan fatty acid esters and polyoxyethylated-polyoxypropylene diol block copolymers.

Claim 7

A heat sterilized, mobile, drop-forming, ophthalmic oil-in-water emulsion which comprises an aqueous solution containing 0.06 to 0.16% of a pharmaceutically acceptable salt of a cross-linked polyacrylic acid lightly cross-linked with triallyl sucrose, 5 to 15% of a pharmacologically acceptable vegetable or mineral oil, 0.6 to 1.4% of finely divided silver sulphadiazine and 0.75 to 1.5% of emulsifier selected from the group consisting of sorbitan fatty acid esters, polyoxyethylated sorbitan fatty acid esters and polyoxyethylated-polyoxypropylene diol block copolymers.

Claim 8

A heat sterilized, mobile, drop forming, ophthalmic oil-in-water emulsion consisting essentially of an aqueous solution containing 0.06 to 0.16% of a pharmaceutically acceptable salt of a cross-linked polyacrylic acid lightly cross-linked with triallyl sucrose, 5 to 15% of a pharmacologically acceptable vegetable or mineral oil, a therapeutically effective amount of finely divided silver sulphadiazine effective when applied topically to the eye, and 0.75 to 1.5% of an emulsifier selected from the group consisting of sorbitan fatty acid, esters, polyethoxylated sorbitan fatty acid esters and polyethylated-polyoxypropylene diol block copolymers.

Claim 9

A heat sterilized, mobile, drop forming, ophthalmic oil-in-water emulsion consisting essentially of an aqueous solution containing 0.06 to 0.16% of a pharmaceutically acceptable salt of a cross-linked polyacrylic acid lightly cross-linked with triallyl sucrose, 5 to 15% of a pharmacologically acceptable vegetable or mineral oil, a therapeutically effective amount of finely divided silver sulphadiazine effective when applied topically to the eye, and 0.75 to 1.5% of an emulsifier selected from the group consisting of sorbitan fatty acid, esters, polyethoxylated sorbitan fatty acid esters and polyethylated-polyoxypropylene diol block copolymers.