US4337222A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hemoglobin concentration determining article
Assignee: Fujifilm Holdings Corp
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Filing: 1981-01-07
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Granted: 1982-06-29
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Expires: 2001-01-07
Abstract
Abstract A hemoglobin concentration-determining article comprising a water-impermeable support having integrally provided thereon, in sequence, a hydrophilic binder layer and a porous spreading layer which has a hydrophilic surface and in which the surface of the internal voids or the interior is hydrophilic and water-insoluble, said porous spreading layer being constituted so that an aqueous sample applied thereto can be spread and incorporated therein in a substantially definite volume per unit area.
Inventors
- 👤 Masao Kitajima
- 👤 Fuminori Arai
- 👤 Asaji Kondo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:46
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/52; G01N33/525
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
111 words
A hemoglobin concentration-determining article comprising a water-impermeable support having integrally provided thereon, in sequence, a hydrophilic binder layer and a porous spreading layer which has a hydrophilic surface and in which the surface of the internal voids or the interior is hydrophilic and water-insoluble, said porous spreading layer being constituted so that an aqueous sample applied thereto can be spread and incorporated therein in a substantially definite volume per unit area, wherein the porous spreading layer comprises a non-fibrous porous material having a mean pore diameter of about 2.5 μm to about 500 μm or a fibrous porous material having a yarn number count of from about 40 to about 100.
Claim 2
Dependent Claim
111 words
A hemoglobin concentration-determining article comprising a water-impermeable support having integrally provided thereon, in sequence, a hydrophilic binder layer and a porous spreading layer which has a hydrophilic surface and in which the surface of the internal voids or the interior is hydrophilic and water-insoluble, said porous spreading layer being constituted so that an aqueous sample applied thereto can be spread and incorporated therein in a substantially definite volume per unit area, wherein the porous spreading layer comprises a non-fibrous porous material having a mean pore diameter of about 2.5 μm to about 500 μm or a fibrous porous material having a yarn number count of from about 40 to about 100.
Claim 3
Dependent Claim
18 words
The hemoglobin concentration-determining article as claimed in claim 1, wherein the non-fibrous porous material comprises a porous membrane.
Claim 4
Dependent Claim
21 words
The hemoglobin concentration-determining article as claimed in claim 2, wherein said fibrous porous material is glass fiber, a fabric or paper.
Claim 5
Dependent Claim
17 words
The hemoglobin concentration-determining article as claimed in claim 1, wherein said water-impermeable support is transparent and planar.
Claim 6
Dependent Claim
24 words
The hemoglobin concentration-determining article as claimed in claim 1, wherein said water-impermeable support is a planar support of glass or a synthetic resin film.
Claim 7
Dependent Claim
62 words
The hemoglobin concentration-determining article as claimed in claim 1, wherein said porous spreading layer contains one or more agents to stabilize the hue of hemoglobin or erythrocyte membrane-modifying agents selected from the group consisting of a pH buffer, an anticoagulant, an antihemolytic agent, an antioxidant, an oxidizing agent, a dye, a pigment, an inorganic salt, an aldehyde, an isocyanate and hydrogen peroxide.
Claim 8
Dependent Claim
34 words
The hemoglobin concentration-determining article as claimed in claim 1, wherein said hydrophilic binder layer is formed of a member selected from the group consisting of gelatin, agarose, dextran, polyvinyl alcohol, polyacrylamide and polyacrylic acid.
Claim 9
Dependent Claim
51 words
The hemoglobin concentration-determining article as claimed in claim 1, wherein said hydrophilic binder layer contains one or more additives selected from the group consisting of nonionic, cationic or anionic surfactants, plasticizers, inorganic salts, organic acid salts, pH buffers, pigments, dyes, solid fine particulate fibers, oxidizing agents, reducing agents, acids and alkalis.
Claim 10
Dependent Claim
33 words
The hemoglobin concentration-determining article as claimed in claim 1, wherein said hemoglobin concentration-determining article is free of any agents which elute therefrom upon contact with the aqueous sample to permit hemoglobin concentration determination.
Claim 11
Dependent Claim
29 words
The hemoglobin concentration-determining article as claimed in claim 6, wherein said porous spreading layer consists essentially of said non-fibrous porous material or said fibrous porous material and said additives.
Claim 12
Dependent Claim
46 words
The hemoglobin concentration-determining article as claimed in claim 1, wherein said non-fibrous porous material has a mean pore diameter of from about 3 μm to about 100 μm and wherein said fibrous porous material has a yarn number count of from about 60 to about 80.
References Cited (Backward Citations)
US4250257A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-06-28 | 1985-12-28 | 1986-06-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-06-28 | 1989-12-28 | 1990-06-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-06-28 | 1993-12-28 | 1994-06-29 | $7700.00 | Window Closed / Lapsed |