Patent US1567725A successfully refreshed from Google Patents.
US4292972A
Expired / Lapsed
US
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Lyophilized hydrocolloio foam
Assignee: ER Squibb and Sons LLC
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Filing: 1980-07-09
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Granted: 1981-10-06
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Expires: 2000-07-09
Abstract
Abstract A lyophilized foam sponge product having medically useful hemostatic and adhesive properties formed from the hydrocolloids, gelatin, pectin, and sodium carboxymethylcellulose and having a density of from about 0.01 to about 0.10 grams/cc. The gelatin is present at from about 20% to about 80% by weight of the final product and the pectin and sodium carboxymethylcellulose are each present at from about 10% to about 50% by weight of the final product. The product is prepared by forming an aqueous colloidal dispersion of hydrocolloids, aerating or foaming, freezing, and lyophilizing.
Inventors
- 👤 John M. Pawelchak
- 👤 Yu-chang J. Wang
- 👤 Anthony L. LaVia
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:02
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/001; A61L24/0036; A61L15/00; A61L15/16; A61L15/42; A61L15/60; A61L24/04; A61L24/043; A61L2400/00; A61L2400/04
Claims Analysis
Total Claims: 32
Claim 1
Independent Claim
69 words
A medically useful lyophilized sponge product having a density of from about 0.01 to about 0.10 gm/cc, said sponge product comprising a mixture of the hydrocolloids, gelatin, pectin, and sodium carboxymethylcellulose, said pectin and sodium carboxymethylcellulose each being at from about 10% to about 50% by weight of the final product and said gelatin being present at from about 20% to about 80% by weight of the final product.
Claim 2
Dependent Claim
69 words
A medically useful lyophilized sponge product having a density of from about 0.01 to about 0.10 gm/cc, said sponge product comprising a mixture of the hydrocolloids, gelatin, pectin, and sodium carboxymethylcellulose, said pectin and sodium carboxymethylcellulose each being at from about 10% to about 50% by weight of the final product and said gelatin being present at from about 20% to about 80% by weight of the final product.
Claim 3
Dependent Claim
45 words
The product of claim 1 wherein said pectin and sodium carboxymethylcellulose are each present at from about 15% to about 35% by weight of the final product and said gelatin is present at from about 30% to about 70% by weight of the final product.
Claim 4
Dependent Claim
21 words
The product of claim 2 wherein said gelatin, pectin, and sodium carboxymethylcellulose are present in about the same amount by weight.
Claim 5
Dependent Claim
12 words
The product of claim 3 having a density of about 0.04 gm/cc.
Claim 6
Dependent Claim
29 words
The product of claim 2 wherein said gelatin is present at about 50% by weight and said pectin and sodium carboxymethylcellulose are each present at about 25% by weight.
Claim 7
Dependent Claim
12 words
The product of claim 5 having a density of about 0.02 gm/cc.
Claim 8
Dependent Claim
12 words
The product of claim 5 having a density of about 0.03 gm/cc.
Claim 9
Dependent Claim
29 words
The product of claim 2 wherein said gelatin is present at about 60% by weight and said pectin and sodium carboxymethylcellulose are each present at about 20% by weight.
Claim 10
Dependent Claim
12 words
The product of claim 8 having a density of about 0.03 gm/cc.
Claim 11
Dependent Claim
14 words
The product of claim 1 wherein one or more of said hydrocolloids is cross-linked.
Claim 12
Dependent Claim
15 words
The product of claim 1 wherein a pharmaceutically active material is included within the sponge.
Claim 13
Dependent Claim
12 words
The product of claim 11 wherein the pharmaceutically active material is thrombin.
Claim 14
Dependent Claim
15 words
The product of claim 1 having enhanced flexibility resulting from the inclusion of a plasticizer.
Claim 15
Dependent Claim
28 words
The process of providing hemostatis at the site of a wound which comprises contacting the wound with an effective amount of the foam sponge product of claim 1.
Claim 16
Dependent Claim
25 words
The process of adhering bodily tissue which comprises pressing an effective amount of the foam sponge product of claim 1 between the sections of tissue.
