US4323486A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Albumin-fixed resin, production thereof, and therapeutical use thereof
Assignee: Teijin Ltd
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Filing: 1980-11-12
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Granted: 1982-04-06
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Expires: 2000-11-12
Abstract
Abstract The present invention provides an albumin-fixed resin comprising a crosslinked water-insoluble resin and albumin chemically bound thereto, said water-insoluble resin being a crosslinked epoxy resin containing about 1 to about 30 milliequivalents of amino groups and about 1 to about 50 milliequivalents of hydroxyl groups per gram thereof, said albumin being ionically bound to the amino groups of the epoxy resin and to the hydroxyl groups by hydrogen bonding, and the amount of said albumin fixed being at least about 25% by weight based on the epoxy resin, and also provides a process for producing the albumin-fixed resin, which comprises (1) (a) subjecting a polyepoxy compound containing at least two epoxy groups in the molecule and a polyamine compound containing at least two primary and/or secondary amino groups in the molecule to addition reaction in an inert medium to produce a fully crosslinked resin, or (b) subjecting said compounds to addition reaction to produce an insufficiently crosslinked pre-polymer, and then reacting the pre-polymer with at least one compound selected from the group consisting of organic polyisocyanates, organic polyisothiocyanates and organic polycarboxylic acid halides to crosslink it fully, and (2) contacting the resulting crosslinked epoxy resin containing about 1 to about 30 milliequivalents of amino groups and about 1 to about 50 milliequivalents of hydroxyl groups per gram thereof intimately with an aqueous solution containing albumin optionally after partially neutralizing the amino groups of the epoxy resin. The albumin-fixed resin is useful for removing albumin-binding noxious substances such as bilirubin contained in the blood of a warm-blooded animal.
Inventors
- 👤 Hideaki Suzuki
- 👤 Gentaro Yamashita
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:43
CPC Classifications
C; C08; C08G; C08G81/00; A; A61; A61L; A61L33/00; A61L33/06; A61L33/068; A61M; A61M1/00; A61M1/36; A61M1/3687; B; B01; B01D; B01D15/00; B01D15/08; B01J; B01J20/00; B01J20/22; B01J20/26; B01J20/262; B01J20/265; B01J20/267; B01J20/28; B01J20/28014; B01J20/28016; B01J20/28019; B01J20/30; B01J20/3092; B01J20/32; B01J20/3202; B01J20/3206; B01J20/3208; B01J20/3212; B01J20/3214; B01J20/3217; B01J20/3221; B01J20/3231; B01J20/3242; B01J20/3268; B01J20/3272; B01J20/3274; C08G18/00; C08G18/06; C08G18/28; C08G18/30; C08G18/32; C08G18/3225; C08G18/3228; C08G18/3246; C08G18/325; C08G18/40; C08G18/58; C08G18/584; C08G18/70; C08G18/72; C08G18/74; C08G18/76; C08G18/7657; C08G18/7664; C08G18/7671; C08L; C08L63/00; B01J2220/00; B01J2220/50; B01J2220/58
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
92 words
An albumin-fixed resin comprising a crosslinked water-insoluble resin and albumin chemically bound thereto, said water-insoluble resin being a crosslinked epoxy resin containing about 1 to about 30 milliequivalents of at least one of primary, secondary, and tertiary amino groups and about 1 to about 50 milliequivalents of hydroxyl groups per gram thereof, said albumin being ionically bound to the amino groups of the epoxy resin and to the hydroxyl groups by hydrogen bonding, and the amount of said albumin fixed being at least about 25% by weight based on the epoxy resin.
Claim 2
Dependent Claim
92 words
An albumin-fixed resin comprising a crosslinked water-insoluble resin and albumin chemically bound thereto, said water-insoluble resin being a crosslinked epoxy resin containing about 1 to about 30 milliequivalents of at least one of primary, secondary, and tertiary amino groups and about 1 to about 50 milliequivalents of hydroxyl groups per gram thereof, said albumin being ionically bound to the amino groups of the epoxy resin and to the hydroxyl groups by hydrogen bonding, and the amount of said albumin fixed being at least about 25% by weight based on the epoxy resin.
Claim 3
Dependent Claim
34 words
The albumin-fixed resin of claim 1 wherein said crosslinked epoxy resin contains about 2 to about 20 milliequivalents of amino groups and about 2 to about 35 milliequivalents of hydroxyl groups per gram thereof.
Claim 4
Dependent Claim
34 words
The albumin-fixed resin of claim 2 wherein the crosslinked epoxy resin contains about 4 to about 10 milliequivalents of amino groups and about 4 to about 25 milliequivalents of hydroxyl groups per gram thereof.
Claim 5
Dependent Claim
25 words
The albumin-fixed resin of claim 1 wherein the amount of albumin fixed is about 25 to about 150% by weight based on the epoxy resin.
