US4331650A
Expired / Lapsed
US
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Identification of reagins in the blood serum of allergen sensitized vertebrates
Assignee: SCIENCE RESEARCH CENTER Inc A CORP OF TX
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Filing: 1980-07-18
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Granted: 1982-05-25
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Expires: 2000-07-18
Abstract
Abstract The disclosure is of an improved method for the in-vitro detection and identification of reagins in the blood serum of allergen sensitized vertebrates. The improvement comprises admixing the blood serum of the vertebrate with solid, porous carrier particles bearing surface adsorbed, known allergens. An agglutination reaction indicates the presence of reagins corresponding to the surface adsorbed allergen.
Inventors
- 👤 John H. Brewer
- 👤 Terry L. Foster
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:44
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/551; Y; Y10; Y10S; Y10S436/00; Y10S436/807; Y10S436/809
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
95 words
A reagent for identifying a given reagin in the blood serum of a vertebrate, which reagent comprises; a plurality of non-polar, porous carrier particles having adsorbed thereon a composition of the formula A X-Y wherein A represents a polar allergen, X is a hydrophilic, polar moiety and Y represents a hydrophobic, non-polar moiety, and where X and Y are chemically bound together, and the X-Y compound is complexed with the allergen such that the X moiety is oriented toward the polar allergen molecule and the Y moiety is oriented away from the polar allergen molecule.
Claim 2
Dependent Claim
95 words
A reagent for identifying a given reagin in the blood serum of a vertebrate, which reagent comprises; a plurality of non-polar, porous carrier particles having adsorbed thereon a composition of the formula A X-Y wherein A represents a polar allergen, X is a hydrophilic, polar moiety and Y represents a hydrophobic, non-polar moiety, and where X and Y are chemically bound together, and the X-Y compound is complexed with the allergen such that the X moiety is oriented toward the polar allergen molecule and the Y moiety is oriented away from the polar allergen molecule.
Claim 3
Dependent Claim
12 words
The reagent of claim 1 wherein the carrier particles are activated charcoal.
Claim 4
Dependent Claim
12 words
The reagent of claim 1 wherein the moiety X-Y is a phospholipid.
Claim 5
Dependent Claim
10 words
The reagent of claim 3 wherein the phospholipid is lecithin.
Claim 6
Dependent Claim
23 words
The reagent of claim 1 wherein the moiety X-Y is selected from the group consisting of a phospholipid a non-phospholipid and mixture thereof.
Claim 7
Dependent Claim
16 words
The reagent of claim 5 wherein the selection is of a mixture of lecithin and cholesterol.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-05-24 | 1985-11-23 | 1986-05-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-05-24 | 1989-11-23 | 1990-05-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-05-24 | 1993-11-23 | 1994-05-25 | $7700.00 | Window Closed / Lapsed |