Claim 17
Dependent Claim
126 words
A process for preparing a medically useful sponge product comprising (a) forming a dry blend comprising a mixture of the hydrocolloids, gelatin, pectin, and sodium carboxymethylcellulose said pectin and sodium carboxymethyl cellulose each being present at from about 10% to about 50% by weight of product and said gelatin being present at from about 20% to about 80% by weight of the product; (b) adding said dry blend to water with agitation to form a colloidal dispersion said dispersion having a solids content of from about 1% to about 20% by weight; (c) aerating or foaming the colloidal dispersion so that its volume increases by about 10% to about 600%; (d) pouring said aerating or foaming dispersion into a suitable receptacle; (e) freezing; and (f) lyophilizing.
Claim 18
Dependent Claim
126 words
A process for preparing a medically useful sponge product comprising (a) forming a dry blend comprising a mixture of the hydrocolloids, gelatin, pectin, and sodium carboxymethylcellulose said pectin and sodium carboxymethyl cellulose each being present at from about 10% to about 50% by weight of product and said gelatin being present at from about 20% to about 80% by weight of the product; (b) adding said dry blend to water with agitation to form a colloidal dispersion said dispersion having a solids content of from about 1% to about 20% by weight; (c) aerating or foaming the colloidal dispersion so that its volume increases by about 10% to about 600%; (d) pouring said aerating or foaming dispersion into a suitable receptacle; (e) freezing; and (f) lyophilizing.
Claim 19
Dependent Claim
68 words
The process of claim 16 wherein said pectin and sodium carboxymethylcellulose are each present at from about 15% to about 35% by weight of the final product and said gelatin is present at from about 30% to about 70% by weight of the final product; and wherein said colloidal dispersion contains from about 3% to about 9% by weight of the blend of pectin, gelatin, and sodium carboxymethylcellulose.
Claim 20
Dependent Claim
25 words
The process of claim 17 wherein said gelatin, pectin, and sodium carboxymethylcellulose are present in the dry blend in about the same amount by weight.
Claim 21
Dependent Claim
44 words
The process of claim 18 wherein said dispersion contains about 3% by weight of said dry blend and said foaming step is performed by blowing a stream of air to the bottom of said dispersion so as to expand its volume by about 30%.
Claim 22
Dependent Claim
33 words
The process of claim 17 wherein said gelatin is present at about 50% by weight and said pectin and sodium carboxymethylcellulose are each present at about 25% by weight in the dry blend.
Claim 23
Dependent Claim
32 words
The process of claim 20 wherein said colloidal dispersion contains about 6% by weight of said dry blend and wherein the aeration of the colloidal dispersion increases its volume by about 65%.
Claim 24
Dependent Claim
32 words
The process of claim 20 wherein said colloidal dispersion contains about 9% by weight of said dry blend and wherein the aeration of the colloidal dispersion increases its volume by about 65%.
Claim 25
Dependent Claim
32 words
The process of claim 17 wherein said gelatin is present at about 60% by weight and said pectin and sodium carboxymethylcellulose are each present at 20% by weight in the dry blend.
Claim 26
Dependent Claim
31 words
The process of claim 23 wherein said colloidal dispersion contains about 9% by weight of said dry blend and wherein the aeration of the colloidal dispersion increases its volume about 65%.
Claim 27
Dependent Claim
34 words
The process of claim 16 wherein a cross-linking agent is added to the colloidal dispersion at from about 0.1% to about 10% by weight based upon the weight of dry blend in the dispersion.
Claim 28
Dependent Claim
16 words
The process of claim 16 wherein the lyophilized product is exposed to a vaporized cross-linking agent.
Claim 29
Dependent Claim
16 words
The process of claim 16 wherein a pharmaceutically active material is added to the colloidal dispersion.
Claim 30
Dependent Claim
12 words
The process of claim 27 wherein the pharmaceutically active material is thrombin.
Claim 31
Dependent Claim
31 words
The process of claim 16 wherein a plasticizing agent is added to the colloidal dispersion at up to about 30% by weight based upon the weight dry blend in the solution.
Claim 32
Dependent Claim
23 words
The process of claim 16 wherein a surfactant is added to the colloidal dispersion to stabilize and enhance the quality of the foam.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-10-05 | 1985-04-06 | 1985-10-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-10-05 | 1989-04-06 | 1989-10-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-10-05 | 1993-04-06 | 1993-10-06 | $7700.00 | Window Closed / Lapsed |