Claim 6
Dependent Claim
21 words
The albumin-fixed resin of claim 1 wherein the crosslinked epoxy resin is derived from a polyepoxy compound and a polyamine compound.
Claim 7
Dependent Claim
48 words
The albumin-fixed resin of claim 1 wherein the crosslinked epoxy resin is derived from an insufficiently crosslinked pre-polymer obtained by reacting a polyepoxy compound with a polyamine compound, and at least one compound selected from the group consisting of organic polyisocyanates, organic polyisothiocyanates and organic polycarboxylic acid halides.
Claim 8
Dependent Claim
148 words
A process for producing the albumin-fixed resin of claim 1, which comprises (1) (a) subjecting a polyepoxy compound containing at least two epoxy groups in the molecule and a polyamine compound containing at least two primary and/or secondary amino groups in the molecule to addition reaction in an inert medium to produce a fully crosslinked resin, or (b) subjecting said compounds to addition reaction to produce an insufficiently crosslinked pre-polymer, and then reacting the pre-polymer with at least one compound selected from the group consisting of organic polyisocyanates, organic polyisothiocyanates and organic polycarboxylic acid halides to crosslink it fully, and (2) contacting the resulting crosslinked epoxy resin containing about 1 to about 30 milliequivalents of amino groups and about 1 to about 50 milliequivalents of hydroxyl groups per gram thereof intimately with an aqueous solution containing albumin optionally after partially neutralizing the amino groups of the epoxy resin.
Claim 9
Dependent Claim
15 words
The process of claim 7 wherein the polyepoxy compound is a di- or tri-glycidyl ether.
Claim 10
Dependent Claim
58 words
The process of claim 8 wherein the diglycidyl ether is selected from a compound of the formula ##STR10## wherein n is a number of 2 to 10, a compound of the formula ##STR11## wherein m is a number of 2 to 10, glycerol diglycidyl ether, bisphenol A diglycidyl ether, hydroquinone diglycidyl ether, resorcinol diglycidyl ether and mixtures thereof.
Claim 11
Dependent Claim
30 words
The process of claim 8 wherein the triglycidyl ether is selected from the group consisting of glycerol triglycidyl ether, 1,1,1-trimethylolpropane triglycidyl ether, phloroglucinol triglycidyl ether, triglycidyl isocyanurate and mixtures thereof.
Claim 12
Dependent Claim
89 words
The process of claim 7 wherein the polyamine compound is an aliphatic diamine, an alicyclic diamine, an aromatic diamine, or a polyalkylenepolyamine of the formula ##STR12## wherein R 1 and R 2 are identical or different, and each represents a hydrogen atom, or an alkyl, alkenyl, hydroxyalkyl, aryl or aralkyl group, R 3 represents a hydrogen atom or a beta-aminoethyl group, and p is a number of 2 to 10, provided that two or more R 3 groups, independently from each other, may be hydrogen atoms or beta-aminoethyl groups.
Claim 13
Dependent Claim
35 words
The process of claim 11 wherein the aliphatic diamine is a compound of the following formula H.sub.2 N--(CH.sub.2).sub.q NH.sub.2 wherein q is an integer of 2 to 10, or a compound of the formula ##STR13##
Claim 14
Dependent Claim
19 words
The process of claim 11 wherein the alicyclic diamine is piperazine, 2,5-dimethylpiperazine or diaminocyclohexane of the following formula ##STR14##
Claim 15
Dependent Claim
39 words
The process of claim 11 wherein the aromatic diamine is a diaminobenzene of the formula ##STR15## or a diaminobisphenylene compound of the formula ##STR16## wherein X represents a bond, a methylene group, a dimethylmethylene group, or an oxygen atom.
Claim 16
Dependent Claim
37 words
The process of claim 7 wherein step (1), (a) is performed using 0.5 to 2.0 equivalents of the epoxy groups of the polyepoxy compound per equivalent of the primary and/or secondary amino groups of the polyamine compound.
Claim 17
Dependent Claim
38 words
The process of claim 7 wherein step (1), (b) is carried out using 0.5 to 2.0 equivalents of the epoxy groups of the polyepoxy compound per equivalent of the primary and/or secondary amino groups of the polyamine compound.
Claim 18
Dependent Claim
52 words
The process of claim 7 wherein the addition reaction of the polyepoxy compound and the polyamine compound is carried out by dispersing in an aqueous medium in the optional presence of a dispersant a solution of the polyepoxy compound and the polyamine compound in a water-insoluble or sparingly water-soluble inert organic solvent.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-04-05 | 1985-10-05 | 1986-04-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-04-05 | 1989-10-05 | 1990-04-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-04-05 | 1993-10-05 | 1994-04-06 | $7700.00 | Window Closed / Lapsed |