US4299963A
Expired / Lapsed
US
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1-Azaxanthone derivatives
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1980-08-13
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Granted: 1981-11-10
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Expires: 2000-08-13
Abstract
Abstract The present invention relates to novel 1-azaxanthone-3-carboxylic acid and its derivatives usable for effective medicines for the treatment of allergic diseases, which are shown by the following formula (I) ##STR1## wherein R 1 is hydrogen, alkyl, phenyl, carboxyl, hydroxyl, alkoxy or amino group which may be unsubstituted or substituted by one alkyl, m is 0, 1 or 2 and R 2 is alkyl, alkoxy, halogen, nitro, hydroxy, carboxyl, butadienylene (--CH═CH--CH═CH--) which forms a benzene ring with any adjacent carbon atoms or amino group which may be unsubstituted or substituted by at least one alkyl, and their physiologically acceptable salts.
Inventors
- 👤 Akira Nohara
- 👤 Hirosada Sugihara
- 👤 Kiyoshi Ukawa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 08:47
CPC Classifications
C; C07; C07D; C07D491/00; C07D491/02; C07D491/04; C07D311/00; C07D311/02; C07D311/04; C07D311/58
Claims Analysis
Total Claims: 39
Claim 1
Independent Claim
99 words
A compound of the formula: ##STR6## wherein m is 1 or 2; R ' 1 is hydrogen, C 1-6 alkyl, phenyl, C 1-6 alkoxy-carbonyl, hydroxy, C 1-4 alkoxy, amino or C 1-3 alkylamino; each R 2 is independently C 1-6 alkyl, C 1-4 alkoxy, halogen, nitro, hydroxy, carboxy, amino, C 1-3 alkylamino or di(C 1-3 alkyl)amino; or when m is 2, the two R 2 groups may be independently as defined above or may form together with adjacent ring carbon atoms the butadienylene group; R 3 is C 1-6 alkoxy-carbonyl, carboxamide, N-C 1-3 alkyl carboxamide or N,N-di-(C 1-3 alkyl)carboxamide.
Claim 2
Dependent Claim
99 words
A compound of the formula: ##STR6## wherein m is 1 or 2; R ' 1 is hydrogen, C 1-6 alkyl, phenyl, C 1-6 alkoxy-carbonyl, hydroxy, C 1-4 alkoxy, amino or C 1-3 alkylamino; each R 2 is independently C 1-6 alkyl, C 1-4 alkoxy, halogen, nitro, hydroxy, carboxy, amino, C 1-3 alkylamino or di(C 1-3 alkyl)amino; or when m is 2, the two R 2 groups may be independently as defined above or may form together with adjacent ring carbon atoms the butadienylene group; R 3 is C 1-6 alkoxy-carbonyl, carboxamide, N-C 1-3 alkyl carboxamide or N,N-di-(C 1-3 alkyl)carboxamide.
Claim 3
Dependent Claim
12 words
A compound of claim 1, wherein R 3 is C 1-6 alkoxycarbonyl.
Claim 4
Dependent Claim
10 words
A compound of claim 1, wherein R 3 is carboxamide.
Claim 5
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 7-ethyl-2-methyl-1-azaxanthone-3-carboxylate.
Claim 6
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 7-methoxy-2-methyl-1-azaxanthone-3-carboxylate.
Claim 7
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 7,9-dimethyl-2-methyl-1-azaxanthone-3-carboxylate.
Claim 8
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 7-chloro-2-methol-1-azaxanthone-3-carboxylate.
Claim 9
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 7-nitro-2-methyl-1-azaxanthone-3-carboxylate.
Claim 10
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 2-amino-7-ethyl-1-azaxanthone-3-carboxylate.
Claim 11
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 2-amino-7-methoxy-1-azaxanthone-3-carboxylate.
Claim 12
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 2-amino-7,9-dimethyl-1-azaxanthone-3-carboxylate.
Claim 13
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 2-amino-7-chloro-1-azaxanthone-3-carboxylate.
Claim 14
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 2-amino-7-methyl-1-azaxanthone-3-carboxylate.
Claim 15
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 2-amino-7-isopropyl-1-azaxanthone-3-carboxylate.
Claim 16
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 2-amino-7-n-butyl-1-azaxanthone-3-carboxylate.
Claim 17
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 2-amino-7-methoxy-1-azaxanthone-3-carboxylate.
Claim 18
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 2-amino-9-methoxy-1-azaxanthone-3-carboxylate.
Claim 19
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 2-amino-8-hydroxy-1-azaxanthone-3-carboxylate.
Claim 20
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 2-amino-benzo[h]-1-azaxanthone-3-carboxylate.
Claim 21
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 7-ethyl-2-phenyl-1-azaxanthone-3-carboxylate.
Claim 22
Dependent Claim
10 words
A compound of claim 1, wherein the compound is 2-amino-7-ethyl-1-azaxanthone-3-carboxamide.
Claim 23
Dependent Claim
10 words
A compound of claim 1, wherein the compound is 2-amino-7-chloro-1-azaxanthone-3-carboxamide.
Claim 24
Dependent Claim
12 words
A compound of claim 1, wherein the compound is dimethyl 7-ethyl-1-azaxanthone-2, 3-dicarboxylate.
Claim 25
Dependent Claim
11 words
A compound of claim 1, wherein the compound is diethyl 7-ethyl-1-azaxanthone-2,3-dicarboxylate.
Claim 26
Dependent Claim
11 words
A compound of claim 1, wherein the compound is diethyl, 7,9-dimethyl-1-azaxanthone-2,3-dicarboxylate.
Claim 27
Dependent Claim
11 words
A compound of claim 1, wherein the compound is dimethyl 7-chloro-1-azaxanthone-2,3-dicarboxylate.
Claim 28
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 7-chloro-1-azaxanthone-3-carboxylate.
Claim 29
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 7-nitro-1-azaxanthone-3-carboxylate.
Claim 30
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 7-methyl-2-hydroxy-1-azaxanthone-3-carboxylate.
Claim 31
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 7-ethyl-2-hydroxy-1-azaxanthone-3-carboxylate.
Claim 32
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 7-n-butyl-2-hydroxy-1-azaxanthone-3-carboxylate.
Claim 33
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 7-methoxy-2-hydroxy-1-azaxanthone-3-carboxylate.
Claim 34
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 9-methoxy-2-hydroxy-1-azaxanthone-3-carboxylate.
Claim 35
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 2-hydroxy-7,9-dimethyl-1-azaxanthone-3-carboxylate.
Claim 36
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 7-ethyl-2-methoxy-1-azaxanthone-3-carboxylate.
Claim 37
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl 7-ethyl-2-methylamino-1-azaxanthone-3-carboxylate.
Claim 38
Dependent Claim
12 words
A compound of claim 1, wherein the compound is ethyl 7-ethyl-1- azaxanthone-3-carboxylate.
Claim 39
Dependent Claim
11 words
A compound of claim 1, wherein the compound is ethyl benzo[h]-1-azaxanthone-3-carboxylate.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-11-09 | 1985-05-11 | 1985-11-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-11-09 | 1989-05-11 | 1989-11-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-11-09 | 1993-05-11 | 1993-11-10 | $7700.00 | Window Closed / Lapsed |