US4325972A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Perfluorinated N,N-dimethyl cyclohexylmethylamine emulsions
Assignee: Air Products and Chemicals Inc
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Filing: 1981-06-30
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Granted: 1982-04-20
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Expires: 2001-06-30
Abstract
Abstract Benzyl dimethyl amine is subject to electrofluorination in anhydrous HF to produce perfluoro-N,N-dimethylcyclohexylmethylamine. The obtained perfluoro compound is emulsified with the aid of a nonionic surfactant to form a stable emulsion showing promising use for administration as a blood substitute.
Inventors
- 👤 Robert P. Geyer
- 👤 Frederick L. Herman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:21
CPC Classifications
C; C25; C25B; C25B3/00; C25B3/20; C25B3/27; C25B3/28; C25B3/01; C25B3/09; C25B3/11
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
17 words
A synthetic blood composition comprising a mammalian blood substitute aqueous emulsion containing an effective amount of perfluoro-N,N-dimethylcyclohexylmethylamine.
Claim 2
Dependent Claim
17 words
A synthetic blood composition comprising a mammalian blood substitute aqueous emulsion containing an effective amount of perfluoro-N,N-dimethylcyclohexylmethylamine.
Claim 3
Dependent Claim
23 words
A composition as defined in claim 1 further comprising an emulsifying agent a nonionic surfactant having a molecular weight of 5,000 to 15,000.
Claim 4
Dependent Claim
25 words
A composition as defined in claim 1 further comprising as emulsifying agent a polyoxyethylene-polyoxypropylene copolymer, wherein the particle size is predominantly less than 0.3 microns.
Claim 5
Dependent Claim
23 words
A composition as defined in claim 1 wherein said emulsion comprises electrolyte in quantity sufficient to adjust the osmolality to about 290 mOs.
Claim 6
Independent Claim
46 words
The method of preparing a stable emulsion, which comprises subjecting to sonication an aqueous mixture of perflouro-N-N-dimethylcyclohexylmethylamine and nonionic surfactant for a period of time sufficient to obtain a predominant particle size of less than 0.3 microns and few, if any, particles larger than 0.5 microns.
Claim 7
Independent Claim
46 words
The method of preparing a stable emulsion, which comprises subjecting to sonication an aqueous mixture of perflouro-N-N-dimethylcyclohexylmethylamine and nonionic surfactant for a period of time sufficient to obtain a predominant particle size of less than 0.3 microns and few, if any, particles larger than 0.5 microns.
Claim 8
Dependent Claim
23 words
The method defined in claim 5 wherein the obtained emulsion is adjusted to an osmolality of about 290 mOs by addition of electrolyte.
Claim 9
Dependent Claim
59 words
An aqueous oxygen-transporting emulsion suitable for use as a blood substitute, which comprises 5 to 35% by volume of perfluoro-N,N-dimethyl-cyclohexylmethylamine emulsified in a physiologically acceptable aqueous medium with a nonionic surfactant as the emulsifying agent, said emulsion further containing water soluble electrolyte salts; the particle size of the emulsified material being substantially entirely not in excess of 0.3 micron.
Claim 10
Dependent Claim
59 words
An aqueous oxygen-transporting emulsion suitable for use as a blood substitute, which comprises 5 to 35% by volume of perfluoro-N,N-dimethyl-cyclohexylmethylamine emulsified in a physiologically acceptable aqueous medium with a nonionic surfactant as the emulsifying agent, said emulsion further containing water soluble electrolyte salts; the particle size of the emulsified material being substantially entirely not in excess of 0.3 micron.
References Cited (Backward Citations)
US3989843A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-04-19 | 1985-10-19 | 1986-04-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-04-19 | 1989-10-19 | 1990-04-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-04-19 | 1993-10-19 | 1994-04-20 | $7700.00 | Window Closed / Lapsed |