US4299953A
Expired / Lapsed
US
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Mycarosyltylactone
Assignee: Eli Lilly and Co
•
Filing: 1980-07-29
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Granted: 1981-11-10
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Expires: 2000-07-29
Abstract
Abstract Mycarosyltylactone (5-O-mycarosyl-20-dihydro-20,23-dideoxytylonolide) which has the formula: <IMAGE> 3,4'-diacyl ester derivatives of mycarosyltylactone wherein each of said esters is an ester of a monocarboxylic acid or a hemi-ester of a dicarboxylic acid, each of 1 to 18 carbon atoms, and the corresponding 3-acyl ester derivatives of tylactone, are useful intermediates in the preparation of macrolide antibiotics. New methods for making tylactone and the 3-acyl ester derivatives of tylactone are provided.
Inventors
- 👤 Robert L. Hamill
- 👤 Gene M. Wild
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 13:41
CPC Classifications
C; C07; C07H; C07H17/00; C07H17/04; C07H17/08; A; A61; A61P; A61P31/00; A61P31/04; C07D; C07D313/00; C12; C12N; C12N1/00; C12N1/20; C12N1/205; C12P; C12P17/00; C12P17/02; C12P17/08; C12P19/00; C12P19/44; C12P19/60; C12P19/62; C12R; C12R2001/00; C12R2001/01; C12R2001/465; C12R2001/54
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
39 words
Mycarosyltylactone which has the structure: ##STR6## and the 3,4'-diacyl ester derivatives of mycarosyltylactone wherein each of said esters is an ester of a monocarboxylic acid or a hemi-ester of a dicarboxylic acid, each of 1 to 18 carbon atoms.
Claim 2
Dependent Claim
39 words
Mycarosyltylactone which has the structure: ##STR6## and the 3,4'-diacyl ester derivatives of mycarosyltylactone wherein each of said esters is an ester of a monocarboxylic acid or a hemi-ester of a dicarboxylic acid, each of 1 to 18 carbon atoms.
Claim 3
Dependent Claim
8 words
The compound of claim 1 which is mycarosyltylactone.
Claim 4
Dependent Claim
13 words
The compounds of claim 1 which are the 3,4'-diacyl ester derivatives of mycarosyltylactone.
Claim 5
Dependent Claim
8 words
The compound of claim 3 which is 3,4'-di-O-acetyl-5-O-mycarosyltylactone.
Claim 6
Dependent Claim
8 words
The compound of claim 3 which is 3,4'-di-O-propionyl-5-O-mycarosyltylactone.
Claim 7
Dependent Claim
8 words
The compound of claim 3 which is 3,4'-di-O-benzoyl-5-O-mycarosyltylactone.
Claim 8
Dependent Claim
8 words
The compound of claim 3 which is 3,4'-di-O-isovaleryl-5-O-mycarosyltylactone.
Claim 9
Dependent Claim
8 words
The compound of claim 3 which is 3,4'-di-O-(n-butyryl)mycarosyltylactone.
Claim 10
Dependent Claim
28 words
3-O-acyltylactone compounds which have the formula: ##STR7## wherein R is an acyl moiety derived from a monocarboxylic acid or dicarboxylic acid of from 1 to 18 carbon atoms.
Claim 11
Dependent Claim
28 words
3-O-acyltylactone compounds which have the formula: ##STR7## wherein R is an acyl moiety derived from a monocarboxylic acid or dicarboxylic acid of from 1 to 18 carbon atoms.
Claim 12
Dependent Claim
8 words
The compound of claim 9 which is 3-O-acetyltylactone.
Claim 13
Dependent Claim
8 words
The compound of claim 9 which is 3-O-propionyltylactone.
Claim 14
Dependent Claim
8 words
The compound of claim 9 which is 3-O-isovaleryltylactone.
Claim 15
Dependent Claim
8 words
The compound of claim 9 which is 3-O-benzoyltylactone.
Claim 16
Dependent Claim
8 words
The compound of claim 9 which is 3-(n-butyryl)tylactone.
References Cited (Backward Citations)
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US4161523A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-11-09 | 1985-05-11 | 1985-11-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-11-09 | 1989-05-11 | 1989-11-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-11-09 | 1993-05-11 | 1993-11-10 | $7700.00 | Window Closed / Lapsed |