US4320146A
Expired / Lapsed
US
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Treatment of hepatic and renal disorders with ornithine and arginine salts of branched chain keto acids
Assignee: Johns Hopkins University
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Filing: 1980-10-02
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Granted: 1982-03-16
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Expires: 2000-10-02
Abstract
Abstract Novel compounds are prepared by reacting ornithine or arginine with alpha ketao analogs of branched chain essential amino acids, namely valine, leucine and isoleucine. The compounds are useful either individually or as a mixture in the treatment of hepatic disorders which are characterized by hyperammonemia and portal systemic encephalopathy. Use of these compounds in treatment of renal failure also appears promising.
Inventors
- 👤 Mackenzie Walser
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 14:04
CPC Classifications
C; C07; C07C; C07C59/00; C07C59/185
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
65 words
A composition for promoting protein synthesis by improving nitrogen balance in subjects with liver disease comprising a carrier and an effective amount of at least one compound having the formula: AK.xH.sub.2 O wherein A is selected from the group consisting of arginine and ornithine, K is an alpha keto analog of a branched chain essential amino acid, and x varies from zero to about one.
Claim 2
Dependent Claim
65 words
A composition for promoting protein synthesis by improving nitrogen balance in subjects with liver disease comprising a carrier and an effective amount of at least one compound having the formula: AK.xH.sub.2 O wherein A is selected from the group consisting of arginine and ornithine, K is an alpha keto analog of a branched chain essential amino acid, and x varies from zero to about one.
Claim 3
Dependent Claim
25 words
A composition according to claim 1 comprising a mixture of said compounds formed from each of the alpha keto analogs of valine, leucine and isoleucine.
Claim 4
Dependent Claim
17 words
A composition according to claim 2 comprising a mixture of arginine alpha-ketoisocaproate, arginine alpha-ketoisovalerate and arginine alpha-keto-beta-methylvalerate.
Claim 5
Dependent Claim
15 words
A composition according to claim 3 wherein said compounds are present in approximately equimolar amounts.
Claim 6
Independent Claim
52 words
A method for promoting protein synthesis by improving nitrogen balance in subjects with liver disease which method comprises oral or parenteral administration in effective dosages to subjects suffering from this condition of a composition comprising a mixture of arginine and/or ornithine salts of alpha keto analogs of branched chain essential amino acids.
Claim 7
Independent Claim
52 words
A method for promoting protein synthesis by improving nitrogen balance in subjects with liver disease which method comprises oral or parenteral administration in effective dosages to subjects suffering from this condition of a composition comprising a mixture of arginine and/or ornithine salts of alpha keto analogs of branched chain essential amino acids.
Claim 8
Dependent Claim
17 words
A method according to claim 5 wherein the mixture comprises arginine alpha-ketoisocaproate, arginine alpha-ketoisovalerate and arginine alpha-keto-beta-methylvalerate.
Claim 9
Dependent Claim
18 words
A method according to claim 6 wherein said salts are present in the composition in approximately equimolar amounts.
Claim 10
Dependent Claim
15 words
A method according to claim 7 wherein said salts are administered orally in dry form.
Claim 11
Dependent Claim
20 words
A method according to claim 7 wherein the daily dosage is approximately 30 to 40 millimoles of the total composition.
Claim 12
Independent Claim
72 words
A method for promoting protein synthesis by improving nitrogen balance in subjects with liver disease comprising oral or parenteral administration in effective dosages to subjects suffering from this condition of at least one compound having the formula: AK.xH.sub.2 O wherein A is selected from the group consisting of arginine and ornithine, K is an alpha keto analog of a branched chain essential amino acid, and X varies from zero to about one.
Claim 13
Independent Claim
72 words
A method for promoting protein synthesis by improving nitrogen balance in subjects with liver disease comprising oral or parenteral administration in effective dosages to subjects suffering from this condition of at least one compound having the formula: AK.xH.sub.2 O wherein A is selected from the group consisting of arginine and ornithine, K is an alpha keto analog of a branched chain essential amino acid, and X varies from zero to about one.
Claim 14
Dependent Claim
12 words
A method according to claim 9 wherein said compound is arginine alpha-ketoisocaproate.
Claim 15
Dependent Claim
12 words
A method according to claim 9 wherein said compound is ornithine alpha-ketoisocaproate.
Claim 16
Independent Claim
64 words
A method for treatment of renal failure comprising oral or parenteral administration in effective dosages to subjects suffering from this condition of at least one compound having the formula: AK.xH.sub.2 O wherein A is selected from the group consisting of arginine and ornithine, K is an alpha keto analog of a branched chain essential amino acid, and x varies from zero to about one.
Claim 17
Independent Claim
64 words
A method for treatment of renal failure comprising oral or parenteral administration in effective dosages to subjects suffering from this condition of at least one compound having the formula: AK.xH.sub.2 O wherein A is selected from the group consisting of arginine and ornithine, K is an alpha keto analog of a branched chain essential amino acid, and x varies from zero to about one.
References Cited (Backward Citations)
CA814483A
Cited
GB1034358A
Cited
FR1432756A
Cited
US3441650A
Cited
FR2226993B1
Cited
US4100293A
Cited
US3950529A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-03-15 | 1985-09-14 | 1986-03-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-03-15 | 1989-09-14 | 1990-03-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-03-15 | 1993-09-14 | 1994-03-16 | $7700.00 | Window Closed / Lapsed |