US4308392A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hydroxamic acid derivatives of mercaptoacyl amino acids
Assignee: ER Squibb and Sons LLC
•
Filing: 1980-11-20
•
Granted: 1981-12-29
•
Expires: 2000-11-20
Abstract
Abstract Hydroxamic acid derivatives of certain mercaptoacyl amino acids inhibit the conversion of angiotensin I to angiotensin II in mammals and are useful for the treatment of hypertension.
Inventors
- 👤 Edward W. Petrillo, Jr.
- 👤 Miguel A. Ondetti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 02:27
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/16
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
90 words
A compound having the formula ##STR9## wherein R 1 is hydrogen, alkyl, aryl, arylalkyl or ##STR10## wherein R 5 is alkyl or aryl; R 2 is hydrogen, alkyl, trifluoromethyl, or pentafluoroethyl; R 3 is --CH 2 -- and R 4 is --S-- or R 3 is --S-- and R 4 is --CH 2 --; and n is 0, 1 or 2; wherein the term "aryl" refers to phenyl or phenyl substituted with one, two or three halogen, alkyl, alkoxy, hydroxy, ##STR11## nitro, amino, alkylamino, dialkylamino, trifluoromethyl, cyano or carboxyl groups.
Claim 2
Dependent Claim
90 words
A compound having the formula ##STR9## wherein R 1 is hydrogen, alkyl, aryl, arylalkyl or ##STR10## wherein R 5 is alkyl or aryl; R 2 is hydrogen, alkyl, trifluoromethyl, or pentafluoroethyl; R 3 is --CH 2 -- and R 4 is --S-- or R 3 is --S-- and R 4 is --CH 2 --; and n is 0, 1 or 2; wherein the term "aryl" refers to phenyl or phenyl substituted with one, two or three halogen, alkyl, alkoxy, hydroxy, ##STR11## nitro, amino, alkylamino, dialkylamino, trifluoromethyl, cyano or carboxyl groups.
Claim 3
Dependent Claim
11 words
A compound in accordance with claim 1 wherein n is 1.
Claim 4
Dependent Claim
19 words
A compound in accordance with claim 2 wherein R 3 is --CH 2 -- and R 4 is S.
Claim 5
Dependent Claim
19 words
A compound in accordance with claim 3 wherein R 3 is --S-- and R 4 is --CH 2 --.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-12-28 | 1985-06-29 | 1985-12-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-12-28 | 1989-06-29 | 1989-12-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-12-28 | 1993-06-29 | 1993-12-29 | $7700.00 | Window Closed / Lapsed |