US4343940A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anti-tumor quinazoline compounds
Assignee: Mead Johnson and Co LLC
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Filing: 1981-03-06
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Granted: 1982-08-10
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Expires: 2001-03-06
Abstract
Abstract 4-Ethyl-6-methoxy-7-(oxiranylmethoxy)quinazoline and its isomer 4-ethyl-7-methoxy-6-(oxiranylmethoxy)quinazoline have potent anti-tumor activity in animals.
Inventors
- 👤 William E. Kreighbaum
- 👤 William T. Comer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 19:31
CPC Classifications
C; C07; C07D; C07D239/00; C07D239/70; C07D239/72; C07D239/74; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
90 words
A compound having Formula I ##STR14## wherein one of R 6 and R 7 is oxiranylmethyl, and the other is methyl or oxiranylmethyl, and R 2 and R 4 are independently selected from the group consisting of hydrogen, alkyl having from 1 to 5 carbon atoms, phenyl, substituted phenyl, phenylalkyl having up to 8 carbon atoms, substituted phenylalkyl having up to 8 carbon atoms apart from the substituents, wherein said substituted phenyl and substituted phenylalkyl have one or two ring attached groups independently selected from halogen, methyl, or methoxy groups.
Claim 2
Dependent Claim
90 words
A compound having Formula I ##STR14## wherein one of R 6 and R 7 is oxiranylmethyl, and the other is methyl or oxiranylmethyl, and R 2 and R 4 are independently selected from the group consisting of hydrogen, alkyl having from 1 to 5 carbon atoms, phenyl, substituted phenyl, phenylalkyl having up to 8 carbon atoms, substituted phenylalkyl having up to 8 carbon atoms apart from the substituents, wherein said substituted phenyl and substituted phenylalkyl have one or two ring attached groups independently selected from halogen, methyl, or methoxy groups.
Claim 3
Dependent Claim
6 words
The compound of claim 1, 4-ethyl-6-methoxy-7-(oxiranylmethoxy)quinazoline.
Claim 4
Dependent Claim
6 words
The compound of claim 1, 4-ethyl-7-methoxy-6-(oxiranylmethoxy)quinazoline.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-08-09 | 1986-02-08 | 1986-08-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-08-09 | 1990-02-08 | 1990-08-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-08-09 | 1994-02-08 | 1994-08-10 | $7700.00 | Window Closed / Lapsed |