US4336394A
Expired / Lapsed
US
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Cyano-ureas, cyano-thioureas and their preparation methods
Assignee: RECHERCHES ET DE SNYTHESES ORGAIQUES SA Ste
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Filing: 1980-03-14
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Granted: 1982-06-22
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Expires: 2000-03-14
Abstract
Abstract The invention relates to cyano-urea and cyano-thiourea derivatives characterized by structures of formulas (a),(b),(c) and (d): ##STR1## in which R is 2-mercapto-ethyl radical or 2-((4-methyl-5-imidazolyl) thiomethyl) ethyl radical. The invention relates to the manufacture of cyano-ureas and cyano-thioureas. The compounds of invention: N-2-((4-methyl-5-imidazolyl)thiomethyl) ethyl-N'-imino-cyano-urea,N-2-((4-methyl-5-imidazolyl)thiomethyl) ethyl N'-imino-cyano-thiourea, as well as their carbonyl and thio-carbonyl tautomers are histamine antagonists in the H 2 receptors which inhibit the secretion of gastric acid. They can be used therapeutically for the treatment of gastric and duodenal ulcers.
Inventors
- 👤 Pierre J. Baudet
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 16:12
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/64; C07D231/00; C07D231/02; C07D231/10; C07D231/12; C07D233/56; C07D249/00; C07D249/02; C07D249/08
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
19 words
Cyano-ureas having the formula: ##STR5## characterized by the imino-nitrile tautomer structure, wherein R is a 2-((4-methyl-5imidazolyl) methylthio ethyl radical.
Claim 2
Dependent Claim
19 words
Cyano-ureas having the formula: ##STR5## characterized by the imino-nitrile tautomer structure, wherein R is a 2-((4-methyl-5imidazolyl) methylthio ethyl radical.
Claim 3
Dependent Claim
19 words
Cyano-ureas having the formula: ##STR6## characterized by the amino-nitrile tautomer structure, wherein R is a 2-((4-methyl-5-imidazoly) myethylthio) ethyl radical.
Claim 4
Dependent Claim
19 words
Cyano-ureas having the formula: ##STR6## characterized by the amino-nitrile tautomer structure, wherein R is a 2-((4-methyl-5-imidazoly) myethylthio) ethyl radical.
Claim 5
Dependent Claim
19 words
Cryano-thioureas having the formula: ##STR7## characterized by the imino-nitrile tautomer structure, wherein R is a 2-((4-methyl-5-imidazoly) methylthio) ethyl radical.
Claim 6
Dependent Claim
19 words
Cryano-thioureas having the formula: ##STR7## characterized by the imino-nitrile tautomer structure, wherein R is a 2-((4-methyl-5-imidazoly) methylthio) ethyl radical.
References Cited (Backward Citations)
US4192879A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-06-21 | 1985-12-21 | 1986-06-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-06-21 | 1989-12-21 | 1990-06-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-06-21 | 1993-12-21 | 1994-06-22 | $7700.00 | Window Closed / Lapsed |