US4315918A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical formulation of guar gum
Assignee: Cooper Australia Ltd
•
Filing: 1979-08-13
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Granted: 1982-02-16
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Expires: 1999-08-13
Abstract
Abstract The gellation of polysaccharide gums such as guar or locust bean gum is inhibited by gelatin hydrolysates, at alkaline pH. Formulations of gum, gelatin hydrolysate and alkaliniser are reconstituted by shaking with water, and are easily inbibed. The inhibition is reversed by pH change in the stomach allowing gellation to occur. The formulation is useful in treatment of hypercholesteraemia, gastric disorders and as an adjunct to insulin therapy.
Inventors
- 👤 Stephen Gayst
- 👤 Michael J. Maguire
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 22:33
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/08; A61K31/00; A61K31/70; A61K31/715; A61K47/00; A61K47/30; A61K47/42
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
40 words
A pharmaceutical composition for use in medicine, presented as a dry powder suitable for reconstitution by admixture with drinking water, said composition comprising a therapeutically effective, non-toxic amount of a galactomannan admixed with a gellation inhibiting amount of gelatin hydrolysate.
Claim 2
Dependent Claim
40 words
A pharmaceutical composition for use in medicine, presented as a dry powder suitable for reconstitution by admixture with drinking water, said composition comprising a therapeutically effective, non-toxic amount of a galactomannan admixed with a gellation inhibiting amount of gelatin hydrolysate.
Claim 3
Dependent Claim
17 words
A composition as claimed in claim 1 which also comprises an effective adjusting quantity of an alkaliniser.
Claim 4
Dependent Claim
21 words
A composition as claimed in claim 2 wherein the alkaliniser is selected from sodium glycinate, calcium hydroxide or tri-sodium orthophosphate dodecahydrate.
Claim 5
Dependent Claim
32 words
A composition as claimed in claim 2 wherein the quantity of alkaliniser is sufficient to provide, in the reconstituted formulation, a pH in the range of from pH 5.0 to pH 10.5.
Claim 6
Dependent Claim
31 words
A composition as claimed in claim 4 wherein the quantity of alkaliniser is sufficient to provide, in the reconstituted formulation, a pH in the range from pH 8 to pH 10.
Claim 7
Dependent Claim
18 words
A composition as claimed in claim 1 wherein the galactomannan is either guar gum or locust bean gum.
Claim 8
Dependent Claim
18 words
A composition as claimed in claim 1 wherein the gelatin hydrolysate is a bovine or porcine gelatin hydrolysate.
Claim 9
Dependent Claim
25 words
A composition as claimed in claim 1 wherein the gelatin hydrolysate has a number mean molecular weight of from 1×10 4 to 5×10 4 .
Claim 10
Dependent Claim
22 words
A composition as claimed in claim 8 wherein the gelatin hydrolysate has a number mean molecular weight of about 3×10 4 .
Claim 11
Dependent Claim
27 words
A formulation as claimed in any one of claims 1-5, 6, or 7-9 wherein the gelatin hydrolysate to galactomannan ratio is from 0.5:1 to 6:1 by weight.
Claim 12
Dependent Claim
21 words
A composition as claimed in claim 10 wherein the gelatin hydrolysate to galactomannan ratio is from 0.5:1 to 3:1 by weight.
Claim 13
Dependent Claim
21 words
A composition as claimed in claim 11 wherein the gelatin hydrolysate to galactomannan ratio is from 0.5:1 to 1.5:1 by weight.
Claim 14
Dependent Claim
34 words
A composition as claimed in claim 2 wherein the galactomannan is locust bean gum and the alkaliniser is calcium hydroxide, the latter being present at from 7.5 to 10 mg/g of locust bean gum.
Claim 15
Dependent Claim
21 words
A composition as claimed in claim 13 wherein the calcium hydroxide is present at about 8.5 mg/g of locust bean gum.
Claim 16
Dependent Claim
28 words
A composition as claimed in any one of claims 1-5, 6, or 7-9 which comprises from 5 to 15 g of locust bean gum in unit dose form.
Claim 17
Dependent Claim
20 words
A composition as claimed in claim 15 which comprises about 10 g of locust bean gum in unit dose form.
Claim 18
Dependent Claim
40 words
A composition as claimed in any one of claims 2 to 5, 6 or 7-9 wherein the galactomannan is guar gum and the alkaliniser is sodium glycinate, the latter being present at from 20 to 40 mg/g of guar gum.
Claim 19
Dependent Claim
20 words
A composition as claimed in claim 17 wherein the sodium glycinate is present at about 30 mg/g of guar gum.
Claim 20
Dependent Claim
40 words
A composition as claimed in any one of claims 2 to 5, 6 or 7-9 wherein the galactomannan is guar gum and the alkaliniser is calcium hydroxide, the latter being present at from 30 to 50 mg/g of guar gum.
Claim 21
Dependent Claim
20 words
A composition as claimed in claim 19 wherein the calcium hydroxide is present at about 40 mg/g of guar gum.
Claim 22
Dependent Claim
21 words
A composition as claimed in claim 1 which comprises from 5 to 15 g of guar gum in unit dose form.
Claim 23
Dependent Claim
19 words
A composition as claimed in claim 21 which comprises about 10 g of guar gum in unit dose form.
Claim 24
Independent Claim
34 words
A method for inhibiting the gellation of a galactomannan solution, said method comprising the admixture of gelatin hydrolysate and an alkalinizer either simultaneously with or prior to the addition of water to the galactomannan.
Claim 25
Independent Claim
34 words
A method for inhibiting the gellation of a galactomannan solution, said method comprising the admixture of gelatin hydrolysate and an alkalinizer either simultaneously with or prior to the addition of water to the galactomannan.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-02-15 | 1985-08-17 | 1986-02-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-02-15 | 1989-08-17 | 1990-02-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-02-15 | 1993-08-17 | 1994-02-16 | $7700.00 | Window Closed / Lapsed |