US4320057A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones
Assignee: Wyeth LLC
•
Filing: 1981-03-25
•
Granted: 1982-03-16
•
Expires: 2001-03-25
Abstract
Abstract Aryl-1-mercaptoalkanoylproline and homoproline derivatives and their cyclized thiazadione heterocyclic analogues reduce blood pressure in animals by ACE inhibition.
Inventors
- 👤 Meier E. Freed
- 👤 James L. Diebold
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 16:17
CPC Classifications
C; C07; C07D; C07D513/00; C07D513/02; C07D513/04; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/16; C07D211/00; C07D211/04; C07D211/06; C07D211/36; C07D211/60
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
75 words
A compound of the formula: ##STR4## wherein R 1 and R 2 are independently, hydrogen, alkyl of one to six carbon atoms, alkoxy of one to six carbon atoms or halo; R 3 is hydrogen or alkyl of one to six carbon atoms; R 4 is hydrogen or alkyl of one to six carbon atoms; m is one of the integers 0 or 1; and n is one of the integers 0, 1 or 2.
Claim 2
Dependent Claim
75 words
A compound of the formula: ##STR4## wherein R 1 and R 2 are independently, hydrogen, alkyl of one to six carbon atoms, alkoxy of one to six carbon atoms or halo; R 3 is hydrogen or alkyl of one to six carbon atoms; R 4 is hydrogen or alkyl of one to six carbon atoms; m is one of the integers 0 or 1; and n is one of the integers 0, 1 or 2.
Claim 3
Dependent Claim
45 words
A compound of claim 1 of the formula: ##STR5## wherein R 1 and R 2 are, independently, hydrogen or alkoxy of one to three carbon atoms; R 3 is hydrogen or methyl; and R 4 is hydrogen or alkykl of one to three carbon atoms.
Claim 4
Dependent Claim
8 words
A compound of claim 1 which is trans-hexahydro-7(5,4-dimethoxyphenyl)-1H,5H-pyrrolo[2,1-c][1,4]thiazepine-1,5-dione.
Claim 5
Dependent Claim
8 words
A compound of claim 1 which is trans-hexahydro-7-phenyl-1H,5H-pyrrolo[2,1-c][1,4]thiazepine-1,5-dione.
References Cited (Backward Citations)
US4192945A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-03-15 | 1985-09-14 | 1986-03-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-03-15 | 1989-09-14 | 1990-03-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-03-15 | 1993-09-14 | 1994-03-16 | $7700.00 | Window Closed / Lapsed |