US4328216A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Novel organosilicon compounds and anti-tumor agents containing the same
Assignee: Shin-Etsu Chemical Co Ltd
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Filing: 1979-12-10
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Granted: 1982-05-04
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Expires: 1999-12-10
Abstract
Abstract The invention provides a novel anti-tumor agent highly effective for inhibiting growth of several tumor or cancer cells with low toxicity. The active ingredient contained in the anti-tumor agent is an omega -triorganosilyl-substituted linear alkanoic acid anilide which is a hitherto unknown novel compound prepared by the reaction of corresponding acid chloride and aniline.
Inventors
- 👤 Shigeshi Toyoshima
- 👤 Ryuichi Sato
- 👤 Koichi Ito
- 👤 Toshio Shinohara
- 👤 Yasushi Yamamoto
- 👤 Shoji Ichinohe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 16:48
CPC Classifications
C; C07; C07F; C07F7/00; C07F7/02; C07F7/08; C07F7/0803; C07F7/081; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
40 words
An ω-triorganosilyl-substituted linear alkanoic acid anilide represented by the formula ##STR4## where R is a monovalent hydrocarbon group having from 1 to 10 carbon atoms, unsubstituted or substituted with halogen atoms and n is an integer from 1 to 5.
Claim 2
Dependent Claim
40 words
An ω-triorganosilyl-substituted linear alkanoic acid anilide represented by the formula ##STR4## where R is a monovalent hydrocarbon group having from 1 to 10 carbon atoms, unsubstituted or substituted with halogen atoms and n is an integer from 1 to 5.
Claim 3
Dependent Claim
2 words
4-Trimethylsilylbutyric anilide.
Claim 4
Dependent Claim
2 words
4-Trimethylsilylbutyric anilide.
Claim 5
Dependent Claim
2 words
Dimethylphenylsilyl acetanilide.
Claim 6
Dependent Claim
2 words
Dimethylphenylsilyl acetanilide.
Claim 7
Dependent Claim
2 words
4-Diethylmethylsilylbutyric anilide.
Claim 8
Dependent Claim
2 words
4-Diethylmethylsilylbutyric anilide.
Claim 9
Dependent Claim
57 words
An agent for inhibiting of melanoma and Lewis lung cancer comprising an ω-triorganosilyl-substituted linear alkanoic acid anilide represented by the formula ##STR5## where R is a monovalent hydrocarbon group having from 1 to 10 carbon atoms unsubstituted or substit and n is an integer from 1 to 5, in a therapeutically effective amount and a carrier therefor.
Claim 10
Dependent Claim
57 words
An agent for inhibiting of melanoma and Lewis lung cancer comprising an ω-triorganosilyl-substituted linear alkanoic acid anilide represented by the formula ##STR5## where R is a monovalent hydrocarbon group having from 1 to 10 carbon atoms unsubstituted or substit and n is an integer from 1 to 5, in a therapeutically effective amount and a carrier therefor.
Claim 11
Dependent Claim
17 words
The agent as claimed in claim 5 wherein the ω-triorganosilyl-substituted linear alkanoic acid anilide is 4-trimethylsilylbutyric anilide.
Claim 12
Dependent Claim
17 words
The agent as claimed in claim 5 wherein the ω-triorganosilyl-substituted linear alkanoic acid anilide is dimethylphenylsilyl acetanilide.
Claim 13
Dependent Claim
17 words
The agent as claimed in claim 5 wherein the ω-triorganosilyl-substituted linear alkanoic acid anilide is 4-diethylmethylsilylbutyric anilide.
References Cited (Backward Citations)
US3068152A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-05-03 | 1985-11-02 | 1986-05-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-05-03 | 1989-11-02 | 1990-05-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-05-03 | 1993-11-02 | 1994-05-04 | $7700.00 | Window Closed / Lapsed |