US4315028A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of treatment of rheumatoid arthritis
Assignee: Individual
•
Filing: 1979-09-18
•
Granted: 1982-02-09
•
Expires: 1999-09-18
Abstract
Abstract Rheumatoid arthritis is treated with substituted cysteine compounds having a lower toxicity-to-effectiveness ratio than penicillamine. Such compounds are specific alpha-substituted cysteines, beta-monosubstituted cysteines, beta-di-substituted cysteines other than penicillamine, N-acetyl penicillamine and the N-acetyl derivatives of the alpha and beta-substituted compounds mentioned above. Any of the compounds may be used synergistically in combination with suitable copper compounds or with suitable gold compounds in the treatment of arthritis. The same compounds are effective in the treatment of cystinuria and heavy metal poisoning. The same compounds are well as penicillamine are effective in combination with copper in the treatment of heavy metal poisoning.
Inventors
- 👤 Israel H. Scheinberg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 03:46
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/28; A61K31/30
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
35 words
A method of treating rheumatoid arthritis, which comprises administering to a patient suffering from the same, a rheumatoid arthritis treatment effective amount of a complex of penicillamine or N-acetyl penicillamine complexed with gold or copper.
Claim 2
Independent Claim
35 words
A method of treating rheumatoid arthritis, which comprises administering to a patient suffering from the same, a rheumatoid arthritis treatment effective amount of a complex of penicillamine or N-acetyl penicillamine complexed with gold or copper.
Claim 3
Dependent Claim
13 words
A method according to claim 1, wherein penicillamine is used in said complex.
Claim 4
Dependent Claim
14 words
A method according to claim 1, wherein N-acetyl penicillamine is used in said complex.
Claim 5
Dependent Claim
16 words
A method according to claim 1, wherein said penicillamine or N-acetyl penicillamine is complexed with copper.
Claim 6
Independent Claim
54 words
A method of treating rheumatoid arthritis, which comprises administering to a patient suffering from the same, a rheumatoid arthritis treatment effective amount of a mixture of penicillamine or N-acetyl penicillamine with a non-toxic water soluble salt of copper, the mole ratio of the penicillamine or N-acetyl penicillamine to the copper being between about 1.3-5:1.
Claim 7
Independent Claim
54 words
A method of treating rheumatoid arthritis, which comprises administering to a patient suffering from the same, a rheumatoid arthritis treatment effective amount of a mixture of penicillamine or N-acetyl penicillamine with a non-toxic water soluble salt of copper, the mole ratio of the penicillamine or N-acetyl penicillamine to the copper being between about 1.3-5:1.
Claim 8
Dependent Claim
18 words
A method according to claim 1, wherein a complex of penicillamine or N-acetyl penicillamine with gold is used.
Claim 9
Dependent Claim
32 words
A composition for the treatment of rheumatoid arthritis, comprising a pharmaceutically acceptable carrier and a rheumatoid arthritis treatment effective amount of a complex of penicillamine or N-acetyl penicillamine with gold or copper.
Claim 10
Dependent Claim
32 words
A composition for the treatment of rheumatoid arthritis, comprising a pharmaceutically acceptable carrier and a rheumatoid arthritis treatment effective amount of a complex of penicillamine or N-acetyl penicillamine with gold or copper.
Claim 11
Dependent Claim
50 words
A composition for the treatment of rheumatoid arthritis, comprising a pharmaceutically acceptable carrier and a rheumatoid arthritis treatment effective amount of a mixture of penicillamine or N-acetyl penicillamine with a non-toxic water soluble salt of copper, wherein the ratio of penicillamine and N-acetyl penicillamine to copper is between about 1.3-5:1.
Claim 12
Dependent Claim
50 words
A composition for the treatment of rheumatoid arthritis, comprising a pharmaceutically acceptable carrier and a rheumatoid arthritis treatment effective amount of a mixture of penicillamine or N-acetyl penicillamine with a non-toxic water soluble salt of copper, wherein the ratio of penicillamine and N-acetyl penicillamine to copper is between about 1.3-5:1.
Claim 13
Dependent Claim
17 words
A composition according to claim 7, wherein the complex is of penicillamine or N-acetyl penicillamine with copper.
Claim 14
Dependent Claim
23 words
A composition according to claim 7, wherein the complex is of penicillamine or N-acetyl penicillamine with a non-toxic water soluble salt of gold.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-02-08 | 1985-08-10 | 1986-02-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-02-08 | 1989-08-10 | 1990-02-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-02-08 | 1993-08-10 | 1994-02-09 | $7700.00 | Window Closed / Lapsed |