Comprehensive pulmonary measurement technique

Claim 1

An apparatus for the comprehensive measurement of pulmonary functions comprising: a source of gas which includes no nitrogen; a closed pulmonary measurement system including an input spirometer coupled to said source of gas for supplying a measured quantity of said gas excluding nitrogen from said source to a subject; means for collecting gas exhaled by the subject; means for supplying alternating pressure signals to the mouth of a subject; means for measuring the flow of air exhaled by the subject; means for continuously measuring the nitrogen content of the exhaled air; means for determining the resistance of the lungs to both steady state and alternating air flow during various portions of a breathing cycle; and means for recording and correlating all of said measured and determined values.

Claim 2

An apparatus for the comprehensive measurement of pulmonary functions comprising: a source of gas which includes no nitrogen; a closed pulmonary measurement system including an input spirometer coupled to said source of gas for supplying a measured quantity of said gas excluding nitrogen from said source to a subject; means for collecting gas exhaled by the subject; means for supplying alternating pressure signals to the mouth of a subject; means for measuring the flow of air exhaled by the subject; means for continuously measuring the nitrogen content of the exhaled air; means for determining the resistance of the lungs to both steady state and alternating air flow during various portions of a breathing cycle; and means for recording and correlating all of said measured and determined values.

Claim 5

An apparatus for the comprehensive measurement of pulmonary functions comprising: means for supplying alternating pressure signals to the mouth of a subject; means for measuring the flow of air exhaled by the subject; means for determining the resistance of the lungs to both steady state and alternating air flow during various portions of a breathing cycle; an esophageal balloon and transducer system having a predetermined frequency response for supplying signals representing the pressure across the lungs; compensation circuit means connected to receive said signals representing the pressure across said lungs, and for correcting the frequency variations of said signals within the frequency range of interest and extending above the normal frequency of operation of said means for supplying alternating pressure; and means for recording information representing the measured air flow and the corrected signals from said compensation circuit means.

Claim 6

An apparatus for the comprehensive measurement of pulmonary functions comprising: means for supplying alternating pressure signals to the mouth of a subject; means for measuring the flow of air exhaled by the subject; means for determining the resistance of the lungs to both steady state and alternating air flow during various portions of a breathing cycle; an esophageal balloon and transducer system having a predetermined frequency response for supplying signals representing the pressure across the lungs; compensation circuit means connected to receive said signals representing the pressure across said lungs, and for correcting the frequency variations of said signals within the frequency range of interest and extending above the normal frequency of operation of said means for supplying alternating pressure; and means for recording information representing the measured air flow and the corrected signals from said compensation circuit means.

Claim 8

An apparatus for the comprehensive measurement of pulmonary functions comprising: means for generating alternating pressure signals, said means having a substantial output area; means including a tapered air channel impedance matching means for coupling the substantial output area of said alternating pressure generating means to the mouth of a subject; direct duct means bypassing said alternating pressure generating means for receiving forceful exhalations from said subject while the subject is receiving the alternating pressure signals; means for measuring the flow of air exhaled by the subject; means for recording the measured flow of air; and means for determining the resistance of the lungs to both steady state and alternating air flow during various portions of a breathing cycle.

Claim 9

An apparatus for the comprehensive measurement of pulmonary functions comprising: means for generating alternating pressure signals, said means having a substantial output area; means including a tapered air channel impedance matching means for coupling the substantial output area of said alternating pressure generating means to the mouth of a subject; direct duct means bypassing said alternating pressure generating means for receiving forceful exhalations from said subject while the subject is receiving the alternating pressure signals; means for measuring the flow of air exhaled by the subject; means for recording the measured flow of air; and means for determining the resistance of the lungs to both steady state and alternating air flow during various portions of a breathing cycle.

Claim 10

A method of measuring pulmonary functions including the steps of: supplying alternating pressure signals to the mouth of a subject; measuring the flow rate of an exhalation from said subject; measuring the resistance of the lungs to the alternating pressure applied to the mouth of the subject at a plurality of discrete expiratory volumes throughout said exhalation; measuring the resistance of the lungs to the steady or unidirectional flow of air from the subject at a plurality of discrete expiratory volumes throughout said exhalation; and comparing the measured alternating pressure resistance with the measured resistance to steady or unidirectional flow at said plurality of discrete volumes throughout said exhalation.

