US4329356A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Treatment of hypertension with fluoxetine and l-5-hydroxytryptophane
Assignee: Eli Lilly and Co
•
Filing: 1980-10-31
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Granted: 1982-05-11
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Expires: 2000-10-31
Abstract
Abstract Fluoxetine alone or a combination of fluoxetine and l-5-hydroxytryptophan, preferably also with a peripheral decarboxylase inhibitor, is administered to hypertensive mammals to lower blood pressure.
Inventors
- 👤 Donald R. Holland
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 08:42
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/40; A61K31/403; A61K31/404; A61K31/405
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
53 words
A method for lowering blood pressure in a hypertensive mammal in need of treatment which comprises the co-administration of hypotensively effective amounts of fluoxetine and l-5-hydroxytryptophane or pharmaceutically acceptable salts thereof, the amount of said combination administered being significantly effective to reduce the blood pressure of said hypertensive mammal, compared to each alone.
Claim 2
Independent Claim
53 words
A method for lowering blood pressure in a hypertensive mammal in need of treatment which comprises the co-administration of hypotensively effective amounts of fluoxetine and l-5-hydroxytryptophane or pharmaceutically acceptable salts thereof, the amount of said combination administered being significantly effective to reduce the blood pressure of said hypertensive mammal, compared to each alone.
Claim 3
Dependent Claim
13 words
A process according to claim 1 in which the drugs are administered orally.
Claim 4
Dependent Claim
15 words
A process according to claim 2 in which fluoxetine is administered as a hydrochloride salt.
Claim 5
Dependent Claim
21 words
A process according to claim 3 in which the fluoxetine hydrochloride daily dosage level is 0.5-2 mg./kg. of mammalian body weight.
Claim 6
Dependent Claim
21 words
A process according to claim 2 in which the l-5-tryptophane daily dose level is from 3-40 mg/kg of mammalian body weight.
Claim 7
Independent Claim
66 words
A method for lowering blood pressure in hypertensive mammals in need of treatment which comprises the co-administration of hypotensively-effective amounts of fluoxetine, and l-5-tryptophan or pharmaceutically acceptable salts thereof, the amount of said combination, compared to each alone, being significantly effective to reduce the blood pressure of said hypertensive mammals plus a peripheral decarboxylase inhibitor in an amount sufficient to prevent side effects attributable to serotonin.
Claim 8
Independent Claim
66 words
A method for lowering blood pressure in hypertensive mammals in need of treatment which comprises the co-administration of hypotensively-effective amounts of fluoxetine, and l-5-tryptophan or pharmaceutically acceptable salts thereof, the amount of said combination, compared to each alone, being significantly effective to reduce the blood pressure of said hypertensive mammals plus a peripheral decarboxylase inhibitor in an amount sufficient to prevent side effects attributable to serotonin.
Claim 9
Dependent Claim
13 words
A process according to claim 6 in which the drugs are administered orally.
Claim 10
Dependent Claim
15 words
A process according to claim 7 in which fluoxetine is administered as a hydrochloride salt.
Claim 11
Dependent Claim
14 words
A process according to claim 6 in which the peripheral decarboxylase inhibitor is carbidopa.
Claim 12
Dependent Claim
22 words
A process according to claim 8 in which the fluoxetine hydrochloride daily dose level is from 0.5-2.0 mg/kg of mammalian body weight.
Claim 13
Dependent Claim
21 words
A process according to claim 7 in which the l-5-tryptophan daily dose level is from 2-40 mg/kg of mammalian body weight.
Claim 14
Dependent Claim
21 words
A process according to claim 9 in which the daily carbidopa dose level if from 1-6 mg/kg of mammalian body weight.
Claim 15
Independent Claim
32 words
A method for lowering blood pressure in hypertensive mammals in need of treatment which comprises the administration to such a mammal of an antihypertensive amount of fluoxetine or a pharmaceutically-acceptable salt thereof.
Claim 16
Independent Claim
32 words
A method for lowering blood pressure in hypertensive mammals in need of treatment which comprises the administration to such a mammal of an antihypertensive amount of fluoxetine or a pharmaceutically-acceptable salt thereof.
Claim 17
Dependent Claim
20 words
A process according to claim 13 in which fluoxetine or a pharmaceutically-acceptable salt thereof is administered by the oral route.
Claim 18
Dependent Claim
12 words
A process according to claim 13 in which fluoxetine hydrochloride is administered.
Claim 19
Dependent Claim
21 words
A process according to claim 13 in which the fluoxetine daily dose level is from 0.5-2.0 mg/kg of mammalian body weight.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-05-10 | 1985-11-09 | 1986-05-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-05-10 | 1989-11-09 | 1990-05-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-05-10 | 1993-11-09 | 1994-05-11 | $7700.00 | Window Closed / Lapsed |