US4337261A
Expired / Lapsed
US
⏱️ 0.0 years remaining
(1,2-Benzisoxazol)phenoxyacetic acids as diuretics
Assignee: Aventis Pharmaceuticals Inc
•
Filing: 1980-07-28
•
Granted: 1982-06-29
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Expires: 2000-07-28
Abstract
Abstract Novel (1,2-benzisoxazol)phenoxyacetic acids and related compounds, methods for preparing same and methods of treatment by administering compositions containing such a compound are described. These compounds are useful as diuretics.
Inventors
- 👤 Gregory M. Shutske
- 👤 Linda L. Setescak
- 👤 Richard C. Allen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 01:27
CPC Classifications
C; C07; C07D; C07D261/00; C07D261/20; A; A61; A61P; A61P7/00; A61P7/10; C07C; C07C45/00; C07C45/45; C07C45/46; C07C45/61; C07C45/67; C07C45/673; C07C49/00; C07C49/76; C07C49/84
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
47 words
A compound depicted by the formula ##STR10## in which R is Cl, CH 3 or Br; R 2 is Cl, Br or CH 3 ; R 1 is hydrogen or lower-alkyl; and X is hydrogen, halogen, loweralkyl, amino, acylamino or nitro; and a physiologically acceptable salt thereof.
Claim 2
Dependent Claim
47 words
A compound depicted by the formula ##STR10## in which R is Cl, CH 3 or Br; R 2 is Cl, Br or CH 3 ; R 1 is hydrogen or lower-alkyl; and X is hydrogen, halogen, loweralkyl, amino, acylamino or nitro; and a physiologically acceptable salt thereof.
Claim 3
Dependent Claim
16 words
The compound as defined in claim 1 wherein R and R 2 are CH 3 .
Claim 4
Dependent Claim
14 words
The compound as defined in claim 1 wherein R and R 2 are chlorine.
Claim 5
Dependent Claim
12 words
The compound as defined in claim 1 wherein R 1 is hydrogen.
Claim 6
Dependent Claim
11 words
The compound as defined in claim 1 which is ethyl 4-(1,2-benzisoxazol-3-yl)-2,3-dimethylphenoxyacetate.
Claim 7
Dependent Claim
15 words
The compound as defined in claim 1 which is 4-(1,2-benzisoxazol-3-yl)-2,3-dimethylphenoxyacetic acid or a salt thereof.
Claim 8
Dependent Claim
11 words
The compound as defined in claim 1 which is ethyl 4-(1,2-benzisoxazole-3-yl)-2,3-dichlorophenoxyacetate.
Claim 9
Dependent Claim
15 words
The compound as defined in claim 1 which is 4-(1,2-benzisoxazol-3-yl)-2,3-dichlorophenoxyacetic acid or a salt thereof.
Claim 10
Independent Claim
66 words
A method of producing diuresis which comprises administering to a patient in need of diuresis a diuretically effective amount of a compound depicted by the formula ##STR11## in which R is CI, CH 3 or Br; R 2 is Cl, CH 3 or Br; R 1 is hydrogen or lower-alkyl; and X is hydrogen, halogen, loweralkyl, amino, acylamino or nitro; and a physiologically acceptable salt thereof.
Claim 11
Independent Claim
66 words
A method of producing diuresis which comprises administering to a patient in need of diuresis a diuretically effective amount of a compound depicted by the formula ##STR11## in which R is CI, CH 3 or Br; R 2 is Cl, CH 3 or Br; R 1 is hydrogen or lower-alkyl; and X is hydrogen, halogen, loweralkyl, amino, acylamino or nitro; and a physiologically acceptable salt thereof.
Claim 12
Dependent Claim
20 words
The method as defined in claim 9 where said compound has R and R 2 which are CH 3 .
Claim 13
Dependent Claim
18 words
The method as defined in claim 9 where said compound has R and R 2 which are chlorine.
Claim 14
Dependent Claim
16 words
The method as defined in claim 9 where said compound has R 1 which is hydrogen.
Claim 15
Dependent Claim
13 words
The method as defined in claim 9 where said compound is ethyl 4-(1,2-benzisoxazol-3-yl)-2,3-dimethylphenoxyacetate.
Claim 16
Dependent Claim
17 words
The method as defined in claim 9 where said compound is 4-(1,2-benzisoxazol-2-yl)-2,3-dimethylphenoxyacetic acid or a salt thereof.
Claim 17
Dependent Claim
13 words
The method as defined in claim 9 where said compound is ethyl 4-(1,2-benzisoxazol-3-yl)-2,3-dichlorophenoxyacetate.
Claim 18
Dependent Claim
17 words
The method as defined in claim 9 where said compound is 4-(1,2-benzisoxazol-3-yl)-2,3-dichlorophenoxyacetic acid or a salt thereof.
Claim 19
Dependent Claim
56 words
A pharmaceutical composition comprising a pharmaceutically effective amount of a compound depicted by the formula ##STR12## in which R is Cl, Br or CH 3 ; R 2 is Cl, CH 3 or Br; R 1 is hydrogen or loweralkyl; and X is hydrogen, halogen, loweralkyl, amino, acylamino or nitro; and a physiologically acceptable salt thereof.
Claim 20
Dependent Claim
56 words
A pharmaceutical composition comprising a pharmaceutically effective amount of a compound depicted by the formula ##STR12## in which R is Cl, Br or CH 3 ; R 2 is Cl, CH 3 or Br; R 1 is hydrogen or loweralkyl; and X is hydrogen, halogen, loweralkyl, amino, acylamino or nitro; and a physiologically acceptable salt thereof.
Claim 21
Dependent Claim
20 words
The pharmaceutical composition defined in claim 17 wherein the R and R 2 of said compound are CH 3 .
Claim 22
Dependent Claim
18 words
The pharmaceutical composition defined in claim 17 wherein the R and R 2 of said compound are chlorine.
Claim 23
Dependent Claim
16 words
The pharmaceutical composition defined in claim 17 wherein the R 1 of said compound is hydrogen.
Claim 24
Dependent Claim
11 words
The pharmaceutical composition defined in claim 17 which comprises ethyl 4-(1,2-benzisoxazol-3-yl)-2,3-dimethylphenoxyacetate.
Claim 25
Dependent Claim
15 words
The pharmaceutical composition defined in claim 17 which comprises 4-(1,2-benzisoxazol-3-yl)-2,3-dimethylphenoxyacetic acid or a salt thereof.
Claim 26
Dependent Claim
11 words
The pharmaceutical composition defined in claim 17 which comprises ethyl 4-(1,2-benzisoxazol-3-yl)-2,3-dichlorophenoxyacetate.
Claim 27
Dependent Claim
15 words
The pharmaceutical composition defined in claim 17 which comprises 4-(1,2-benzisoxazol-3-yl)-2,3-dichlorophenoxyacetic acid or a salt thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-06-28 | 1985-12-28 | 1986-06-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-06-28 | 1989-12-28 | 1990-06-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-06-28 | 1993-12-28 | 1994-06-29 | $7700.00 | Window Closed / Lapsed |