US4344936A
Expired / Lapsed
US
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Platelet composition having improved storage stability and method therefor
Assignee: Individual
•
Filing: 1980-09-17
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Granted: 1982-08-17
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Expires: 2000-09-17
Abstract
Abstract There is disclosed, in one aspect, a composition for improving the storage stability of blood platelets comprising the platelets, a container for the platelets, and a sialyl compound having the structural formula (I) ##STR1## wherein Ac is an acetyl group, R is a carbohydrate group, n is an integer of 1 or more, preferably 1, and the R and N-acetyl groups replace hydrogen atoms or hydroxyl groups on the ring. In another aspect, there is disclosed a method for increasing the storage stability of these platelets. This method comprises admixing with the platelets a compound having the structural formula (I) described above, wherein Ac, R, and n have the meanings described above.
Inventors
- 👤 Gerald Soslau
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 11:48
CPC Classifications
C; C07; C07H; C07H13/00; C07H13/12; A; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/19
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
72 words
A composition for improving the storage stability of blood platelets comprising (a) said platelets, (b) a container for said platelets, and (c) an effective amount of a sialyl compound having the structural formula (I) ##STR5## wherein Ac is an acetyl group, R is a carbohydrate group, n is an integer of 1 or more, and the R group replaces an hydroxyl group on the ring and the N-acetyl group replaces hydroxyl groups.
Claim 2
Dependent Claim
72 words
A composition for improving the storage stability of blood platelets comprising (a) said platelets, (b) a container for said platelets, and (c) an effective amount of a sialyl compound having the structural formula (I) ##STR5## wherein Ac is an acetyl group, R is a carbohydrate group, n is an integer of 1 or more, and the R group replaces an hydroxyl group on the ring and the N-acetyl group replaces hydroxyl groups.
Claim 3
Dependent Claim
27 words
The composition of claim 1, wherein the amount of sialyl compound is less than 0.04% by weight based upon the volume of 100 milliliters of platelet concentrate.
Claim 4
Dependent Claim
20 words
The composition of claim 1, wherein said sialyl compound has the structural formula (III) ##STR6## wherein R is a carbohydrate.
Claim 5
Dependent Claim
19 words
The composition of claim 3, wherein R is a member selected from the group consisting of lactose and galactose.
Claim 6
Dependent Claim
12 words
The composition of claim 1, wherein said container is a plastic bag.
Claim 7
Independent Claim
65 words
A method for increasing the storage stability of blood platelets comprising admixing with said platelets an effective amount of a sialyl compound having the structural formula (I) ##STR7## wherein Ac is an acetyl group, R is a carbohydrate group, n is an integer of 1 or more, and the R group replaces an hydroxyl group on the ring and the N-acetyl group replaces hydroxyl groups.
Claim 8
Independent Claim
65 words
A method for increasing the storage stability of blood platelets comprising admixing with said platelets an effective amount of a sialyl compound having the structural formula (I) ##STR7## wherein Ac is an acetyl group, R is a carbohydrate group, n is an integer of 1 or more, and the R group replaces an hydroxyl group on the ring and the N-acetyl group replaces hydroxyl groups.
Claim 9
Dependent Claim
28 words
The method of claim 6, wherein the amount of sialyl compound is less than about 0.04% by weight based upon the volume of 100 milliliters of platelet concentrate.
Claim 10
Dependent Claim
20 words
The method of claim 6, wherein said sialyl compound has the structural formula (III) ##STR8## wherein R is a carbohydrate.
Claim 11
Dependent Claim
19 words
The method of claim 8, wherein R is a member selected from the group consisting of lactose and galactose.
References Cited (Backward Citations)
No citation records indexed.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-08-16 | 1986-02-15 | 1986-08-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-08-16 | 1990-02-15 | 1990-08-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-08-16 | 1994-02-15 | 1994-08-17 | $7700.00 | Window Closed / Lapsed |