Catalyst-containing stable polyurethane forming compositions which are non-cytotoxic when cured and separatory devices employing same

Claim 2

A two component polyurethane forming composition which is non-cytotoxic when cured consisting essentially of: (a) as a first component at least one NOC-terminated prepolymer; (b) as a second component of at least one polyol; and (c) an effective catalytic amount of a dialkyltin dicarboxylated compound having the formula: ##STR3## wherein: R1 and R2 are linear or branched alkyl groups having from about 8 about 18 carbon atoms per molecule; and R 3 and R 4 represent carboxylate groups derived from (a) one or more saturated or unsaturated, linear or barnched, aliphatic hydroxy-carboxylic acids having from about 2 to about 18 carbon atoms per molecule; (b) one or more saturated and unsaturated, linear or branched, aliphatic carboxylic acids having from about 14 to about 20 carbon atoms per molecule; and (c) mixtures of (a) and (b); and wherein said dialkyltin dicarboxylated compound is incorporated into said second component prior to curing and is stable therein.

Claim 3

The polyurethane forming composition of claim 1 wherein R 1 and R 2 are the same.

Claim 4

The polyurethane forming composition of claim 2 wherein (1) the NCO-terminated prepolymer is the reaction product of (a) at least one polyol selected from the group consisting of polyol esters, polyether polyols, and castor oil, and (b) at least one polyfunctional isocyanate selected from the group consisting of aromatic diisocyanates, aromatic triisocyanates, and aliphatic diisocyanates; (2) the polyol of the second component is selected from at least one member of the group consisting of polyether polyols, polyol esters, and castor oil; (3) the dialkyltin dicarboxylated catalyst is present in the second component in an amount of from about 0.01 to about 10%, by weight, based on the weight of the second component; and (4) the NCO-terminated prepolymer and the polyol is reacted at a weight ratio of from about 10:90 to about 90:10.

Claim 5

The polyurethane forming composition of claim 3 wherein the NCO-terminated prepolymer of the first component is selected from the group consisting of (1) the reaction product of polyoxypropylene glycol, castor oil and diphenylmethane 4,4'-diisocyanate, and (2) the reaction product of castor oil and 3-isocyanate methyl-3,5,5-trimethylcyclohexylisocyanate; wherein the second polyol component is selected from the group consisting of (1) mixtures of ethylene glycol monoricinoleate and polymerized castor oil and (2) polyoxypropylene adducts of trimethylolpropane; and wherein the dialkyltin dicarboxylated catalyst is present in the polyol component in an amount of from about 0.05 to about 5%, by weight, based on the weight of the polyol of the second component.

Claim 6

The polyurethane forming composition of claim 4 wherein the dialkyltin dicarboxylated catalyst is selected from the group consisting of dioctyltin diricinoleate, dioctyltin dioleate, didodecyltin diricinoleate and dioctyltin di-6-hydroxy caproate.

Claim 7

The polyurethane forming composition of claim 1 wherein the dialkyltin dicarboxylated compound is dioctyltin diricinoleate.

Claim 8

A stable polyol/catalyst composition which may be employed in a two component polyurethane forming composition which is non-cytotoxic when cured, when polyol/catalyst composition consists essentially of a mixture of: (a) at least one polyol; (b) an effective catalytic amount of a dialkyltin dicarboxylated compound having the formula: ##STR4## wherein: R1 and R2 are linear or branched alkyl groups having from about 8 about 18 carbon atoms per molecule; and R 3 and R 4 represent carboxylate groups derived from (a) one or more saturated or unsaturated, linear or barnched, aliphatic hydroxy-carboxylic acids having from about 2 to about 18 carbon atoms per molecule; (b) one or more saturated and unsaturated, linear or branched, aliphatic carboxylic acids having from about 14 to about 20 carbon atoms per molecule; and (c) mixtures of (a) and (b).

