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US4334880A
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Analytical device having semiconductive polyacetylene element associated with analyte-binding substance
Assignee: Strategic Diagnostics Inc
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Filing: 1980-10-20
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Granted: 1982-06-15
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Expires: 2000-10-20
Abstract
Abstract A method, sensor and semiconductor device for determining the concentration of an analyte in a medium. The device features an element constructed of polyacetylene associated with a binding substance having specific affinity for the analyte.
Inventors
- 👤 Mark K. Malmros
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 14:33
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/536; G01N33/542; G01N27/00; G01N27/26; G01N27/403; G01N27/414; G01N27/4145; G01N33/543; G01N33/54366; G01N33/54373; G01N33/5438
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
80 words
A device for determining the concentration of an analyte in a medium, comprising: (a) sensor means including an element whose resistance varies in response to the presence of an analyte, where said element includes a binding substance which has specific affinity for the analyte, (b) means including spaced-apart electrodes contacting the element for measuring the resistance of the element, (c) means for bringing the medium in contact with the sensor, wherein the improvement comprises: said element being constructed of polyacetylene.
Claim 2
Independent Claim
80 words
A device for determining the concentration of an analyte in a medium, comprising: (a) sensor means including an element whose resistance varies in response to the presence of an analyte, where said element includes a binding substance which has specific affinity for the analyte, (b) means including spaced-apart electrodes contacting the element for measuring the resistance of the element, (c) means for bringing the medium in contact with the sensor, wherein the improvement comprises: said element being constructed of polyacetylene.
Claim 3
Dependent Claim
11 words
The device as in claim 1 where there are two electrodes.
Claim 4
Dependent Claim
11 words
The device as in claim 1 where there are three electrodes.
Claim 5
Dependent Claim
47 words
A device as in claim 1, 2 or 3 where the specific binding substance is selected from the group consisting of an antibody, an antigen, an enzyme, an enzyme substrate, an enzyme substrate analog, an agglutinin or lectin, an enzyme cofactor, an enzyme inhibitor and a hormone.
Claim 6
Dependent Claim
55 words
A variable resistance sensor for determination of an analyte in a medium comprising: an insulating structure, element means having an active part composed of polyacetylene mounted on said structure for exposure to the medium and electrodes positioned to contact the element, and where the polyacetylene element means includes a specific binding substance for the analyte.
Claim 7
Dependent Claim
55 words
A variable resistance sensor for determination of an analyte in a medium comprising: an insulating structure, element means having an active part composed of polyacetylene mounted on said structure for exposure to the medium and electrodes positioned to contact the element, and where the polyacetylene element means includes a specific binding substance for the analyte.
Claim 8
Dependent Claim
11 words
The sensor as in claim 5 where there are two electrodes.
Claim 9
Dependent Claim
11 words
The sensor as in claim 5 where there are three electrodes.
Claim 10
Dependent Claim
38 words
The sensor as in claim 5, 6 or 7, where the specific binding substance is selected from the group consisting of antibodies, antigens, enzymes, enzyme substrates, analoges of enzyme substrates, agglutinins, lectins, enzyme cofactors, enzyme inhibitors and hormones.
Claim 11
Independent Claim
52 words
A method of identifying the type and quantity of an analyte in a medium comprising the steps of: (a) preparing an element of polyacetylene (b) treating the element with a specific binding substance, (c) exposing the element to the medium, (d) measuring the change in an electrical characteristic of the treated element.
Claim 12
Independent Claim
52 words
A method of identifying the type and quantity of an analyte in a medium comprising the steps of: (a) preparing an element of polyacetylene (b) treating the element with a specific binding substance, (c) exposing the element to the medium, (d) measuring the change in an electrical characteristic of the treated element.
Claim 13
Dependent Claim
26 words
The method of claim 9 including the steps of applying at least two electrodes to contact the element and measuring the electrical changes between the electrodes.
Claim 14
Dependent Claim
16 words
The method of claim 10 including the step of applying three electrodes to contact the element.
Claim 15
Dependent Claim
47 words
The method as in claim 9, 10 or 11, where the specific binding substance is selected from the group consisting of an antibody, an antigen, an enzyme, an enzyme substrate, an enzyme substrate analog, an agglutinin or lectin, an enzyme cofactor, an enzyme inhibitor and a hormone.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-06-14 | 1985-12-14 | 1986-06-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-06-14 | 1989-12-14 | 1990-06-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-06-14 | 1993-12-14 | 1994-06-15 | $7700.00 | Window Closed / Lapsed |