US4324772A
Expired / Lapsed
US
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Process for producing hydroxyapatite
Assignee: Astaris LLC
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Filing: 1980-11-19
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Granted: 1982-04-13
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Expires: 2000-11-19
Abstract
Abstract A continuous process for producing hydroxyapatite which comprises a two-stage reaction in which pH control and reactant flow are carefully regulated.
Inventors
- 👤 James F. Conn
- 👤 Leofwin A. Jessen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 22:09
CPC Classifications
C; C01; C01B; C01B25/00; C01B25/16; C01B25/26; C01B25/32; C01B25/322
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
113 words
A process for producing hydroxyapatite comprising continuously charging to the first stage of a two-stage reactor a slurry of calcium oxide in water and a solution of phosphoric acid in water, allowing said slurry and said solution to react in said first stage under vigorous agitation at a pH such that the viscosity of the reaction mass is near minimum viscosity, continuing said reaction in the second stage of said reactor under vigorous agitation while continuously charging additional solution of aqueous phosphoric acid thereto in an amount sufficient to maintain the pH in said second stage at about 7.0 to about 7.4 and continuously removing a suspension of hydroxyapatite from said second stage.
Claim 2
Dependent Claim
113 words
A process for producing hydroxyapatite comprising continuously charging to the first stage of a two-stage reactor a slurry of calcium oxide in water and a solution of phosphoric acid in water, allowing said slurry and said solution to react in said first stage under vigorous agitation at a pH such that the viscosity of the reaction mass is near minimum viscosity, continuing said reaction in the second stage of said reactor under vigorous agitation while continuously charging additional solution of aqueous phosphoric acid thereto in an amount sufficient to maintain the pH in said second stage at about 7.0 to about 7.4 and continuously removing a suspension of hydroxyapatite from said second stage.
Claim 3
Dependent Claim
21 words
Process of claim 1 wherein said first stage reaction is conducted at a pH of from about 9.5 to about 11.
Claim 4
Dependent Claim
17 words
Process of claim 2 wherein said first stage reaction is conducted at a pH of about 10.5.
Claim 5
Dependent Claim
21 words
Process of claim 1 wherein said second stage reaction is conducted at a pH of from about 7.2 to about 7.3.
Claim 6
Dependent Claim
21 words
Process of claim 2 wherein said second stage reaction is conducted at a pH of from about 7.2 to about 7.3.
Claim 7
Dependent Claim
21 words
Process of claim 3 wherein said second stage reaction is conducted at a pH of from about 7.2 to about 7.3.
Claim 8
Dependent Claim
60 words
Process of claim 1 wherein the rate of charging of said phosphoric acid solution and said lime slurry is maintained at a ratio such that from about 70 to about 94 percent of said slurry is converted to hydroxyapatite in said first stage and from about 6 to about 30 percent of said slurry is converted in said second stage.
Claim 9
Dependent Claim
38 words
Process of claim 7 wherein said ratio is maintained such that about 90 percent of said slurry is converted to hydroxyapatite in said first stage and about 10 percent of said slurry is converted in said second stage.
Claim 10
Dependent Claim
21 words
Process of claim 1 wherein said reaction is carried out at a temperature of from about 35° to about 90° C.
Claim 11
Dependent Claim
16 words
Process of claim 1 wherein said suspension of hydroxyapatite is flash-dried to afford submicron, powdered hydroxyapatite.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-04-12 | 1985-10-12 | 1986-04-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-04-12 | 1989-10-12 | 1990-04-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-04-12 | 1993-10-12 | 1994-04-13 | $7700.00 | Window Closed / Lapsed |