Claim 9

A stable polyol/catalyst composition which may be employed in a two component polyurethane forming composition which is non-cytotoxic when cured, when polyol/catalyst composition consists essentially of a mixture of: (a) at least one polyol; (b) an effective catalytic amount of a dialkyltin dicarboxylated compound having the formula: ##STR4## wherein: R1 and R2 are linear or branched alkyl groups having from about 8 about 18 carbon atoms per molecule; and R 3 and R 4 represent carboxylate groups derived from (a) one or more saturated or unsaturated, linear or barnched, aliphatic hydroxy-carboxylic acids having from about 2 to about 18 carbon atoms per molecule; (b) one or more saturated and unsaturated, linear or branched, aliphatic carboxylic acids having from about 14 to about 20 carbon atoms per molecule; and (c) mixtures of (a) and (b).

Claim 10

The polyol/catalyst composition of claim 7 wherein R 1 and R 2 are the same.

Claim 11

The polyol/catalyst composition of claim 8 wherein the polyol is selected from at least one member of the group consisting of polyether polyols, polyol esters, and castor oil; and the dialkyltin dicarboxylated catalyst is present in the polyol in an amount of from about 0.01 to about 10%, by weight, based on the weight of the second component.

Claim 12

The polyol/catalyst composition of claim 9 wherein the polyol is selected from the group consisting of (1) mixtures of ethylene glycol monoricinoleate and polymerized caster oil and (2) polyoxypropylene adducts of trimethylolpropane and wherein the dialkyltin dicarboxylated catalyst is present in the polyol component in an amount of from about 0.05 to about 5%, by weight, based on the weight of the polyol of the second component.

Claim 13

The polyol/catalyst composition of claim 10 wherein the dialkyltin dicarboxylated catalyst is selected from the group consisting of dioctyltin diricinoleate, dioctyltin dioleate, didodecyltin diricinoleate and dioctyltin di-6-hydroxy caproate.

Claim 14

The polyol/catalyst composition of claim 7 wherein the dialkyltin dicarboxylated compound is dioctyltin diricinoleate.

Claim 15

A cured non-cytotoxic polyurethane composition consisting essentially of the reaction product of: (a) as a first component at least one NCO-terminated prepolymer; (b) as a second component comprises at least one polyol; and (c) an effective catalytic amount of a dialkyltin dicarboxylated compound having the formula: ##STR5## wherein: R 1 and R 2 represent linear or branched alkyl groups having less than about 18 carbon atoms per molecule; and R 3 and R 4 represent carboxylate groups derived from (a) one or more saturated or unsaturated, linear or branched, aliphatic hydroxy-carboxylic acids having from about 2 to about 18 carbon atoms per molecule; (b) one or more saturated or unsaturated, linear or branched, aliphatic carboxylic acids having from about 14 to about 20 carbon atoms per molecule; and (c) mixtures of (a) and (b); and wherein said dialkyltin dicarboxylated compound is incorporated into said second component prior to curing and is stable therein.

Claim 16

A cured non-cytotoxic polyurethane composition consisting essentially of the reaction product of: (a) as a first component at least one NCO-terminated prepolymer; (b) as a second component comprises at least one polyol; and (c) an effective catalytic amount of a dialkyltin dicarboxylated compound having the formula: ##STR5## wherein: R 1 and R 2 represent linear or branched alkyl groups having less than about 18 carbon atoms per molecule; and R 3 and R 4 represent carboxylate groups derived from (a) one or more saturated or unsaturated, linear or branched, aliphatic hydroxy-carboxylic acids having from about 2 to about 18 carbon atoms per molecule; (b) one or more saturated or unsaturated, linear or branched, aliphatic carboxylic acids having from about 14 to about 20 carbon atoms per molecule; and (c) mixtures of (a) and (b); and wherein said dialkyltin dicarboxylated compound is incorporated into said second component prior to curing and is stable therein.

