US4334526A
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US
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Method for administering a dissociative, unconscious type of anesthesia
Assignee: Individual
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Filing: 1980-12-22
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Granted: 1982-06-15
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Expires: 2000-12-22
Abstract
Abstract A method and system of administering a dissociative unconscious type of anesthesia are disclosed. The method and system are designed for use in office surgical units and outpatient facilities. Administration by a nurse or a physician without anesthesia training can be done with minimum danger to the patient and minimum recovery time. The method and system utilizes the intravenous titration method of administration of a combination of drugs by which the patient is placed in a dissociative, unconscious state and maintained in this state until completion of the procedure, at which time the effect of the drugs is reversed by other drugs as desired. The intravenous anesthesia is supported by infiltration of a local anesthetic, such as Xylocaine. The combination of drugs include the basal hypnotic diazepam (Valium), a dissociated unconsciousness and general analgesia phencyclidine (Ketamine) and the narcotic analgesic Nisentil. The effects of the anesthetic can be reversed by the person administering the anesthesia as soon as their desired purpose has been accomplished.
Inventors
- 👤 Edward N. Hamacher
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 10:33
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/55
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
146 words
A method of inducing a dissociative type of sedation in a patient for surgical procedures which is safe and capable of being used in an office and being administered by a nurse or physician without anesthesia training, the process allowing a minimal recovery period for the patient, comprising: administering intravenously a therapeutic dose of an anticholinergic agent to stabilize heart action, reduce and prevent laryngeal spasm, administering intravenously a therapeutic dose of a basal hypnotic sufficient to relieve patient stress reaction, and administering intravenously a dissociative and general analgesic drug in an effective dose to induce a state of dissociation in the patient so that the patient is free of pain during infiltration of a local anesthetic into the skin and subcutaneous tissue of the patient where the surgical procedure is to take place and can be given and respond to commands during the surgical procedure.
Claim 2
Independent Claim
146 words
A method of inducing a dissociative type of sedation in a patient for surgical procedures which is safe and capable of being used in an office and being administered by a nurse or physician without anesthesia training, the process allowing a minimal recovery period for the patient, comprising: administering intravenously a therapeutic dose of an anticholinergic agent to stabilize heart action, reduce and prevent laryngeal spasm, administering intravenously a therapeutic dose of a basal hypnotic sufficient to relieve patient stress reaction, and administering intravenously a dissociative and general analgesic drug in an effective dose to induce a state of dissociation in the patient so that the patient is free of pain during infiltration of a local anesthetic into the skin and subcutaneous tissue of the patient where the surgical procedure is to take place and can be given and respond to commands during the surgical procedure.
Claim 3
Dependent Claim
21 words
The method of claim 1, including administering intravenously a therapeutic dosage of an analgesic with the dissociative and general analgesic drug.
Claim 4
Dependent Claim
56 words
The method of claim 2 wherein the basal hypnotic is diazepam administered in 1 to 3 mg. increments per minute up to 10 mg., wherein the dissociative and general analgesic drug is a phencyclidine derivative titrated intravenously at a dosage of from 15 mg. to 50 mg. at the rate of 1 mg. to 3 mg./minute.
Claim 5
Dependent Claim
11 words
The method of claim 3 wherein the phencyclidine derivative is Ketamine.
Claim 6
Dependent Claim
27 words
The method of claim 3 wherein the analgesic is alphaprodine administered intravenously in a dosage of 10 to 40 mg. at the rate of about 1 mg./minute.
Claim 7
Dependent Claim
15 words
The method of claim 3 wherein the anticholinergic agent is atropine or an atropine derivative.
Claim 8
Dependent Claim
25 words
The method of claim 3, including potentiating the sedative effects of the phencyclidine derivative by intravenous administration of 6 to 25 mg. promethazine hydrochloride (Phenergan).
Claim 9
Dependent Claim
58 words
The method of claim 1, including reversing the effect of the intravenous anesthesia after completion of the surgical procedure or as necessary for respiratory distress or to relieve confusion or excessive drowsiness of the patient by intravenous administration of a therapeutic amount of an anticholinesterase agent capable of reversing the effect of the basal hypnotic on the patient.
Claim 10
Dependent Claim
28 words
The method of claim 1 wherein a therapeutic amount of Seconal is administered orally to the patient together with Combid prior to intravenous administration of the other drugs.
Claim 11
Dependent Claim
38 words
The method of claim 1, including supporting the intravenous anesthesia by infiltration of a local anesthetic into the skin and subcutaneous tissues of the patient where the surgical procedure is to take place after analgesia of the patient.
Claim 12
Dependent Claim
22 words
The method of claim 10 wherein the local anesthetic is Xylocaine administered as soon as the phencyclidine takes effect in the patient.
Claim 13
Dependent Claim
11 words
The method of claim 1 wherein the basal hypnotic is Inapsine.
Claim 14
Dependent Claim
18 words
The method of claim 12 wherein Inapsine is administered intravenously at a dosage of 1/2 to 1 cc.
Claim 15
Dependent Claim
20 words
The method of claim 1, including the intravenous administration of from 0.2 to 0.6 mg. Narcan after the surgical procedure.
Claim 16
Independent Claim
119 words
A method of producing a dissociative type of sedation for surgery, comprising: administering intravenously a therapeutic dose of an anticholinergic agent to stabilize heart action, reduce and prevent laryngeal spasm, administering intravenously a therapeutic dose of the basal hypnotic diazepam to relieve patient stress reaction, and administering intravenously a dissociative and general analgesic phencyclidine derivative and the analgesic alphaprodine together in therapeutic amounts sufficient to induce a state of dissociation in the patient so that the patient to be is free of pain during the infiltration of a local anesthetic into the skin and subcutaneous tissue of the patient where the surgical procedure is to take place and can be given and respond to commands during the surgical procedure.
Claim 17
Independent Claim
119 words
A method of producing a dissociative type of sedation for surgery, comprising: administering intravenously a therapeutic dose of an anticholinergic agent to stabilize heart action, reduce and prevent laryngeal spasm, administering intravenously a therapeutic dose of the basal hypnotic diazepam to relieve patient stress reaction, and administering intravenously a dissociative and general analgesic phencyclidine derivative and the analgesic alphaprodine together in therapeutic amounts sufficient to induce a state of dissociation in the patient so that the patient to be is free of pain during the infiltration of a local anesthetic into the skin and subcutaneous tissue of the patient where the surgical procedure is to take place and can be given and respond to commands during the surgical procedure.
Claim 18
Dependent Claim
71 words
The method of claim 15 wherein the diazepam is administered in a dosage up to 10 mg. in 1 to 3 mg. increments, the phencyclidine derivative is Ketamine administered by titration in a dosage of from 25 to 50 mg. at the rate of 1 to 3 mg./minute, and the alphaprodine is administered by titration at a dosage of from 10 to 40 mg. at a rate of about 1 mg./minute.
Claim 19
Dependent Claim
42 words
The method of claim 16, including supporting the intravenous anesthesia by infiltration of the local anesthetic Xylocaine into the skin and subcutaneous tissues of the patient where the surgical procedure is to take place after the Ketamine takes effect on the patient.
References Cited (Backward Citations)
US4246894A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-06-14 | 1985-12-14 | 1986-06-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-06-14 | 1989-12-14 | 1990-06-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-06-14 | 1993-12-14 | 1994-06-15 | $7700.00 | Window Closed / Lapsed |