US4339500A
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US
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Hydrophilic packing material for chromatography
Assignee: Asahi Kasei Corp
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Filing: 1980-10-14
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Granted: 1982-07-13
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Expires: 2000-10-14
Abstract
Abstract Grains of a totally porous, hydroxyl group-containing, nonionic and hydrophilic synthetic cross-linked polymer having alcoholic hydroxyl and ether groups as main hydrophilic groups and having as a main skeleton a chemical structure including carbon atoms, hydrogen atoms and oxygen atoms bonded through single bonds, said synthetic polymer having a hydroxyl group density of 1 to 15 milliequivalents/g, a specific surface area of 5 to 1000 m 2 /g and a water regain of 0.3 to 3.0 g/g. Such grains have been found to be a packing material or gel for high speed, aqueous gel permeation chromatography. The packing material of the present invention which comprises grains of a hydroxyl group-containing nonionic and hydrophilic synthetic cross-linked polymer has a chemical structure obtained by reacting a totally porous, hydroxyl group-containing, nonionic polymer with a polyfunctional substance capable of reacting with the hydroxyl groups of said polymer while forming cross-linking ether groups.
Inventors
- 👤 Yuzo Yanagihara
- 👤 Kohji Noguchi
- 👤 Hiroshi Suzuki
- 👤 Makoto Honda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 20:49
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/281; B01J20/291; B01J20/22; B01J20/26; B01J20/261; B01J20/265; B01J20/267; B01J20/282; B01J20/285; C; C08; C08J; C08J3/00; C08J3/12; C08J9/00; C08J9/36; B01D; B01D15/00; B01D15/08; B01D15/26; B01D15/34; B01J2220/00; B01J2220/50; B01J2220/54; C08J2329/00; C08J2329/02; C08J2329/04; Y; Y10; Y10S; Y10S521/00; Y10S521/905; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
111 words
A totally porous, hydrophilic packing material for chromatography which comprises grains of a hydroxyl group-containing nonionic and hydrophilic synthetic cross-linked polymer having as a main skeleton a chemical structure including carbon atoms, hydrogen atoms and oxygen atoms bonded through single bonds, which atoms are present in the form of hydroxyl groups, ether groups, carbon-hydrogen bonds and carbon-carbon single bonds exclusive of oxygen-oxygen bonds and 3- or 4- membered rings consisting of carbon and oxygen atoms, said synthetic polymer in dry state having a hydroxyl group density of 1 to 15 milliequivalents/g, a specific surface area of 5 to 1000 m 2 /g and a water regain of 0.3 to 3.0 g/g.
Claim 2
Dependent Claim
111 words
A totally porous, hydrophilic packing material for chromatography which comprises grains of a hydroxyl group-containing nonionic and hydrophilic synthetic cross-linked polymer having as a main skeleton a chemical structure including carbon atoms, hydrogen atoms and oxygen atoms bonded through single bonds, which atoms are present in the form of hydroxyl groups, ether groups, carbon-hydrogen bonds and carbon-carbon single bonds exclusive of oxygen-oxygen bonds and 3- or 4- membered rings consisting of carbon and oxygen atoms, said synthetic polymer in dry state having a hydroxyl group density of 1 to 15 milliequivalents/g, a specific surface area of 5 to 1000 m 2 /g and a water regain of 0.3 to 3.0 g/g.
Claim 3
Dependent Claim
20 words
A packing material according to claim 1, wherein said grains have an average grain diameter of 1 to 2,000 μm.
Claim 4
Dependent Claim
20 words
A packing material according to claim 1, wherein said grains have an average grain diameter of 2 to 500 μm.
Claim 5
Dependent Claim
20 words
A packing material according to claim 1, wherein said grains have an average grain diameter of 2 to 50 μm.
Claim 6
Dependent Claim
44 words
A packing material according to claim 1, wherein said chemical structure including carbon atoms, hydrogen atoms and oxygen atoms bonded through single bonds is present in an amount of 97% or more by weight based on the entire skeleton of said synthetic cross-linked polymer.
Claim 7
Dependent Claim
110 words
A packing material according to claim 1, wherein said chemical structure is one obtained by reacting a totally porous, hydroxyl group-containing nonionic polymer having a specific surface area of not more than 1 m 2 /g as measured upon drying the polymer which has been immersed or dissolved in water and a hydroxyl group density of 5 to 23 milliequivalents/g with 10 to 600% by weight, based on said totally porous, hydroxyl group-containing nonionic polymer, of a polyfunctional substance capable of reacting with the hydroxyl groups of said polymer while forming cross-linking ether groups, the reaction being effected in such a solvent as will not dissolve or swell polyvinyl alcohol.
Claim 8
Dependent Claim
26 words
A packing material according to claim 6, wherein said totally porous, hydroxyl group-containing nonionic polymer includes therein at least vinyl alcohol units and/or allyl alcohol units.
Claim 9
Dependent Claim
40 words
A packing material according to claim 6, wherein said totally porous, hydroxyl group-containing nonionic polymer is a linear polymer selected from the group consisting of a polyvinyl alcohol, a polyallyl alcohol and a copolymer of vinyl alcohol with allyl alcohol.
Claim 10
Dependent Claim
61 words
A packing material according to claim 6, wherein said totally porous, hydroxyl group-containing nonionic polymer has a chemical structure obtained by saponifying a copolymer of a monomer having at least one carboxylic acid vinyl ester group and/or a monomer having at least one carboxylic acid allyl ester group with 1,4-butanediol divinyl ether, diethylene glycol divinyl ether or diethylene glycol diallyl ether.
Claim 11
Dependent Claim
70 words
A packing material according to claim 6, wherein said totally porous, hydroxyl group-containing nonionic polymer is one obtained by suspension-polymerizing a monomer liquid containing 10% by weight or more, based on the total amount of monomer, of at least a dicarboxylic acid divinyl ester to obtain grains and subjecting the resulting grains to ester exchange reaction or saponification in such a solvent as will not dissolve or swell polyvinyl alcohol.
Claim 12
Dependent Claim
41 words
A packing material according to claim 6, wherein said polyfunctional substance is a member selected from the group consisting of an epihalohydrin, a compound having at least two epoxy groups, a compound having at least two aldehyde groups and mixtures thereof.
Claim 13
Dependent Claim
12 words
A packing material according to claim 11, wherein said epihalohydrin is epichlorohydrin.
Claim 14
Dependent Claim
39 words
A packing material according to claim 11, wherein said compound having at least two epoxy groups is a member selected from the group consisting of ethylene glycol diglycidyl ether, propylene glycol diglycidyl ether, trimethylolpropane triglycidyl ether and mixtures thereof.
Claim 15
Dependent Claim
30 words
A packing material according to claim 11, wherein said compound having at least two aldehyde groups is a member selected from the group consisting of glyoxal, glutaraldehyde and mixtures thereof.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-07-12 | 1986-01-11 | 1986-07-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-07-12 | 1990-01-11 | 1990-07-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-07-12 | 1994-01-11 | 1994-07-13 | $7700.00 | Window Closed / Lapsed |