US4298593A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Reagents and methods utilizing labeled Fab bound to antigens
Assignee: Abbott Laboratories
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Filing: 1979-08-21
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Granted: 1981-11-03
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Expires: 1999-08-21
Abstract
Abstract This invention involves an improvement in a method for immunochemically assaying a member of an antigen-antibody binding pair in serum or plasma which utilizes labeled antigen having a plurality of antigenic binding sites as the indicating reagent, the improvement comprising employing the antigen immunochemically bound to labeled Fab as the indicating reagent. This invention also encompasses reagents useful in practicing the above method. These methods and reagents are particularly useful in hepatitis detection.
Inventors
- 👤 Chung-Mei Ling
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 15:40
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/563; Y; Y10; Y10S; Y10S435/00; Y10S435/961; Y10S435/964; Y10S436/00; Y10S436/804; Y10S436/807; Y10S436/808; Y10S436/82; Y10S530/00; Y10S530/806; Y10S530/827; Y10S530/829; Y10S530/863; Y10S530/866
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
40 words
An immunoassay reagent comprising a solution of an antigen having a plurality of antigenic binding sites wherein a portion of the binding sites are immunochemically bound to labeled Fab and other immunochemically binding sites are available for binding to antibodies.
Claim 2
Dependent Claim
40 words
An immunoassay reagent comprising a solution of an antigen having a plurality of antigenic binding sites wherein a portion of the binding sites are immunochemically bound to labeled Fab and other immunochemically binding sites are available for binding to antibodies.
Claim 3
Dependent Claim
17 words
An immunoassay reagent, according to claim 1, which is hepatitis core antigen immunochemically bound to labeled Fab.
Claim 4
Dependent Claim
18 words
An immunoassay reagent, according to claim 1, which is hepatitis A viral antigen immunochemically bound to labeled Fab.
Claim 5
Independent Claim
49 words
A method for preparing an immunoassay reagent comprising immunochemically reacting labeled Fab with an antigen in solution wherein the antigen has a plurality of antigenic binding sites and wherein a portion of said antigenic binding sites remain available for immunochemically binding to antibody after reaction with the labeled Fab.
Claim 6
Independent Claim
49 words
A method for preparing an immunoassay reagent comprising immunochemically reacting labeled Fab with an antigen in solution wherein the antigen has a plurality of antigenic binding sites and wherein a portion of said antigenic binding sites remain available for immunochemically binding to antibody after reaction with the labeled Fab.
References Cited (Backward Citations)
US4193982A
Cited
US4166106A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-11-02 | 1985-05-04 | 1985-11-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-11-02 | 1989-05-04 | 1989-11-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-11-02 | 1993-05-04 | 1993-11-03 | $7700.00 | Window Closed / Lapsed |