US4317775A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Amoxicillin derivatives
Assignee: Hoffmann La Roche Inc
•
Filing: 1980-01-07
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Granted: 1982-03-02
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Expires: 2000-01-07
Abstract
Abstract The compound 6-[D(-)alpha-amino-phenylacetamido]penicillanic acid and salts or hydrates thereof wherein the amino group is substituted with a 5 to 6-membered heterocyclic ring, useful as antibacterial therapeutic agents in the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria and which are stable in aqueous solutions.
Inventors
- 👤 Kasper F. Burri
- 👤 Perry Rosen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 18:10
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/02; C07D307/26; C07D307/30; C07D307/32; C07D307/33; A; A61; A61P; A61P31/00; A61P31/04; C07D307/04; C07D307/18; C07D307/20; C07D309/00; C07D309/02; C07D309/08; C07D309/10; C07D309/16; C07D309/28; C07D309/30; C07D333/00; C07D333/02; C07D333/04; C07D333/26; C07D333/30; C07D333/32; C07D333/38; C07D335/00; C07D335/02; C07D499/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
100 words
A compound of the formula: ##STR9## wherein R is hydrogen or hydroxy, R 1 and R 2 are individually hydrogen, or a saturated heterocyclic 5 to 6 membered ring containing one hetero atom selected from the group consisting of oxygen and sulfur, said hetero atom being positioned in said ring adjacent the carbon atom in said ring connected to the nitrogen atom, said ring being unsubstituted or substituted in one or more positions with lower alkyl or halogen, with the proviso that at least one of R 1 and R 2 is other than hydrogen; salts, hydrates or esters thereof.
Claim 2
Dependent Claim
100 words
A compound of the formula: ##STR9## wherein R is hydrogen or hydroxy, R 1 and R 2 are individually hydrogen, or a saturated heterocyclic 5 to 6 membered ring containing one hetero atom selected from the group consisting of oxygen and sulfur, said hetero atom being positioned in said ring adjacent the carbon atom in said ring connected to the nitrogen atom, said ring being unsubstituted or substituted in one or more positions with lower alkyl or halogen, with the proviso that at least one of R 1 and R 2 is other than hydrogen; salts, hydrates or esters thereof.
Claim 3
Dependent Claim
11 words
The compound of claim 1 wherein said penicillin is {2S-[2alpha,5alpha,6beta(S*)]}-6-{[2-tetrahydrofuranylamino(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.
Claim 4
Dependent Claim
11 words
The compound of claim 1 wherein said penicillin is {2S-[2alpha,5alpha,6beta(S*)]}-6-[bis(tetrahydro-2H-pyran-2-yl)amino]{[(4-hydroxyphenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-3-carboxylic acid.
Claim 5
Dependent Claim
12 words
The compound of claim 1 wherein said penicillin is {2S-[2alpha,5alpha,6beta(S*)]}-6-{[tetrahydro-2-thienylamino-(4-hydroxyphenyl)acetyl amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.
Claim 6
Dependent Claim
11 words
The compound of claim 1 wherein said penicillin is {2S[2alpha,5alpha,6beta(S*)]}-6-{Bis[5-ethyl-3-fluoro-2-tetrahydrofuranylamino-(4-hydroxyphenyl)-acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo-[3.2.0]heptane-2-carboxylic acid.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-03-01 | 1985-08-31 | 1986-03-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-03-01 | 1989-08-31 | 1990-03-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-03-01 | 1993-08-31 | 1994-03-02 | $7700.00 | Window Closed / Lapsed |