US4317776A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2-Acetyl-and 2-propionylpyridine thiosemicarbazones
Assignee: United States Department of the Army
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Filing: 1979-01-04
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Granted: 1982-03-02
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Expires: 1999-01-04
Abstract
Abstract This invention relates to various 2-acetyl- and 2-propionylpyridine thiosemicarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in addition, many are useful either in the treatment of malaria or bacterial infection. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.
Inventors
- 👤 Daniel L. Klayman
- 👤 John P. Scovill
- 👤 Joseph F. Bartosevich
- 👤 Carl J. Mason
- 👤 T. Scott Griffin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 16:00
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/44; C07D213/53; C07D213/60; C07D213/72; C07D213/74; C07D213/78; C07D213/83; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
69 words
A compound of the formula ##STR9## or a pharmaceutically-acceptable acid addition salt thereof wherein R is methyl or ethyl; and R 1 and R 2 are taken together with the nitrogen atom to which they are attached to form a heterocyclic ring selected from the group consisting of (1) alkylenimino; and (2) alkylenimino which may contain one double bond and/or is mono- disubstituted with alkyl, hydroxy, phenyl or benzyl.
Claim 2
Dependent Claim
69 words
A compound of the formula ##STR9## or a pharmaceutically-acceptable acid addition salt thereof wherein R is methyl or ethyl; and R 1 and R 2 are taken together with the nitrogen atom to which they are attached to form a heterocyclic ring selected from the group consisting of (1) alkylenimino; and (2) alkylenimino which may contain one double bond and/or is mono- disubstituted with alkyl, hydroxy, phenyl or benzyl.
Claim 3
Dependent Claim
11 words
A compound or salt of claim 1 wherein R is methyl.
Claim 4
Dependent Claim
11 words
A compound or salt of claim 1 wherein R is ethyl.
Claim 5
Dependent Claim
14 words
A compound or salt of claim 2 wherein NR 1 R 2 is azetidino.
Claim 6
Dependent Claim
14 words
A compound or salt of claim 2 wherein NR 1 R 2 is pyrrolidino.
Claim 7
Dependent Claim
14 words
A compound or salt of claim 2 wherein NR 1 R 2 is piperidino.
Claim 8
Dependent Claim
14 words
A compound or salt of claim 2 wherein NR 1 R 2 is 2-methylpiperidino.
Claim 9
Dependent Claim
14 words
A compound or salt of claim 2 wherein NR 1 R 2 is 2-ethylpiperidino.
Claim 10
Dependent Claim
14 words
A compound or salt of claim 2 wherein NR 1 R 2 is hexamethylenimino.
Claim 11
Dependent Claim
14 words
A compound or salt of claim 3 wherein NR 1 R 2 is hexamethylenimino.
Claim 12
Dependent Claim
14 words
A compound or salt of claim 2 wherein NR 1 R 2 is azacyclotridecyl.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-03-01 | 1985-08-31 | 1986-03-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-03-01 | 1989-08-31 | 1990-03-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-03-01 | 1993-08-31 | 1994-03-02 | $7700.00 | Window Closed / Lapsed |