US4294825A
Expired / Lapsed
US
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Process for the production of an andrexogenic substance having specific effect on the central regulation of food intake
Assignee: Richter Gedeon Vegyeszeti Gyar RT
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Filing: 1979-08-23
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Granted: 1981-10-13
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Expires: 1999-08-23
Abstract
Abstract Described is the method of preparing satietin, a peptide separated from plasma or serum and possessing the effect of inhibiting food intake. Also described is the product satietin.
Inventors
- 👤 Jozsef Knoll
- 👤 Huba Kalasz
- 👤 Berta Knoll
- 👤 Janos Nagy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 19:02
CPC Classifications
A; A23; A23J; A23J1/00; A23J1/06; A61; A61P; A61P3/00; A61P3/04; C; C07; C07K; C07K14/00; C07K14/435; C07K14/46; C07K14/47; C07K14/4701; C07K14/4702; A61K; A61K38/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
164 words
A process for the preparation of an endogenous anorexogenic substance having a satiety effect on the central regulation of food intake which comprises the steps of: (a) membrane filtering mammalian serum or plasma to separate out materials having a molecular weight of up to 50,000 as a filtrate; (b) drying the filtrate; (c) dissolving the filtrate dried during step (b) in water; (d) chromatografically fractioning on a gel with a void volume under 50,000 the filtrate dissolved during step (c) with a `neutral`, aqueous, eluting salt solution containing at least 0.1% of the salt to obtain a fraction with high anorexogenic activity; (e) drying the fraction with high anorexogenic activity; (f) dissolving the fraction with high anorexogenic activity in water; (g) subjecting the fraction with high anorexogenic activity to a second chromatographic fractioning on a gel with a void volume under 50,000 with distilled water to obtain a second fraction of higher anorexogenic activity; and (h) lyophilizing the second fraction of higher anorexogenic activity.
Claim 2
Dependent Claim
164 words
A process for the preparation of an endogenous anorexogenic substance having a satiety effect on the central regulation of food intake which comprises the steps of: (a) membrane filtering mammalian serum or plasma to separate out materials having a molecular weight of up to 50,000 as a filtrate; (b) drying the filtrate; (c) dissolving the filtrate dried during step (b) in water; (d) chromatografically fractioning on a gel with a void volume under 50,000 the filtrate dissolved during step (c) with a `neutral`, aqueous, eluting salt solution containing at least 0.1% of the salt to obtain a fraction with high anorexogenic activity; (e) drying the fraction with high anorexogenic activity; (f) dissolving the fraction with high anorexogenic activity in water; (g) subjecting the fraction with high anorexogenic activity to a second chromatographic fractioning on a gel with a void volume under 50,000 with distilled water to obtain a second fraction of higher anorexogenic activity; and (h) lyophilizing the second fraction of higher anorexogenic activity.
Claim 3
Dependent Claim
14 words
The process defined in claim 1, step (d), wherein the salt is sodium chloride.
Claim 4
Dependent Claim
25 words
The process defined in claim 1 wherein following step (g) the second fraction of higher anorexogenic activity is subjected to a third gel chromatographic fractioning.
Claim 5
Dependent Claim
10 words
The product produced according to the process of claim 1.
Claim 6
Dependent Claim
29 words
An anorexogenic method of treatment which comprises the step of administering to a mammal an anorexogenically effective amount of the product obtained according to the process of claim 1.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-10-12 | 1985-04-13 | 1985-10-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-10-12 | 1989-04-13 | 1989-10-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-10-12 | 1993-04-13 | 1993-10-13 | $7700.00 | Window Closed / Lapsed |