US4298609A
Expired / Lapsed
US
⏱️ 0.0 years remaining
4,5-Dihydro-6-(4-pyridinyl)-3-pyridazinol and salts, their preparation and use as blood pressure lowering agents
Assignee: Sanofi SA
•
Filing: 1979-08-30
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Granted: 1981-11-03
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Expires: 1999-08-30
Abstract
Abstract 4,5-Dihydro-6-(4-pyridinyl)-3-pyridazinol or pharmaceutically-acceptable acid-addition salt thereof is useful as a blood pressure lowering agent. 4,5-Dihydro-6-(4-pyridinyl)-3-pyridazinol is prepared by reacting γ-oxo-γ-(4-pyridinyl)butyronitrile with a hydrazine salt of a strong inorganic or organic sulfonic acid. Said 4,5-dihydro-6-(4-pyridinyl)-3-pyridazinol or pharmaceutically-acceptable salt thereof is shown as the active ingredient in pharmaceutical compositions for lowering blood pressure and in the method for lowering blood pressure in a patient having elevated blood pressure.
Inventors
- 👤 George Y. Lesher
- 👤 William B. Dickinson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 23:56
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61K31/50
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
42 words
The method for lowering blood pressure in a patient having elevated blood pressure which comprises administering orally or parenterally in a solid or liquid dosage form to such patient a blood pressure lowering effective amount of 4,5-dihydro-6-(4-pyridinyl)-3-pyridazinol or pharmaceutically-acceptable acid-addition salt thereof.
Claim 2
Independent Claim
42 words
The method for lowering blood pressure in a patient having elevated blood pressure which comprises administering orally or parenterally in a solid or liquid dosage form to such patient a blood pressure lowering effective amount of 4,5-dihydro-6-(4-pyridinyl)-3-pyridazinol or pharmaceutically-acceptable acid-addition salt thereof.
Claim 3
Dependent Claim
6 words
4,5-Dihydro-6-(4-pyridinyl)-3-pyridazinol or pharmaceutically-acceptable acid-addition salt thereof.
Claim 4
Dependent Claim
6 words
4,5-Dihydro-6-(4-pyridinyl)-3-pyridazinol or pharmaceutically-acceptable acid-addition salt thereof.
Claim 5
Dependent Claim
1 words
4,5-Dihydro-6-(4-pyridinyl)-3-pyridazinol.
Claim 6
Dependent Claim
1 words
4,5-Dihydro-6-(4-pyridinyl)-3-pyridazinol.
Claim 7
Dependent Claim
32 words
A pharmaceutical composition for lowering blood pressure, which comprises a pharmaceutically-acceptable inert carrier and, as the active component thereof, a blood pressure lowering effective amount of 4,5-dihydro-6-(4-pyridinyl)-3-pyridazinol or pharmaceutically-acceptable acid-addition salt thereof.
Claim 8
Dependent Claim
32 words
A pharmaceutical composition for lowering blood pressure, which comprises a pharmaceutically-acceptable inert carrier and, as the active component thereof, a blood pressure lowering effective amount of 4,5-dihydro-6-(4-pyridinyl)-3-pyridazinol or pharmaceutically-acceptable acid-addition salt thereof.
Claim 9
Dependent Claim
12 words
A composition according to claim 4 where the active component is 4,5-dihydro-6-(4-pyridinyl)-3-pyridazinol.
Claim 10
Dependent Claim
25 words
The process which comprises heating at about 65°-120° C. γ-oxo-γ-(4-pyridinyl)butyronitrile with a hydrazine salt of a strong inorganic or organic sulfonic acid to produce 4,5-dihydro-6-(4-pyridinyl)-3-pyridazinol.
Claim 11
Dependent Claim
25 words
The process which comprises heating at about 65°-120° C. γ-oxo-γ-(4-pyridinyl)butyronitrile with a hydrazine salt of a strong inorganic or organic sulfonic acid to produce 4,5-dihydro-6-(4-pyridinyl)-3-pyridazinol.
Claim 12
Dependent Claim
20 words
The process according to claim 6 where the reaction is run by refluxing γ-oxo-γ-(4-pyridinyl)butyronitrile with hydrazine sulfate in aqueous ethanol.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-11-02 | 1985-05-04 | 1985-11-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-11-02 | 1989-05-04 | 1989-11-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-11-02 | 1993-05-04 | 1993-11-03 | $7700.00 | Window Closed / Lapsed |