US4305925A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Latex reagent
Assignee: Siemens Healthcare Diagnostics GmbH Germany
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Filing: 1980-05-05
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Granted: 1981-12-15
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Expires: 2000-05-05
Abstract
Abstract What is disclosed is an improved nephelometric method for detecting an antigen or antibody by contact thereof in a liquid medium with particles of a latex reagent comprising latex particles of different sizes loaded with different amounts of a corresponding antibody or antigen and then measuring the light scattered by a latex reagent.
Inventors
- 👤 Wolfgang Kapmeyer
- 👤 Axel Sieber
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 21:28
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54313; Y; Y10; Y10S; Y10S436/00; Y10S436/805
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
77 words
In a method for the nephelometric detection and determination of an antigen or antibody by contacting said antigen or antibody in a liquid medium with a latex reagent comprising latex particles loaded with a corresponding antibody or antigen, respectively, and then measuring the light scattering effected by said latex reagent, the improvement wherein said latex reagent comprises latex particles falling within two different size ranges and respectively loaded with different amounts of said corresponding antibody or antigen.
Claim 2
Dependent Claim
77 words
In a method for the nephelometric detection and determination of an antigen or antibody by contacting said antigen or antibody in a liquid medium with a latex reagent comprising latex particles loaded with a corresponding antibody or antigen, respectively, and then measuring the light scattering effected by said latex reagent, the improvement wherein said latex reagent comprises latex particles falling within two different size ranges and respectively loaded with different amounts of said corresponding antibody or antigen.
Claim 3
Dependent Claim
98 words
A method as in claim 1 wherein said latex reagent comprises a first quantity of particles having a diameter within a first size range from about 0.1 to 0.35 micron, said first quantity of particles being loaded with said corresponding antibody or antigen in an amount from about 0.6 to 3.3 times the weight of said latex reagent, and a second quantity of particles having a diameter between about 0.5 to 2 microns, said second quantity of particles being loaded with said corresponding antibody or antigen in an amount about 0.1 times the weight of said latex reagent.
Claim 4
Dependent Claim
30 words
A method as in claim 2 wherein the ratio by weight of said first quantity of particles to said second quantity of particles is from about 4:1 to about 1:2.
Claim 5
Dependent Claim
12 words
A method as in claim 1 wherein a rheumatoid factor is determined.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-12-14 | 1985-06-15 | 1985-12-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-12-14 | 1989-06-15 | 1989-12-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-12-14 | 1993-06-15 | 1993-12-15 | $7700.00 | Window Closed / Lapsed |