Claim 11

A method of measuring pulmonary functions including the steps of: supplying alternating pressure signals to the mouth of a subject; measuring the flow rate of an exhalation from said subject; measuring the resistance of the lungs to the alternating pressure applied to the mouth of the subject at a plurality of discrete expiratory volumes throughout said exhalation; measuring the resistance of the lungs to the steady or unidirectional flow of air from the subject at a plurality of discrete expiratory volumes throughout said exhalation; and comparing the measured alternating pressure resistance with the measured resistance to steady or unidirectional flow at said plurality of discrete volumes throughout said exhalation.

Claim 15

A method for the comprehensive measurement of the pulmonary functions of a subject including the steps of: supplying a measured amount of nitrogen-free gas to a subject for inhalation from a spirometer; measuring the flow of gas inhaled by the subject; supplying alternating pressure signals to the mouth of a subject; measuring the flow rate of an expiration from said subject; measuring the pressure across the lungs of the subject; measuring the nitrogen content in exhalations from the subject; collecting the gases exhaled by the subject; continuously recording data from all of the measurements identified hereinabove; determining the resistance of the lungs to the alternating pressure applied to the mouth of the subject at a plurality of different expiratory volumes throughout said expiration; determining the resistance of the lungs to the steady or unidirectional flow or air from the subject at a plurality of different expiratory volumes throughout said exhalation; and determining the vital capacity of the lungs of the subject from the inhalation flow measurements; and determining the residual volume of the lungs from the nitrogen measurements; and recording the determined values.

Claim 16

A method for the comprehensive measurement of the pulmonary functions of a subject including the steps of: supplying a measured amount of nitrogen-free gas to a subject for inhalation from a spirometer; measuring the flow of gas inhaled by the subject; supplying alternating pressure signals to the mouth of a subject; measuring the flow rate of an expiration from said subject; measuring the pressure across the lungs of the subject; measuring the nitrogen content in exhalations from the subject; collecting the gases exhaled by the subject; continuously recording data from all of the measurements identified hereinabove; determining the resistance of the lungs to the alternating pressure applied to the mouth of the subject at a plurality of different expiratory volumes throughout said expiration; determining the resistance of the lungs to the steady or unidirectional flow or air from the subject at a plurality of different expiratory volumes throughout said exhalation; and determining the vital capacity of the lungs of the subject from the inhalation flow measurements; and determining the residual volume of the lungs from the nitrogen measurements; and recording the determined values.

Claim 20

A method for the comprehensive measurement of the respiratory functions of a subject including the steps of: supplying a measured amount of nitrogen-free gas to a subject for inhalation from a spirometer; measuring the flow of gas inhaled by the subject; supplying alternating pressure signals to the mouth of a subject; measuring the flow rate of an expiration from said subject; measuring the pressure at the mouth of the subject; measuring the nitrogen content in exhalations from the subject; collecting the gases exhaled by the subject; continuously recording data from all of the measurements identified hereinabove; determining the respiratory resistance to the alternating pressure applied to the mouth of the subject at a plurality of different expiratory volumes throughout said expiration; determining the respiratory resistance to the steady or unidirectional flow of air from the subject at a plurality of different expiratory volumes throughout said exhalation; determining the vital capacity of the lungs of the subject from the inhalation flow measurements; and determining the residual volume of the lungs from the nitrogen measurements.

Claim 21

A method for the comprehensive measurement of the respiratory functions of a subject including the steps of: supplying a measured amount of nitrogen-free gas to a subject for inhalation from a spirometer; measuring the flow of gas inhaled by the subject; supplying alternating pressure signals to the mouth of a subject; measuring the flow rate of an expiration from said subject; measuring the pressure at the mouth of the subject; measuring the nitrogen content in exhalations from the subject; collecting the gases exhaled by the subject; continuously recording data from all of the measurements identified hereinabove; determining the respiratory resistance to the alternating pressure applied to the mouth of the subject at a plurality of different expiratory volumes throughout said expiration; determining the respiratory resistance to the steady or unidirectional flow of air from the subject at a plurality of different expiratory volumes throughout said exhalation; determining the vital capacity of the lungs of the subject from the inhalation flow measurements; and determining the residual volume of the lungs from the nitrogen measurements.

