US4340730A
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N6 -Substituted adenosines
Assignee: GD Searle LLC
•
Filing: 1981-01-30
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Granted: 1982-07-20
•
Expires: 2001-01-30
Abstract
Abstract Novel N 6 -adenosines according to formula I are disclosed. These novel compounds are useful as antihypertensive agents.
Inventors
- 👤 Richard E. L. Henderson
- 👤 Nancy J. Malek
- 👤 Alan E. Moormann
- 👤 Barnett S. Pitzele
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 22:49
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/16
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
110 words
A compound according to the formula: where in R 1 is: (a) hydrogen; or (b) alkyl of from 1 to 6 carbon atoms inclusive; where R 2 is: (a) 4-(N,N-dimethylaminophenethyl); (b) --(CH 2 ) n COOR 5 ; wherein n is an integer from 3 to 11 inclusive; wherein R 5 is: (a) hydrogen; or (b) alkyl of from 1 to 20 carbon atoms, inclusive with the provision that when R 1 is hydrogen and n is 5, R 5 cannot be hydrogen; (c) 3(11,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl; or wherein R 1 and R 2 taken together with N form a piperazine ring of the formula: ##STR2## wherein R 4 is: (a) ethoxycarbonyl.
Claim 2
Dependent Claim
110 words
A compound according to the formula: where in R 1 is: (a) hydrogen; or (b) alkyl of from 1 to 6 carbon atoms inclusive; where R 2 is: (a) 4-(N,N-dimethylaminophenethyl); (b) --(CH 2 ) n COOR 5 ; wherein n is an integer from 3 to 11 inclusive; wherein R 5 is: (a) hydrogen; or (b) alkyl of from 1 to 20 carbon atoms, inclusive with the provision that when R 1 is hydrogen and n is 5, R 5 cannot be hydrogen; (c) 3(11,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl; or wherein R 1 and R 2 taken together with N form a piperazine ring of the formula: ##STR2## wherein R 4 is: (a) ethoxycarbonyl.
Claim 3
Dependent Claim
11 words
A compound according to claim 1 wherein R 1 is hydrogen.
Claim 4
Dependent Claim
9 words
N 6 -[4-(N,N-dimethylamino)phenethyl]adenosine a compound according to claim 2.
Claim 5
Dependent Claim
29 words
A compound according to claim 2 wherein R 2 is --(CH 2 ) n COOR 5 and R 5 is alkyl of from 1 to 20 carbon atoms inclusive.
Claim 6
Dependent Claim
9 words
N 6 -[4-ethoxycarbonyl)butyl]adenosine a compound according to claim 4.
Claim 7
Dependent Claim
38 words
A compound according to claim 2 wherein R 2 is --(CH 2 ) n COOR 5 and R 5 is hydrogen, with the provision that when n is not equal to 5, then R 1 is not Hydrogen.
Claim 8
Dependent Claim
9 words
N 6 -(4-carboxybutyl)adenosine a compound according to claim 6.
Claim 9
Dependent Claim
19 words
A compound according to claim 1 wherein R 1 is alkyl of from 1 to 6 carbon atoms inclusive.
Claim 10
Dependent Claim
11 words
A compound according to claim 8 wherein R 1 is methyl.
Claim 11
Dependent Claim
11 words
N 6 -[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]-N 6 -methyladenosine a compound according to claim 9.
Claim 12
Dependent Claim
21 words
A compound according to claim 8 wherein R 2 is --(CH 2 ) n COOR 5 and R 5 is hydrogen.
Claim 13
Dependent Claim
11 words
N 6 -methyl-N 6 -(3-carboxypropyl)adenosine a compound according to claim 11.
Claim 14
Dependent Claim
28 words
A compound according to claim 8 wherein R 2 is --(CH 2 ) n COOR 5 and R 5 is alkyl of 1 to 20 carbon atoms inclusive.
Claim 15
Dependent Claim
11 words
N 6 -methyl-N 6 -[3-ethoxycarbonyl)propyl]adenosine a compound according to claim 13.
Claim 16
Dependent Claim
23 words
A compound according to claim 1 wherein R 1 and R 2 taken together with N form a piperazine ring of formula II.
Claim 17
Dependent Claim
8 words
6-[4-ethoxycarbonyl)-1-piperazinyl]purine riboside, a compound according to claim 15.
References Cited (Backward Citations)
US3983104A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-07-19 | 1986-01-18 | 1986-07-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-07-19 | 1990-01-18 | 1990-07-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-07-19 | 1994-01-18 | 1994-07-20 | $7700.00 | Window Closed / Lapsed |