Claim 17

In a process for preparing a separatory device wherein a portion of at least one separatory membrane is secured in a housing using a non-cytotoxic cured polyurethane composition provided by reacting a first component comprising at least one NCO-terminated prepolymer with a second component comprising at least one polyol, wherein the improvement comprises reacting said NCO-terminated prepolymer of the first component with said polyol of the second component in the presence of an effective catalytic amount of a catalyst consisting essentially of a dialkyltin dicarboxylated compound having the formula: ##STR6## wherein: R 1 and R 2 represent linear or branched alkyl groups having less than about 18 carbon atoms per molecule; and R 3 and R 4 represent carboxylate groups derived from (a) one or more saturated or unsaturated, linear or branched, aliphatic hydroxy-carboxylic acids having from about 2 to about 18 carbon atoms per molecule; (b) one or more saturated or unsaturated, linear or branched, aliphatic carboxylic acids having from about 14 to about 20 carbon atoms per molecule; and (c) mixtures of (a) and (b); and wherein said dialkyltin dicarboxylated compound is incorporated in said second component prior to curing and is stable therein.

Claim 18

In a process for preparing a separatory device wherein a portion of at least one separatory membrane is secured in a housing using a non-cytotoxic cured polyurethane composition provided by reacting a first component comprising at least one NCO-terminated prepolymer with a second component comprising at least one polyol, wherein the improvement comprises reacting said NCO-terminated prepolymer of the first component with said polyol of the second component in the presence of an effective catalytic amount of a catalyst consisting essentially of a dialkyltin dicarboxylated compound having the formula: ##STR6## wherein: R 1 and R 2 represent linear or branched alkyl groups having less than about 18 carbon atoms per molecule; and R 3 and R 4 represent carboxylate groups derived from (a) one or more saturated or unsaturated, linear or branched, aliphatic hydroxy-carboxylic acids having from about 2 to about 18 carbon atoms per molecule; (b) one or more saturated or unsaturated, linear or branched, aliphatic carboxylic acids having from about 14 to about 20 carbon atoms per molecule; and (c) mixtures of (a) and (b); and wherein said dialkyltin dicarboxylated compound is incorporated in said second component prior to curing and is stable therein.

Claim 19

In a separatory device wherein at least one separatory membrane is secured in a housing in a manner sufficient to perform the selected separatory function using a non-cytotoxic cured polyurethane composition provided by reacting a first component comprising an NCO-terminated prepolymer with a second component comprising at least one polyol, wherein the improvement comprises using as the non-cytotoxic polyurethane composition at least one of said NCO-terminated prepolymers of the first component reacted with at least one of said polyols of the second component in the presence of an effective catalytic amount of a catalyst consisting essentially of a dialkyltin dicarboxylated compound having the formula: ##STR7## wherein: R 1 and R 2 represent linear or branched alkyl groups having less than about 18 carbon atoms per molecule; and R 3 and R 4 represent carboxylate groups derived from (a) one or more saturated or unsaturated, linear or branched, aliphatic hydroxy-carboxylic acids having from about 2 to about 18 carbon atoms per molecule; (b) one or more saturated or unsaturated, linear or branched, aliphatic carboxylic acids having from about 14 to about 20 carbon atoms per molecule; and (c) mixtures of (a) and (b); and wherein said dialkyltin dicarboxylated compound is incorporated into said second component prior to curing and is stable therein.

Claim 20

In a separatory device wherein at least one separatory membrane is secured in a housing in a manner sufficient to perform the selected separatory function using a non-cytotoxic cured polyurethane composition provided by reacting a first component comprising an NCO-terminated prepolymer with a second component comprising at least one polyol, wherein the improvement comprises using as the non-cytotoxic polyurethane composition at least one of said NCO-terminated prepolymers of the first component reacted with at least one of said polyols of the second component in the presence of an effective catalytic amount of a catalyst consisting essentially of a dialkyltin dicarboxylated compound having the formula: ##STR7## wherein: R 1 and R 2 represent linear or branched alkyl groups having less than about 18 carbon atoms per molecule; and R 3 and R 4 represent carboxylate groups derived from (a) one or more saturated or unsaturated, linear or branched, aliphatic hydroxy-carboxylic acids having from about 2 to about 18 carbon atoms per molecule; (b) one or more saturated or unsaturated, linear or branched, aliphatic carboxylic acids having from about 14 to about 20 carbon atoms per molecule; and (c) mixtures of (a) and (b); and wherein said dialkyltin dicarboxylated compound is incorporated into said second component prior to curing and is stable therein.