US4301160A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Ready for use, injectable, aqueous solutions of alkali metal salts of canrenoic acid and furosemide and process for their preparation
Assignee: Hoechst AG
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Filing: 1980-12-16
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Granted: 1981-11-17
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Expires: 2000-12-16
Abstract
Abstract Ready for use, injectable, aqueous solution of a pH of from 10.2 to 11.2 containing a mixture of an alkali metal salt of canrenoic acid and furosemide without addition of a buffer and process for their preparation.
Inventors
- 👤 Richard Leeb
- 👤 Rainer J. Helbig
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 16:31
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/02; A61K31/00; A61K31/63; A61K31/635; A61K9/00; A61K9/0012; A61K9/0019
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
36 words
Ready for use, injectable, aqueous solution of a pH of from 10.2 to 11.2, characterized in that it contains a mixture of an alkali metal salt of canrenoic acid and furosemide without addition of a buffer.
Claim 2
Dependent Claim
36 words
Ready for use, injectable, aqueous solution of a pH of from 10.2 to 11.2, characterized in that it contains a mixture of an alkali metal salt of canrenoic acid and furosemide without addition of a buffer.
Claim 3
Dependent Claim
15 words
Solution as claimed in claim 1, containing potassium canrenoate and the sodium salt of furosemide.
Claim 4
Dependent Claim
56 words
Process for the manufacture of a ready for use, injectable, aqueous solution of a pH of from 10.2 to 11.2, which comprises suspending canrenoic acid or an alkali metal canrenoate and furosemide in water and adjusting the pH of the suspension to 10.2-11.2 by adding aqueous alkali solution, thereby transforming the suspension into a clear solution.
Claim 5
Dependent Claim
56 words
Process for the manufacture of a ready for use, injectable, aqueous solution of a pH of from 10.2 to 11.2, which comprises suspending canrenoic acid or an alkali metal canrenoate and furosemide in water and adjusting the pH of the suspension to 10.2-11.2 by adding aqueous alkali solution, thereby transforming the suspension into a clear solution.
Claim 6
Dependent Claim
33 words
Process as claimed in claim 3, wherein potassium canrenoate and furosemide are suspended in water and the suspension is adjusted to pH 10.2 to 11.2, preferably 10.6 to 11.0, with sodium hydroxide solution.
Claim 7
Dependent Claim
15 words
Process as claimed in claims 3 or 4, wherein the pH is adjusted to 10.8.
References Cited (Backward Citations)
US3919198A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-11-16 | 1985-05-18 | 1985-11-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-11-16 | 1989-05-18 | 1989-11-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-11-16 | 1993-05-18 | 1993-11-17 | $7700.00 | Window Closed / Lapsed |