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US4343788A Expired / Lapsed US ⏱️ 0.0 years remaining

Antimicrobial polymer compositions

Assignee: Procter and Gamble Co
•
Filing: 1979-06-29
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Granted: 1982-08-10
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Expires: 1999-06-29
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Abstract

Abstract The present invention relates to medical polymers and devices made therefrom, and is based on the discovery that certain carboxylate antimicrobial agents can be releasably incorporated into permeable polymers. The walls of medical devices such as catheters can be fashioned from such polymers. In use, the antimicrobial agent diffuses from the walls to the surface of the device to form an antimicrobial barrier on the surface of the device and a zone of microbial inhibition on tissue surfaces surrounding the device, thereby effectively supplementing the body's own natural microbial barriers where they have been compromised. The bacterial contamination-resistant carboxylate-plus-polymer compositions herein can be used in the manufacture of a wide variety of medical devices, especially urinary catheters, intravenous catheters, wound dressings, and the like.

Inventors

  • 👤 Robert V. Mustacich
  • 👤 Donald S. Lucas
  • 👤 Roger L. Stone

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 00:09
CPC Classifications
A; A61; A61L; A61L29/00; A61L29/14; A61L29/16; A01; A01N; A01N37/00; A01N37/02; A01N37/06; A61L15/00; A61L15/16; A61L15/42; A61L15/46; A61P; A61P31/00; A61L2300/00; A61L2300/20; A61L2300/21; A61L2300/40; A61L2300/404

Claims Analysis

Total Claims: 5
Claim 1
Independent Claim 88 words
A composition of matter, comprising: a toxicologically-acceptable, medical-grade elastomeric polymer, said polymer having releasably incorporated within the polymer matrix a safe and effective amount of one or more free n-alkane monocarboxylic acid antimicrobial agents or salts thereof, having from about 4 to about 10 carbon atoms, said polymer containing from about 0.1% to about 40% by weight of a substantially non-antimicrobial proton donor selected from the group consisting of citric acid, tartaric acid, malic acid, fumaric acid, maleic acid, malonic acid, ascorbic acid, barbituric acid, and mixtures thereof.
Claim 2
Dependent Claim 88 words
A composition of matter, comprising: a toxicologically-acceptable, medical-grade elastomeric polymer, said polymer having releasably incorporated within the polymer matrix a safe and effective amount of one or more free n-alkane monocarboxylic acid antimicrobial agents or salts thereof, having from about 4 to about 10 carbon atoms, said polymer containing from about 0.1% to about 40% by weight of a substantially non-antimicrobial proton donor selected from the group consisting of citric acid, tartaric acid, malic acid, fumaric acid, maleic acid, malonic acid, ascorbic acid, barbituric acid, and mixtures thereof.
Claim 3
Dependent Claim 40 words
A composition according to claim 1 wherein the antimicrobial agent is in the form of one or more pharmaceutically-acceptable alkali metal salts of the n-alkane monocarboxylic acid and comprises from about 0.01% to about 60% by weight of the composition.
Claim 4
Dependent Claim 24 words
A composition according to claim 1, wherein the antimicrobial agent is selected from the group consisting of octanoic acid, sodium octanoate, or mixtures thereof.
Claim 5
Dependent Claim 22 words
A composition according to claim 1 wherein the antimicrobial agent comprises from about 0.01% to about 60% by weight of the composition.

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1985-08-09 1986-02-08 1986-08-10 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1989-08-09 1990-02-08 1990-08-10 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1993-08-09 1994-02-08 1994-08-10 $7700.00 Window Closed / Lapsed

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