US4295968A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Separating materials for thin layer chromatography and their preparation
Assignee: Merck Patent GmbH
•
Filing: 1978-03-20
•
Granted: 1981-10-20
•
Expires: 1998-03-20
Abstract
Abstract A separating material for thin-layer chromatography, comprising a substrate material coated with a thin sorbent layer, wherein the sorbent layer optionally contains a binder, an indicator, or both, is improved in that the sorbent layer has a surface modified by reacting the sorbent layer with a silanizing agent without the exclusion of moisture.
Inventors
- 👤 Herbert Halpaap
- 👤 Karl-Friedrich Krebs
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 23:41
CPC Classifications
G; G01; G01N; G01N30/00; G01N30/90; G01N30/92; G01N30/93; B; B01; B01J; B01J20/00; B01J20/02; B01J20/10; B01J20/103; B01J20/28; B01J20/28014; B01J20/2803; B01J20/28054; B01J20/28057; B01J20/281; B01J20/286; B01J20/287; B01J20/30; B01J20/3042; B01J20/32; B01J20/3202; B01J20/3204; B01J20/3231; B01J20/3242; B01J20/3244; B01J20/3246; G01N30/02; G01N30/50; B01J2220/00; B01J2220/50; B01J2220/54
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
46 words
In a separating material for thin-layer chromatography, comprising a substrate material having a coating thereon which coating comprises a thin sorbent layer, the improvement wherein the sorbent layer has a surface modified by reacting the sorbent layer with a silanizing agent without the exclusion of moisture.
Claim 2
Dependent Claim
46 words
In a separating material for thin-layer chromatography, comprising a substrate material having a coating thereon which coating comprises a thin sorbent layer, the improvement wherein the sorbent layer has a surface modified by reacting the sorbent layer with a silanizing agent without the exclusion of moisture.
Claim 3
Dependent Claim
31 words
A separating material of claim 1, wherein the sorbent layer is modified by aryl, substituted aryl, aralkyl, substituted aralkyl, alkyl or substituted alkyl groups, each of up to 20 carbon atoms.
Claim 4
Dependent Claim
13 words
(Amended) A separating material of claim 1, wherein the sorbent is silica gel.
Claim 5
Dependent Claim
101 words
A process for the production of a separating material for thin layer chromatography, comprising a substrate material having a coating thereon, which coating comprises a thin sorbent layer having a surface modified by reacting the sorbent layer with a silanizing agent without the exclusion of moisture, said process comprising impregnating the sorbent layer of a conventional TLC separating material with an unmodified surface with a solution of the silanizing agent in an organic solvent; drying the impregnated layer in air; subsequently washing the dried layer with at least one aprotic solvent; and then washing it with at least one protonic solvent.
Claim 6
Dependent Claim
101 words
A process for the production of a separating material for thin layer chromatography, comprising a substrate material having a coating thereon, which coating comprises a thin sorbent layer having a surface modified by reacting the sorbent layer with a silanizing agent without the exclusion of moisture, said process comprising impregnating the sorbent layer of a conventional TLC separating material with an unmodified surface with a solution of the silanizing agent in an organic solvent; drying the impregnated layer in air; subsequently washing the dried layer with at least one aprotic solvent; and then washing it with at least one protonic solvent.
Claim 7
Dependent Claim
35 words
A process of claim 4, wherein the silanizing agent is a methyl-alkyl, methyl-aryl, or methyl-aralkyl dichlorosilane with aryl, substituted aryl, aralkyl, substituted aralkyl, alkyl or substituted alkyl groups, each of up to 20 carbon atoms.
Claim 8
Dependent Claim
12 words
The separating material prepared by the process of claim 4 or 5.
Claim 9
Dependent Claim
16 words
The separating material of claim 1, wherein the sorbent is aluminum oxide, silica gel or kieselguhr.
Claim 10
Dependent Claim
13 words
The separating material of claim 1, wherein the binder is an organic binder.
Claim 11
Dependent Claim
14 words
The separating material of claim 1, wherein the sorbent layer further comprises a binder.
Claim 12
Dependent Claim
14 words
The separating material of claim 1, wherein the sorbent layer further comprises an indicator.
Claim 13
Dependent Claim
36 words
A separating material of claim 1 wherein the silanizing agent is a methyl-alkyl, methyl-aryl, or methyl-aralkyl dichlorosilane with aryl, substituted aryl, aralkyl, substituted aralkyl, alkyl or substituted alkyl groups, each of up to 20 carbon atoms.
Claim 14
Dependent Claim
28 words
The separating material of claim 1, wherein the sorbent layer has a surface modified by reacting the sorbent layer with a silanizing agent in the presence of air.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-10-19 | 1985-04-20 | 1985-10-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-10-19 | 1989-04-20 | 1989-10-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-10-19 | 1993-04-20 | 1993-10-20 | $7700.00 | Window Closed / Lapsed |