US4311645A
Expired / Lapsed
US
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Synthesis of SRS-active compounds
Assignee: Hoffmann La Roche Inc
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Filing: 1980-03-24
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Granted: 1982-01-19
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Expires: 2000-03-24
Abstract
Abstract A chemical synthesis of an SRS-A active compound from the reaction product of 1-halo-2-octyne and the ether of 2-penten-4-yn-1-ol including intermediates in the synthesis, some of which being antagonists of SRS-A useful for treating allergic reactions.
Inventors
- 👤 Michael Rosenberger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 21:59
CPC Classifications
C; C07; C07D; C07D333/00; C07D333/02; C07D333/46; A; A61; A61P; A61P37/00; A61P37/08; C07C; C07C29/00; C07C29/09; C07C29/10; C07C29/36; C07C29/38; C07C29/40; C07C45/00; C07C45/27; C07C45/29; C07C45/292; C07C47/00; C07C47/20; C07D303/00; C07D303/02; C07D303/38; C07D303/40; C07D303/42; C07B; C07B2200/00; C07B2200/09
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
46 words
A compound of the formula ##STR15## wherein R is CH 3 --CH 2 --CH 2 --CH 2 --CH 2 ; and R 2 is lower alkyl and Δ' designates a trans configuration across the double bond and pharmaceutically acceptable salts thereof where R 2 is hydrogen.
Claim 2
Dependent Claim
46 words
A compound of the formula ##STR15## wherein R is CH 3 --CH 2 --CH 2 --CH 2 --CH 2 ; and R 2 is lower alkyl and Δ' designates a trans configuration across the double bond and pharmaceutically acceptable salts thereof where R 2 is hydrogen.
Claim 3
Dependent Claim
15 words
The compound of claim 1 wherein said compound is (R,S) (All E)-3-(1,3-tetradecadien-5,8-diyn-1-yl)-1-trans-oxiranebutanoic acid methyl ester.
References Cited (Backward Citations)
US3882148A
Cited
US4174402A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-01-18 | 1985-07-20 | 1986-01-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-01-18 | 1989-07-20 | 1990-01-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-01-18 | 1993-07-20 | 1994-01-19 | $7700.00 | Window Closed / Lapsed |