US4294839A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Benzothiazole derivatives and pharmaceutical formulations containing them
Assignee: Merck Patent GmbH
•
Filing: 1980-12-12
•
Granted: 1981-10-13
•
Expires: 2000-12-12
Abstract
Abstract Benzothiazole derivatives of the formula I ##STR1## wherein R 1 is H or CH 3 ; R 2 is phenyl, tolyl, xylyl or pyridyl; R 3 is OH, alkoxy of 1-4 C atoms or -NHCH 2 CH 2 OH; and R 4 is H, Cl, Br, OH or alkoxy of 1-4 C atoms, and physiologically acceptable salts thereof, have valuable pharmacological properties.
Inventors
- 👤 Thomas Doll
- 👤 Erich Schacht
- 👤 Hans-Eckart Radunz
- 👤 Ernst Schulze
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 09:34
CPC Classifications
C; C07; C07D; C07D277/00; C07D277/60; C07D277/62; C07D277/68; C07D277/70; C07D277/74; A; A61; A61P; A61P3/00; A61P3/06; A61P9/00; A61P9/10
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
59 words
A benzothiazole derivative of the formula ##STR4## wherein R 1 is H or CH 3 ; R 2 is phenyl, tolyl, xylyl or pyridyl; R 3 is OH, alkoxy of 1-4 C atoms or --NHCH 2 CH 2 OH; and R 4 is H, Cl, Br, OH or alkoxy of 1-4 C atoms, or a physiologically acceptable salt thereof.
Claim 2
Dependent Claim
59 words
A benzothiazole derivative of the formula ##STR4## wherein R 1 is H or CH 3 ; R 2 is phenyl, tolyl, xylyl or pyridyl; R 3 is OH, alkoxy of 1-4 C atoms or --NHCH 2 CH 2 OH; and R 4 is H, Cl, Br, OH or alkoxy of 1-4 C atoms, or a physiologically acceptable salt thereof.
Claim 3
Dependent Claim
12 words
A compound of claim 1 wherein R 1 is CH 3 .
Claim 4
Dependent Claim
14 words
A compound of claim 1 wherein R 2 is phenyl, p-tolyl, 2,3-dimethylphenyl or 2-pyridyl.
Claim 5
Dependent Claim
23 words
A compound of claim 1 wherein R 3 is OH, --OCH 3 , --OC 2 H 5 or --NHCH 2 CH 2 OH.
Claim 6
Dependent Claim
17 words
A compound of claim 1 wherein R 4 is H, Cl or --OC 2 H 5 .
Claim 7
Dependent Claim
11 words
2-(6-ethoxy-benzothiazol-2-yltio)-2-phenylpropionic acid, or 2-(6-ethoxy-benzothiazol-2-ylthio)-2-phenylpropionic acid ethyl ester, compounds of claim 1.
Claim 8
Dependent Claim
26 words
A pharmaceutical composition comprising an amount of a compound of claim 1 effective to lower the lipid level in a patient, and a pharmaceuutically acceptable carrier.
Claim 9
Dependent Claim
32 words
A method of lowering the lipid level in a patient in need of such lowering, comprising administering to the patient an amount of a compound of claim 1 effective for such lowering.
References Cited (Backward Citations)
US2647877A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-10-12 | 1985-04-13 | 1985-10-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-10-12 | 1989-04-13 | 1989-10-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-10-12 | 1993-04-13 | 1993-10-13 | $7700.00 | Window Closed / Lapsed |