US4315923A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for the production of organ extracts with high herparin content
Assignee: Richter Gedeon Vegyeszeti Gyar Nyrt
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Filing: 1980-03-19
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Granted: 1982-02-16
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Expires: 2000-03-19
Abstract
Abstract A process for producing an aqueous solution of high heparin content from heparin-containing animal organs comprises forming a heparin-enriched granular raw material from these organs and extracting the raw material at a temperature of 20 DEG to 80 DEG C. with a salt solution having a salt concentration of 1.5 to 12.0% and a pH in the range of 8 to 12.8 or an alkalinity of 0.5 normal to 1.08 normal concentration. The dry substance to liquid ratio should be 1:5.
Inventors
- 👤 Istvan Takacs
- 👤 Gyorgy Kerey
- 👤 Janos Illes
- 👤 Peter Rudolf
- 👤 Pal Gere
- 👤 Laszlo Czebe
- 👤 Erzsebet Neszmelyi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 22:51
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0075
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
96 words
A process for the production of an aqueous extract with a heparin content of substantially 150 to 300 NE/ml, comprising the steps of: forming a heparin-enriched amorphous granular raw material containing 90 to 95% by weight dry substance from heparin-containing animal waste; and extracting said granular raw material by counterflow extraction at a temperature between 20° C. and 80° C. with an aqueous salt solution of an electrolyte composition of 1.5 to 12.0% and a pH of 8 to 12.8 or with an alkaline solution of 0.5 normal to 1.0 normal to form the aqueous extract.
Claim 2
Dependent Claim
96 words
A process for the production of an aqueous extract with a heparin content of substantially 150 to 300 NE/ml, comprising the steps of: forming a heparin-enriched amorphous granular raw material containing 90 to 95% by weight dry substance from heparin-containing animal waste; and extracting said granular raw material by counterflow extraction at a temperature between 20° C. and 80° C. with an aqueous salt solution of an electrolyte composition of 1.5 to 12.0% and a pH of 8 to 12.8 or with an alkaline solution of 0.5 normal to 1.0 normal to form the aqueous extract.
Claim 3
Dependent Claim
14 words
The process defined in claim 1 wherein said counterflow extraction is carried out continously.
Claim 4
Dependent Claim
14 words
The process defined in claim 1 wherein said counterflow extraction is carried out intermittently.
Claim 5
Dependent Claim
25 words
The process defined in claim 1, claim 2 or claim 3 wherein the counterflow extraction is carried out in a vibrated U-extractor subdivided into cells.
References Cited (Backward Citations)
US2571679A
Cited
DE950594C
Cited
GB872214A
Cited
US2989438A
Cited
GB1221784A
Cited
US3865723A
Cited
US4175182A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-02-15 | 1985-08-17 | 1986-02-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-02-15 | 1989-08-17 | 1990-02-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-02-15 | 1993-08-17 | 1994-02-16 | $7700.00 | Window Closed / Lapsed |