Patent US3429030A successfully refreshed from Google Patents.
US4329331A
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Diagnostic method for detection of systemic lupus erythematosus
Assignee: Individual
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Filing: 1980-03-13
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Granted: 1982-05-11
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Expires: 2000-03-13
Abstract
Abstract Systemic lupus erythematosus is diagnosed by contacting the blood serum of a patient with anaplasma antigen derived from a vertebrate infected by an organism of the genus Anaplasmataceae and thereafter contacting the antigen with an indicator for human immunoglobulin components.
Inventors
- 👤 Charles A. Kallick
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 05:44
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/02; A61K39/0233; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/564; G01N2800/00; G01N2800/10; G01N2800/101; G01N2800/104; Y; Y02; Y02A; Y02A50/00; Y02A50/30; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/947; Y10S530/00; Y10S530/868
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
63 words
A method for determining the presence of systemic lupus erythematosus in a patient which comprises contacting blood serum from said patient with anaplasma antigen derived from a vertebrate infected with an organism of the family Anaplasmataceae, and thereafter contacting said antigen with an indicator for human immunoglobulin components and determining the presence of systemic lupus erythematosus by a positive reaction to said indicator.
Claim 2
Independent Claim
63 words
A method for determining the presence of systemic lupus erythematosus in a patient which comprises contacting blood serum from said patient with anaplasma antigen derived from a vertebrate infected with an organism of the family Anaplasmataceae, and thereafter contacting said antigen with an indicator for human immunoglobulin components and determining the presence of systemic lupus erythematosus by a positive reaction to said indicator.
Claim 3
Dependent Claim
12 words
The method of claim 1 wherein said organism is Anaplasma marginale (AM).
Claim 4
Dependent Claim
11 words
The method of claim 2 wherein vertebrate is a bovine animal.
Claim 5
Dependent Claim
42 words
The method of claim 1 wherein said indicator is a goat-derived antihuman gamma globulin conjugated with fluorescein isothiocyanate and determining the presence of systemic lupus erythematosus by the presence of fluorescence in the product obtained by contacting said antigen with said indicator.
Claim 6
Dependent Claim
25 words
The method of claim 4 wherein said goat-derived antihuman gamma globulin conjugated with fluorescein isothiocyanate is first absorbed with anaplasma antigen at a low titer.
Claim 7
Dependent Claim
20 words
The method of claim 1 wherein said anaplasma antigen is in the form of a smear on a glass plate.
Claim 8
Dependent Claim
16 words
The method of claim 6 wherein said smear is dried and preserved in a frozen state.
Claim 9
Dependent Claim
29 words
The method of claim 1 wherein said blood serum is diluted to a strength not higher than about 1/20 of its original strength before being contacted with said antigen.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-05-10 | 1985-11-09 | 1986-05-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-05-10 | 1989-11-09 | 1990-05-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-05-10 | 1993-11-09 | 1994-05-11 | $7700.00 | Window Closed / Lapsed |