Enkephalin analogues

Claim 1

Compounds of the general formula R-Tyr-X-Gly-B-Y-Z where (a) --X is Gly, aza-Gly, aza-Ala or any D-amino acid residue --B is Phe, N-substituted (particularly N-methyl) -Phe or dehydro-Phe all optionally substituted in the ring, or alternatively cyclohexylalanine --Y is any D- or L-amino acid residue and (b) one or more of the peptide links between Tyr, X, Gly, B and Y is replaced by a group or groups, the same or different, selected from --CH(OH)--CH 2 --, --CH(OR)--CH 2 --, --CH 2 NH--, ##STR34## --CH 2 --NR--, --CO--CH 2 --and (except where X-Gly and the Gly-Gly link is involved) --CH 2 CH 2 -- (where R is an aliphatic or other protective group) and/or any adjacent pair of peptide-bond nitrogen atoms of the backbone is linked to form the structure ##STR35## that is to say a carbonyl or thiocarbonyl group links the nitrogen atoms of adjacent amino acid residues, A and A' being the side chains thereof and optionally further with the nitrogen of one or more remaining peptide groups carrying a protective aliphatic or other group as ##STR36## where R is as below and (c) Z is --NH 2 , --NHR, --N(R) 2 , --OH or --OR where R is as below and (d) R is an aliphatic or other protective group.