Claim 22

A method of measuring respiratory functions including the steps of: supplying alternating pressure signals to the mouth of a subject; measuring the flow rate of an exhalation from said subject; measuring the resistance to the alternating pressure applied to the mouth of the subject at a plurality of discrete expiratory volumes throughout said exhalation; measuring the resistance to the steady or unidirectional flow of air from the subject at a plurality of discrete expiratory volumes throughout said exhalation; and comparing the measured alternating pressure resistance with the measured resistance to steady or unidirectional flow at said plurality of discrete volumes throughout said exhalation.

Claim 23

A method of measuring respiratory functions including the steps of: supplying alternating pressure signals to the mouth of a subject; measuring the flow rate of an exhalation from said subject; measuring the resistance to the alternating pressure applied to the mouth of the subject at a plurality of discrete expiratory volumes throughout said exhalation; measuring the resistance to the steady or unidirectional flow of air from the subject at a plurality of discrete expiratory volumes throughout said exhalation; and comparing the measured alternating pressure resistance with the measured resistance to steady or unidirectional flow at said plurality of discrete volumes throughout said exhalation.

Claim 24

An apparatus for the comprehensive measurement of pulmonary functions comprising: a source of gas containing no nitrogen; a closed pulmonary measurement system including an input spirometer coupled to said source of gas, for supplying a measured quantity of gas excluding nitrogen from said source to a subject; means for collecting gas exhaled by the subject; means including a low frequency loud speaker for supplying alternating pressure signals to the mouth of a subject; means for measuring the flow of air inhaled by the subject; means for measuring the flow of air exhaled by the subject; tapered air channel impedance matching means for coupling said speaker to the mouth of the subject; direct duct means bypassing said speaker for receiving forceful exhalation from said subject while the subject is receiving alternating pressure signals and for directing air from said forceful exhalations to said collecting means; an esophageal balloon and transducer means having a predetermined frequency response for supplying signals to said apparatus representing the pressure across the lungs; compensation circuit means connected to receive said signals representing the pressure across said lungs, and for correcting the frequency variations of said signals within the frequency range of interest and extending above the normal frequency of operation of said low frequency loud speaker; means for continuously detecting the pressure at the mouth of the subject; means for continuously monitoring the amount of nitrogen in the exhaled air; means for recording the measured values of (1) the input flow of gas to the subject, (2) the output flow of gas from the subject, (3) the varying pressure at the mouth of the subject, (4) the compensated pressure across the lungs derived from the esophageal balloon and transducer means, and (5) the nitrogen content of the exhalations; means for determining the resistance of the lungs to alternating pressure signals at a number of discrete points in an exhalation cycle; and means for determining the resistance of the lungs to steady gas flow at a number of discrete points in the same exhalation cycle.

Claim 25

An apparatus for the comprehensive measurement of pulmonary functions comprising: a source of gas containing no nitrogen; a closed pulmonary measurement system including an input spirometer coupled to said source of gas, for supplying a measured quantity of gas excluding nitrogen from said source to a subject; means for collecting gas exhaled by the subject; means including a low frequency loud speaker for supplying alternating pressure signals to the mouth of a subject; means for measuring the flow of air inhaled by the subject; means for measuring the flow of air exhaled by the subject; tapered air channel impedance matching means for coupling said speaker to the mouth of the subject; direct duct means bypassing said speaker for receiving forceful exhalation from said subject while the subject is receiving alternating pressure signals and for directing air from said forceful exhalations to said collecting means; an esophageal balloon and transducer means having a predetermined frequency response for supplying signals to said apparatus representing the pressure across the lungs; compensation circuit means connected to receive said signals representing the pressure across said lungs, and for correcting the frequency variations of said signals within the frequency range of interest and extending above the normal frequency of operation of said low frequency loud speaker; means for continuously detecting the pressure at the mouth of the subject; means for continuously monitoring the amount of nitrogen in the exhaled air; means for recording the measured values of (1) the input flow of gas to the subject, (2) the output flow of gas from the subject, (3) the varying pressure at the mouth of the subject, (4) the compensated pressure across the lungs derived from the esophageal balloon and transducer means, and (5) the nitrogen content of the exhalations; means for determining the resistance of the lungs to alternating pressure signals at a number of discrete points in an exhalation cycle; and means for determining the resistance of the lungs to steady gas flow at a number of discrete points in the same exhalation cycle.