US4320145A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical composition for parenteral nutrition comprising L-carnitine or acyl L-carnitines
Assignee: Individual
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Filing: 1980-09-29
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Granted: 1982-03-16
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Expires: 2000-09-29
Abstract
Abstract A glucose solution for drip phleboclysis characterized by the inclusion therein of L-carnitine is disclosed. The presence of L-carnitine improves the muscle tissue absorption and utilization of glucose, thus preventing excessive insulin secretion. This permits the utilization of 10% glucose solutions, and also in excess of 10%, without any risk for the patient even in the case of long-term treatment.
Inventors
- 👤 Claudio Cavazza
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 05:59
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/01
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
92 words
A parenterally administrable pharmaceutical composition useful for nourishing patients who cannot be fed via the enteral route, consisting essentially a nutritionally effective amount of glucose, an amount of L-carnitine or acyl-L-carnitine wherein the acyl group has 2-6 carbon atoms, or a pharmaceutically acceptable salt, ester or amide thereof, sufficient to enhance glucose utilization whilst avoiding excessive insulin secretion in said patients, said L-carnitine or acyl-L-carnitine being solely the L-isomer or a mixture of the L- and D-isomers in an L:D ratio of at least 95:5; and a pharmaceutically acceptable liquid excipient therefor.
Claim 2
Dependent Claim
92 words
A parenterally administrable pharmaceutical composition useful for nourishing patients who cannot be fed via the enteral route, consisting essentially a nutritionally effective amount of glucose, an amount of L-carnitine or acyl-L-carnitine wherein the acyl group has 2-6 carbon atoms, or a pharmaceutically acceptable salt, ester or amide thereof, sufficient to enhance glucose utilization whilst avoiding excessive insulin secretion in said patients, said L-carnitine or acyl-L-carnitine being solely the L-isomer or a mixture of the L- and D-isomers in an L:D ratio of at least 95:5; and a pharmaceutically acceptable liquid excipient therefor.
Claim 3
Dependent Claim
43 words
The pharmaceutical composition of claim 1, administrable by drip phleboclysis, consisting essentially: glucose: 50-300 g/l L-carnitine or acyl-L-carnitine wherein the acyl group has 2-6 carbon atoms, or a pharmaceutically acceptable salt, ester or amide thereof: 1-10 g/l distilled water: balance to 1 liter.
Claim 4
Dependent Claim
24 words
The pharmaceutical composition of claim 2, wherein said acyl group is selected from the group consisting of acetyl, pyruvyl, propionyl, butyryl, hydroxybutyryl and hexanoyl.
Claim 5
Dependent Claim
19 words
The pharmaceutical composition according to claim 1, which also comprises a nutritionally effective amount of a mixture of amino-acids.
Claim 6
Dependent Claim
21 words
The pharmaceutical composition of claim 4, wherein said amount of amino acid mixture is comprised between 25 g/l and 75 g/l.
Claim 7
Dependent Claim
46 words
The pharmaceutical composition of claim 5 comprising: glucose: 50-300 g/l L-carnitine: 1-10 g/l Leucine: 8-10 g/l Valine: 6-8 g/l Lysine: 6-8 g/l Isoleucine: 5-6 g/l Phenylalanine: 4-5 g/l Threonine: 3-4.5 g/l Methionine: 2.5-3.5 g/l Histidine: 2.5-3.5 g/l Tryptophan: 0.5-1.0 g/l Distilled water: balance to 1 l.
Claim 8
Dependent Claim
60 words
The pharmaceutical composition of claim 5 comprising: glucose: 50-300 g/l L-carnitine: 1-10 g/l L-leucine: 6.5-8 g/l L-valine: 1.5-2 g/l L-lysine: 4-5 g/l L-isoleucine: 2.5-3 g/l L-phenylalanine: 1-1.5 g/l L-threonine: 2.5-3 g/l L-methionine: 1-1.5 g/l L-arginine: 2.5-3.5 g/l L-histidine: 1-1.5 g/l L-tryptophan: 0.5-1.0 g/l L-tyrosine: 1-1.5 g/l L-glutamic acid: 0.3-0.5 g/l L-aspartic acid: 0.3-0.5 g/l L-cysteine: 0.3-0.5 g/l glycine: 2-2.5 g/l.
Claim 9
Independent Claim
77 words
A method of nourishing patients in need of parenteral nutrition which comprises administering by the parenteral route to said patients a nutritionally effective amount of glucose and in combination therewith an amount of L-carnitine or acyl-L-carnitine wherein the acyl group has 2-6 carbon atoms, or a pharmaceutically acceptable salt, ester or amide thereof, said L-carnitine or acyl-L-carnitine being solely the L-isomer or a mixture of the L- and D-isomers in an L:D ratio of at least 95:5.
Claim 10
Independent Claim
77 words
A method of nourishing patients in need of parenteral nutrition which comprises administering by the parenteral route to said patients a nutritionally effective amount of glucose and in combination therewith an amount of L-carnitine or acyl-L-carnitine wherein the acyl group has 2-6 carbon atoms, or a pharmaceutically acceptable salt, ester or amide thereof, said L-carnitine or acyl-L-carnitine being solely the L-isomer or a mixture of the L- and D-isomers in an L:D ratio of at least 95:5.
Claim 11
Dependent Claim
45 words
The method of claim 8, which comprises administering by drip phleboclysis the following composition: glucose: 50-300 g/l L-carnitine or acyl-L-carnitine wherein the acyl group has 2-6 carbon atoms, or a pharmaceutically acceptable salt, ester or amide thereof: 1-10 g/l distilled water: balance to 1 liter.
Claim 12
Dependent Claim
38 words
The pharmaceutical composition according to claim 1, consisting essentially of said glucose, a nutritionally effective amount of a mixture of amino acids, said L-carnitine or acyl-L-carnitine or pharmaceutically acceptable salt, ester or amide thereof and said liquid excipient.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-03-15 | 1985-09-14 | 1986-03-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-03-15 | 1989-09-14 | 1990-03-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-03-15 | 1993-09-14 | 1994-03-16 | $7700.00 | Window Closed / Lapsed |